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Do Heavy Smokers Need a Higher Replacement Dose of Nicotine to Quit?

Do Heavy Smokers Need a Higher Replacement Dose of Nicotine to Quit? To the Editor. —In the context of previous research that supports the idea that heavy smokers are more likely to quit with higher levels of nicotine replacement,1 the trial by Dr Jorenby and colleagues,2 which concluded that "2 patches are no better than 1," was quite surprising. We believe that a careful inspection of the study actually supports the argument that heavy smokers do better with 2 nicotine patches than with 1. When viewed from the perspective of health care practitioners who typically use minimal behavioral counseling, the primary research question should be "With this heavy smoker who wants to quit, should I prescribe 1 or 2 nicotine patches?" If this was the primary research question, then the study by Jorenby et al was a positive study at 4 weeks comparing 44 mg/d to 22 mg/d in both heavy and light smokers (76% vs 49% for participants smoking http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Do Heavy Smokers Need a Higher Replacement Dose of Nicotine to Quit?

Westman, Eric C.; Rose, Jed E.
JAMA , Volume 275 (24) – Jun 26, 1996
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Do Heavy Smokers Need a Higher Replacement Dose of Nicotine to Quit?

Abstract



To the Editor.
—In the context of previous research that supports the idea that heavy smokers are more likely to quit with higher levels of nicotine replacement,1 the trial by Dr Jorenby and colleagues,2 which concluded that "2 patches are no better than 1," was quite surprising. We believe that a careful inspection of the study actually supports the argument that heavy smokers do better with 2 nicotine patches than with 1.
When viewed from the perspective of health care...
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References (5)

Publisher
American Medical Association
Copyright
Copyright © 1996 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1996.03530480024027
Publisher site
See Article on Publisher Site

Abstract

To the Editor. —In the context of previous research that supports the idea that heavy smokers are more likely to quit with higher levels of nicotine replacement,1 the trial by Dr Jorenby and colleagues,2 which concluded that "2 patches are no better than 1," was quite surprising. We believe that a careful inspection of the study actually supports the argument that heavy smokers do better with 2 nicotine patches than with 1. When viewed from the perspective of health care practitioners who typically use minimal behavioral counseling, the primary research question should be "With this heavy smoker who wants to quit, should I prescribe 1 or 2 nicotine patches?" If this was the primary research question, then the study by Jorenby et al was a positive study at 4 weeks comparing 44 mg/d to 22 mg/d in both heavy and light smokers (76% vs 49% for participants smoking

Journal

JAMA – American Medical Association

Published: Jun 26, 1996

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