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References (11)
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F. Smith, T. Butler, S. Cohan, P. Schein (1977)
Laetrile toxicity: a report of two cases.JAMA, 238 13
- Publisher
- American Medical Association
- Copyright
- Copyright © 1978 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
- ISSN
- 0098-7484
- eISSN
- 1538-3598
- DOI
- 10.1001/jama.1978.03280370039021
- Publisher site
- See Article on Publisher Site
Abstract
Dogs were fed laetrile and fresh, sweet almonds under various conditions. The doses of laetrile were similar to those prescribed for patients with cancer and ranged on a basis of gram to square meter from an equivalent of the oral dose for man to five times this dose. Six of the ten dogs died of cyanide poisoning. One dog recovered, and three dogs, at the time of sacrifice, demonstrated various levels of neurologic impairment, ranging from difficulty in walking to coma. These studies demonstrate that oral laetrile is highly toxic when taken with some common table foods. We predict that there will be an increased incidence of cyanide poisoning in man as laetrile becomes more readily available. (JAMA 239:943-947, 1978)
Journal
JAMA – American Medical Association
Published: Mar 6, 1978