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WHERE DOES FIBRINOGEN ARISE?

WHERE DOES FIBRINOGEN ARISE? There are few protective devices of the organism more beneficent than the reaction by which fibrinogen, the soluble protein of the circulating blood, is transformed into the insoluble fibrin, which forms the basis of blood clots and prevents continued hemorrhage after injury to blood vessels. Now and then the clot-forming mechanism fails for some reason; and not a little consideration has been devoted in the past to the possible factors concerned in extravascular coagulation, that the occurrence of the latter might be assured or promoted whenever the normal course of the process was threatened. Thus, it has become known that calcium is somehow involved in the chemical transformations leading to clot formation; and other agencies, respectively promoting or inhibiting it, may be involved in addition to fibrinogen. The latter is obviously the factor of preeminent importance and consequently one with respect to which our information should be made as complete http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

WHERE DOES FIBRINOGEN ARISE?

JAMA , Volume 85 (7) – Aug 15, 1925
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WHERE DOES FIBRINOGEN ARISE?

Abstract


There are few protective devices of the organism more beneficent than the reaction by which fibrinogen, the soluble protein of the circulating blood, is transformed into the insoluble fibrin, which forms the basis of blood clots and prevents continued hemorrhage after injury to blood vessels. Now and then the clot-forming mechanism fails for some reason; and not a little consideration has been devoted in the past to the possible factors concerned in extravascular coagulation, that...
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Publisher
American Medical Association
Copyright
Copyright © 1925 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1925.02670070039017
Publisher site
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Abstract

There are few protective devices of the organism more beneficent than the reaction by which fibrinogen, the soluble protein of the circulating blood, is transformed into the insoluble fibrin, which forms the basis of blood clots and prevents continued hemorrhage after injury to blood vessels. Now and then the clot-forming mechanism fails for some reason; and not a little consideration has been devoted in the past to the possible factors concerned in extravascular coagulation, that the occurrence of the latter might be assured or promoted whenever the normal course of the process was threatened. Thus, it has become known that calcium is somehow involved in the chemical transformations leading to clot formation; and other agencies, respectively promoting or inhibiting it, may be involved in addition to fibrinogen. The latter is obviously the factor of preeminent importance and consequently one with respect to which our information should be made as complete

Journal

JAMA – American Medical Association

Published: Aug 15, 1925

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