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PENICILLINASE THERAPY-CLINICAL REPORT OF SEVERE REACTIONS

PENICILLINASE THERAPY-CLINICAL REPORT OF SEVERE REACTIONS Penicillinase, an enzyme that destroys penicillin in vivo as well as in vitro, was discovered in 1940. It is produced by bacterial cultures of various strains of staphylococci, Escherichia coli, and Bacillus cereus and is thought to hydrolyze penicillin to penicilloic acid, which is not antigenic. Becker,1 Minno and Davis,2 and Zimmerman3 have reported it as an effective treatment for patients who react unfavorably to penicillin, but local and febrile reactions to it have occurred. Minno and Davis2 reported that most patients complained of local pain and tenderness at the site of injection; the area frequently remaining painful for 24 hours. Zimmerman3 observed transient soreness at the site of injection in one-third of the patients treated; about one-fifth had severe soreness. He therefore recommended that the injection be given intragluteally and deeply. In 5% there was an occasional, mild, febrile reaction which lasted a few http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

PENICILLINASE THERAPY-CLINICAL REPORT OF SEVERE REACTIONS

Reisch, Milton
JAMA , Volume 169 (6) – Feb 7, 1959
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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1959.73000230004011b
Publisher site
See Article on Publisher Site

Abstract

Penicillinase, an enzyme that destroys penicillin in vivo as well as in vitro, was discovered in 1940. It is produced by bacterial cultures of various strains of staphylococci, Escherichia coli, and Bacillus cereus and is thought to hydrolyze penicillin to penicilloic acid, which is not antigenic. Becker,1 Minno and Davis,2 and Zimmerman3 have reported it as an effective treatment for patients who react unfavorably to penicillin, but local and febrile reactions to it have occurred. Minno and Davis2 reported that most patients complained of local pain and tenderness at the site of injection; the area frequently remaining painful for 24 hours. Zimmerman3 observed transient soreness at the site of injection in one-third of the patients treated; about one-fifth had severe soreness. He therefore recommended that the injection be given intragluteally and deeply. In 5% there was an occasional, mild, febrile reaction which lasted a few

Journal

JAMA – American Medical Association

Published: Feb 7, 1959

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