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CLINICAL APPLICATION OF THE BROMSULPHALEIN TEST FOR HEPATIC FUNCTION

CLINICAL APPLICATION OF THE BROMSULPHALEIN TEST FOR HEPATIC FUNCTION Since the introduction, three years ago, of a method of estimating hepatic function by determining the rate of removal of phenoltetrachlorphthalein from the blood stream,1 this procedure has been widely used in the clinic. Sufficient experience has been gained to indicate that this method affords several improvements over the classic liver function tests. First, it is specific, and, if properly performed, abnormal results have invariably meant a disturbance in hepatic function. The specificity of a test is a valuable requisite and greatly enhances the clinical reliance that may be placed on it. Secondly, it is comparatively free from technical error and is not difficult to perform. Thirdly, it affords a quantitative measurement of the severity of impaired function. This has been proved experimentally, and clinically it is evidenced in studying cases of acute liver disease (catarrhal and arsphenamin jaundice and eclampsia), in which successive stages of functional repair may http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

CLINICAL APPLICATION OF THE BROMSULPHALEIN TEST FOR HEPATIC FUNCTION

ROSENTHAL, SANFORD M.; WHITE, EDWIN C.
JAMA , Volume 84 (15) – Apr 11, 1925
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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1925 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1925.02660410020008
Publisher site
See Article on Publisher Site

Abstract

Since the introduction, three years ago, of a method of estimating hepatic function by determining the rate of removal of phenoltetrachlorphthalein from the blood stream,1 this procedure has been widely used in the clinic. Sufficient experience has been gained to indicate that this method affords several improvements over the classic liver function tests. First, it is specific, and, if properly performed, abnormal results have invariably meant a disturbance in hepatic function. The specificity of a test is a valuable requisite and greatly enhances the clinical reliance that may be placed on it. Secondly, it is comparatively free from technical error and is not difficult to perform. Thirdly, it affords a quantitative measurement of the severity of impaired function. This has been proved experimentally, and clinically it is evidenced in studying cases of acute liver disease (catarrhal and arsphenamin jaundice and eclampsia), in which successive stages of functional repair may

Journal

JAMA – American Medical Association

Published: Apr 11, 1925

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