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Treatment of Fibromyalgia Syndrome With Antidepressants

Treatment of Fibromyalgia Syndrome With Antidepressants CLINICIAN’S CORNER CLINICAL REVIEW Treatment of Fibromyalgia Syndrome With Antidepressants A Meta-analysis Winfried Häuser, MD Context Fibromyalgia syndrome (FMS) is a chronic pain disorder associated with mul- Kathrin Bernardy, PhD tiple debilitating symptoms and high disease-related costs. Effective treatment op- tions are needed. Nurcan Üc¸eyler, MD Objectives To determine the efficacy of antidepressants in the treatment of FMS Claudia Sommer, MD by performing a meta-analysis of randomized controlled clinical trials. IBROMYALGIA SYNDROME (FMS) Data Sources MEDLINE, PsycINFO, Scopus, and the Cochrane Library databases has an estimated prevalence in were searched through August 2008. Reference sections of original studies, meta- North America and Europe of analyses, and reviews on antidepressants in FMS were reviewed. F0.5% to 5.8%. According to the Study Selection Randomized placebo-controlled trials with tricyclic and tetracyclic criteria of the American College of antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin and Rheumatology (ACR), FMS is defined noradrenaline reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (MAOIs) as chronic widespread pain and ten- were analyzed. derness at a minimum of 11 of 18 de- Data Extraction and Data Synthesis Two authors independently extracted data. fined tender points. Other symptoms Effects were summarized using standardized mean differences (SMDs) by a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Treatment of Fibromyalgia Syndrome With Antidepressants

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References (77)

Publisher
American Medical Association
Copyright
Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2008.944
pmid
19141768
Publisher site
See Article on Publisher Site

Abstract

CLINICIAN’S CORNER CLINICAL REVIEW Treatment of Fibromyalgia Syndrome With Antidepressants A Meta-analysis Winfried Häuser, MD Context Fibromyalgia syndrome (FMS) is a chronic pain disorder associated with mul- Kathrin Bernardy, PhD tiple debilitating symptoms and high disease-related costs. Effective treatment op- tions are needed. Nurcan Üc¸eyler, MD Objectives To determine the efficacy of antidepressants in the treatment of FMS Claudia Sommer, MD by performing a meta-analysis of randomized controlled clinical trials. IBROMYALGIA SYNDROME (FMS) Data Sources MEDLINE, PsycINFO, Scopus, and the Cochrane Library databases has an estimated prevalence in were searched through August 2008. Reference sections of original studies, meta- North America and Europe of analyses, and reviews on antidepressants in FMS were reviewed. F0.5% to 5.8%. According to the Study Selection Randomized placebo-controlled trials with tricyclic and tetracyclic criteria of the American College of antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin and Rheumatology (ACR), FMS is defined noradrenaline reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (MAOIs) as chronic widespread pain and ten- were analyzed. derness at a minimum of 11 of 18 de- Data Extraction and Data Synthesis Two authors independently extracted data. fined tender points. Other symptoms Effects were summarized using standardized mean differences (SMDs) by a

Journal

JAMAAmerican Medical Association

Published: Jan 14, 2009

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