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Rethinking Screening for Breast Cancer and Prostate Cancer

Rethinking Screening for Breast Cancer and Prostate Cancer SPECIAL COMMUNICATION CLINICIAN’S CORNER Rethinking Screening for Breast Cancer and Prostate Cancer Laura Esserman, MD, MBA After 20 years of screening for breast and prostate cancer, several observa- Yiwey Shieh, AB tions can be made. First, the incidence of these cancers increased after Ian Thompson, MD the introduction of screening but has never returned to prescreening levels. REAST CANCER AND PROSTATE Second, the increase in the relative fraction of early stage cancers has in- cancer account for 26% of all creased. Third, the incidence of regional cancers has not decreased at a com- cancers in the United States, mensurate rate. One possible explanation is that screening may be increas- Bwith an estimated 386 560 pa- ing the burden of low-risk cancers without significantly reducing the burden tients diagnosed annually: 194 280 for of more aggressively growing cancers and therefore not resulting in the an- breast cancer and 192 280 for prostate ticipated reduction in cancer mortality. To reduce morbidity and mortality cancer For both, there are remarkable differences between outcomes of local- from prostate cancer and breast cancer, new approaches for screening, early ized vs advanced disease (breast can- detection, and prevention for both diseases should be considered. cer: http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Rethinking Screening for Breast Cancer and Prostate Cancer

JAMA , Volume 302 (15) – Oct 21, 2009

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References (93)

Publisher
American Medical Association
Copyright
Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2009.1498
pmid
19843904
Publisher site
See Article on Publisher Site

Abstract

SPECIAL COMMUNICATION CLINICIAN’S CORNER Rethinking Screening for Breast Cancer and Prostate Cancer Laura Esserman, MD, MBA After 20 years of screening for breast and prostate cancer, several observa- Yiwey Shieh, AB tions can be made. First, the incidence of these cancers increased after Ian Thompson, MD the introduction of screening but has never returned to prescreening levels. REAST CANCER AND PROSTATE Second, the increase in the relative fraction of early stage cancers has in- cancer account for 26% of all creased. Third, the incidence of regional cancers has not decreased at a com- cancers in the United States, mensurate rate. One possible explanation is that screening may be increas- Bwith an estimated 386 560 pa- ing the burden of low-risk cancers without significantly reducing the burden tients diagnosed annually: 194 280 for of more aggressively growing cancers and therefore not resulting in the an- breast cancer and 192 280 for prostate ticipated reduction in cancer mortality. To reduce morbidity and mortality cancer For both, there are remarkable differences between outcomes of local- from prostate cancer and breast cancer, new approaches for screening, early ized vs advanced disease (breast can- detection, and prevention for both diseases should be considered. cer:

Journal

JAMAAmerican Medical Association

Published: Oct 21, 2009

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