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G. Guyatt, D. Sackett, D. Cook (1993)
Users' guides to the medical literature. II. How to use an article about therapy or prevention. A. Are the results of the study valid? Evidence-Based Medicine Working Group.JAMA, 270 21
R. Cook, D. Sackett (1995)
The number needed to treat: a clinically useful measure of treatment effectBMJ, 310
A. Detsky, D. Sackett (1985)
When was a "negative" clinical trial big enough? How many patients you needed depends on what you found.Archives of internal medicine, 145 4
Christopher Saudek, William Duckworth, Anita Giobbie-Hurder, W. Henderson, Robert Henry, David Kelley, Steven Edelman, Franklin Zieve, Robert Adler, James Anderson, Robert Anderson, Bruce Hamilton, Thomas Donner, M. Kirkman, M. Kirkman, Nancy Morgan (1996)
Implantable insulin pump vs multiple-dose insulin for non-insulin-dependent diabetes mellitus: a randomized clinical trial. Department of Veterans Affairs Implantable Insulin Pump Study Group.JAMA, 276 16
Diabetes Control, D. Nathan, S. Genuth, J. Lachin, P. Cleary, O. Crofford, M. Davis, L. Rand, C. Siebert (1993)
The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long‐Term Complications in Insulin‐Dependent Diabetes MellitusSurvey of Anesthesiology, 38
G. Guyatt, D. Sackett, D. Cook, G. Guyatt, E. Bass, P. Brill-Edwards, G. Browman, D. Cook, M. Farkouh, H. Gerstein, B. Haynes, R. Hayward, A. Holbrook, R. Jaeschke, E. Juniper, A. Laupacis, Hui Lee, M. Levine, V. Moyer, J. Nishikawa, A. Oxman, Ameen Patel, J. Philbrick, W. Richardson, Stephane Sauve, Jack Sinclair, K. Trout, P. Tugwell, S. Tunis, S. Walter, John Williams, Mark Wilson (1994)
Users' Guides to the Medical Literature: II. How to Use an Article About Therapy or Prevention B. What Were the Results and Will They Help Me in Caring for My Patients?JAMA, 271
To the Editor. —Dr Saudek and colleagues1 begin their article on intensive insulin therapy in individuals with NIDDM with the following sentence: "Intensified insulin therapy can be beneficial in preventing end-organ complications of diabetes, but imposes serious adverse effects of treatment" and conclude with "it is feasible to achieve very good glycemic control in NIDDM using either multiple-dose insulin or implantable insulin pump" therapy. These statements imply that it has been shown that strict glycemic control using frequent doses of insulin reduces the incidence of complications in NIDDM. However, that conclusion is based on results from the DCCT,2 which was performed exclusively in patients with IDDM.2 The suggestion that the results of the DCCT may be applicable to NIDDM patients is based on similarities in underlying mechanisms of complications occurring in patients with IDDM and those with NIDDM.3 Similar complications in different diseases may be treated using the same
JAMA – American Medical Association
Published: Feb 19, 1997
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