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PSA Thresholds for Prostate Cancer Detection

PSA Thresholds for Prostate Cancer Detection To the Editor. —I read with great interest the articles by Dr Catalona and colleagues1 and Dr Carter and colleagues2 regarding prostate-specific antigen (PSA) detection for prostate cancer. On one hand, Catalona et al found that the cancer detection rate was 22% when the screening PSA value was between 2.5 and 4.0 ng/mL and implied that vigilance was necessary in these men with lower PSA values. On the other hand, Carter et al found that considering as normal a PSA between 4.0 and 5.0 ng/mL maintains an acceptable ability to diagnose curable cancer and also suggested that men whose initial PSA level is less than 2.0 ng/mL may have screening every other year. Of great concern is that both studies lacked sufficient numbers of black men, who are known to have a higher prevalence of the disease and a propensity for more advanced cancer at diagnosis.3,4 With http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

PSA Thresholds for Prostate Cancer Detection

Moul, Judd W.
JAMA , Volume 278 (9) – Sep 3, 1997
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PSA Thresholds for Prostate Cancer Detection

Abstract



To the Editor.
—I read with great interest the articles by Dr Catalona and colleagues1 and Dr Carter and colleagues2 regarding prostate-specific antigen (PSA) detection for prostate cancer. On one hand, Catalona et al found that the cancer detection rate was 22% when the screening PSA value was between 2.5 and 4.0 ng/mL and implied that vigilance was necessary in these men with lower PSA values. On the other hand, Carter et al found that considering as...
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References (4)

Publisher
American Medical Association
Copyright
Copyright © 1997 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1997.03550090023013
Publisher site
See Article on Publisher Site

Abstract

To the Editor. —I read with great interest the articles by Dr Catalona and colleagues1 and Dr Carter and colleagues2 regarding prostate-specific antigen (PSA) detection for prostate cancer. On one hand, Catalona et al found that the cancer detection rate was 22% when the screening PSA value was between 2.5 and 4.0 ng/mL and implied that vigilance was necessary in these men with lower PSA values. On the other hand, Carter et al found that considering as normal a PSA between 4.0 and 5.0 ng/mL maintains an acceptable ability to diagnose curable cancer and also suggested that men whose initial PSA level is less than 2.0 ng/mL may have screening every other year. Of great concern is that both studies lacked sufficient numbers of black men, who are known to have a higher prevalence of the disease and a propensity for more advanced cancer at diagnosis.3,4 With

Journal

JAMA – American Medical Association

Published: Sep 3, 1997

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