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Alasdair Hunter (1984)
Neural tube defects in Eastern Ontario and Western Quebec: demography and family data.American journal of medical genetics, 19 1
D. Superneau, W. Wertelecki, J. Opitz, J. Reynolds (1985)
Similarity of effects--experimental hyperthermia as a teratogen and maternal febrile illness associated with oromandibular and limb defects.American journal of medical genetics, 21 3
N. Nilsen (1984)
Vascular abnormalities due to hyperthermia in chick embryos.Teratology, 30 2
F. Fraser, J. Skelton (1978)
POSSIBLE TERATOGENICITY OF MATERNAL FEVERThe Lancet, 312
P. Layde, L. Edmonds, J. Erickson (1980)
Maternal fever and neural tube defects.Teratology, 21 1
A. Milunsky, H. Jick, S. Jick, Carol Bruell, D. MacLaughlin, K. Rothman, W. Willett (1989)
Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects.JAMA, 262 20
W. Hunter, M. Ellert, L. Nequin, W. Suarez (1979)
Is hyperthermia a teratogen?British Medical Journal, 1
P. Chance, DavidW. Smith, W. James (1978)
HYPERTHERMIA AND MENINGOMYELOCELE AND ANENCEPHALYThe Lancet, 311
Helaine Pleet, John Graham, David Smith (1981)
Central nervous system and facial defects associated with maternal hyperthermia at four to 14 weeks' gestation.Pediatrics, 67 6
E. Sohar, Y. Shoenfeld, Y. Shapiro, A. Ohry, S. Cabili (1976)
Effects of exposure to Finnish sauna.Israel journal of medical sciences, 12 11
M. Uhari, A. Mustonen, K. Kouvalainen (1979)
Sauna habits of Finnish women during pregnancy.British Medical Journal, 1
K. Shiota (1982)
Neural tube defects and maternal hyperthermia in early pregnancy: epidemiology in a human embryo population.American journal of medical genetics, 12 3
M. Edwards (1972)
Influenza, hyperthermia, and congenital malformation.Lancet, 1 7745
J. Warkany (1986)
Teratogen update: hyperthermia.Teratology, 33 3
Edwards Mj (1967)
Congenital defects in guinea pigs. Following induced hyperthermia during gestation.Archives of pathology, 84
W. Webster, M. Edwards (1984)
Hyperthermia and the induction of neural tube defects in mice.Teratology, 29 3
K. Arora, B. Cohen, A. Beaudoin (1979)
Fetal and placental responses to artificially induced hyperthermia in rats.Teratology, 19 2
D. Cockroft, D. New (1978)
Abnormalities induced in cultured rat embryos by hyperthermia.Teratology, 17 3
J. Kleinebrecht, H. Michaelis, J. Michaelis, S. Koller (1979)
FEVER IN PREGNANCY AND CONGENITAL ANOMALIESThe Lancet, 313
A. Hendrickx, G. Stone, R. Henrickson, K. Matayoshi (1979)
Teratogenic effects of hyperthermia in the bonnet monkey (Macaca radiata).Teratology, 19 2
Nancy Fisher, David Smith (1981)
Occipital encephalocele and early gestational hyperthermia.Pediatrics, 68 4
P. Miller, DavidW. Smith, T. Shepard (1978)
MATERNAL HYPERTHERMIA AS A POSSIBLE CAUSE OF ANENCEPHALYThe Lancet, 311
C. Umpierre, W. Dukelow (1977)
Environmental heat stress effects in the hamster.Teratology, 16 2
O. Miettinen (1976)
Estimability and estimation in case-referent studies.American journal of epidemiology, 103 2
W. Hartley, G. Alexander, Marshall Edwards (1974)
Brain cavitation and micrencephaly in lambs exposed to prenatal hyperthermia.Teratology, 9 3
R. Wanner, M. Edwards, R. Wright (1976)
The effect of hyperthermia on the neuroepithelium of the 21‐day guinea‐pig foetus: Histologic and ultrastructural studyThe Journal of Pathology, 118
A. Lipson, John Optiz, J. Reynolds (1988)
Hirschsprung disease in the offspring of mothers exposed to hyperthermia during pregnancy.American journal of medical genetics, 29 1
L. Saxén, P. Holmberg, Markku Nurminen, E. Kuosma (1982)
Sauna and congenital defects.Teratology, 25 3
M. Edwards, R. Mulley, S. Ring, R. Wanner (1974)
Mitotic cell death and delay of mitotic activity in guinea-pig embryos following brief maternal hyperthermia.Journal of embryology and experimental morphology, 32 3
L. Kilham, V. Ferm (1976)
Exencephaly in fetal hamsters following exposure to hyperthermia.Teratology, 14 3
M. Harvey, M. McRorie, D. Smith (1981)
Suggested limits to the use of the hot tub and sauna by pregnant women.Canadian Medical Association journal, 125 1
J. German (1984)
Embryonic Stress Hypothesis of TeratogenesisThe Journal of Urology, 132
David Smith, S. Clarren, Mary Harvey (1978)
Hyperthermia as a Possible Teratogenic AgentObstetrical & Gynecological Survey, 34
M. Edwards (1986)
Hyperthermia as a teratogen: a review of experimental studies and their clinical significance.Teratogenesis, carcinogenesis, and mutagenesis, 6 6
Objective. —To determine if exposure to hot tub, sauna, fever, or electric blanket during early pregnancy was associated with an increased risk for neural tube defects (NTDs). Design. —Prospective follow-up study. Setting. —Mostly private obstetric practices, primarily in New England. Participants.—A cohort of 23491 women having serum alpha-fetoprotein screening or an amniocentesis were identified. Complete exposure and outcome information was available for 97% of these women. Outcome Measures. —Relative risks (RRs) were used to compare incidence of NTD in those exposed to heat with those who were not exposed to any heat. Crude RRs were calculated directly from the data. Unconfounded RRs were calculated using logistic regression. Results. —Women reporting any heat exposure (sauna, hot tub, fever, or electric blanket) in early pregnancy had a crude risk of their fetuses developing NTD of 1.6 (95% CI [confidence interval], 0.9 to 2.9). Women reporting exposure to sauna, hot tub, or fever in early pregnancy had a crude risk of their fetuses developing NTD 2.2 times that of women without heat exposure (95% CI, 1.2 to 4.1). For hot tub use, the crude RR was 2.9 (95% CI, 1.4 to 6.3); for sauna, 2.6 (95% CI, 0.7 to 10.1); for fever, 1.9 (95% CI, 0.8 to 4.1); and for electric blanket, 1.2 (95% CI, 0.5 to 2.6). Multivariate adjusted RRs for individual heat sources, after controlling for maternal age, folic acid supplements, family history of NTD, and exposure to other heat sources, were for hot tub use, 2.8 (95% CI, 1.2 to 6.5); sauna, 1.8 (95% CI, 0.4 to 7.9); fever, 1.8 (95% CI, 0.8 to 4.1); and electric blanket, 1.2 (95% CI, 0.5 to 2.6). When only hot tub, sauna, and fever were considered and the women's exposure to each tallied, compared with no heat exposure, the RR for NTDs increased from 1.9 (95% CI, 0.9 to 3.7) after one type of heat exposure to 6.2 (95% CI, 2.2 to 17.2) after two types of heat exposure. Conclusions. —Exposure to heat in the form of hot tub, sauna, or fever in the first trimester of pregnancy was associated with an increased risk for NTDs. Hot tub exposure appeared to have the strongest effect of any single heat exposure. Exposure to electric blanket was not materially associated with increased risk for NTDs. (JAMA. 1992;268:882-885)
JAMA – American Medical Association
Published: Aug 19, 1992
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