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CLINICIAN’S CORNER CLINICAL REVIEW Treatment of Fibromyalgia Syndrome With Antidepressants A Meta-analysis Winfried Häuser, MD Context Fibromyalgia syndrome (FMS) is a chronic pain disorder associated with mul- Kathrin Bernardy, PhD tiple debilitating symptoms and high disease-related costs. Effective treatment op- tions are needed. Nurcan Üc¸eyler, MD Objectives To determine the efficacy of antidepressants in the treatment of FMS Claudia Sommer, MD by performing a meta-analysis of randomized controlled clinical trials. IBROMYALGIA SYNDROME (FMS) Data Sources MEDLINE, PsycINFO, Scopus, and the Cochrane Library databases has an estimated prevalence in were searched through August 2008. Reference sections of original studies, meta- North America and Europe of analyses, and reviews on antidepressants in FMS were reviewed. F0.5% to 5.8%. According to the Study Selection Randomized placebo-controlled trials with tricyclic and tetracyclic criteria of the American College of antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin and Rheumatology (ACR), FMS is defined noradrenaline reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (MAOIs) as chronic widespread pain and ten- were analyzed. derness at a minimum of 11 of 18 de- Data Extraction and Data Synthesis Two authors independently extracted data. fined tender points. Other symptoms Effects were summarized using standardized mean differences (SMDs) by a
JAMA – American Medical Association
Published: Jan 14, 2009
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