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ORIGINAL CONTRIBUTION Intravenous Drug Administration During Out-of-Hospital Cardiac Arrest A Randomized Trial Theresa M. Olasveengen, MD Context Intravenous access and drug administration are included in advanced car- Kjetil Sunde, MD, PhD diac life support (ACLS) guidelines despite a lack of evidence for improved outcomes. Epinephrine was an independent predictor of poor outcome in a large epidemiologi- Cathrine Brunborg, MSc cal study, possibly due to toxicity of the drug or cardiopulmonary resuscitation (CPR) Jon Thowsen interruptions secondary to establishing an intravenous line and drug administration. Petter A. Steen, MD, PhD Objective To determine whether removing intravenous drug administration from an ACLS protocol would improve survival to hospital discharge after out-of-hospital Lars Wik, MD, PhD cardiac arrest. Design, Setting, and Patients Prospective, randomized controlled trial of consecu- NTRAVENOUS ACCESS AND DRUG AD- tive adult patients with out-of-hospital nontraumatic cardiac arrest treated within the emer- ministration are integral parts of gency medical service system in Oslo, Norway, between May 1, 2003, and April 28, 2008. cardiopulmonary resuscitation Interventions Advanced cardiac life support with intravenous drug administration I(CPR) guidelines. Millions of pa- or ACLS without access to intravenous drug administration. tients have received epinephrine dur- ing advanced cardiac life support Main Outcome Measures
JAMA – American Medical Association
Published: Nov 25, 2009
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