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/lp/american-medical-association/suggestion-for-the-avoidance-of-the-wassermann-fast-state-in-the-vzzpO0FIyr
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- Publisher
- American Medical Association
- Copyright
- Copyright © 1921 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
- ISSN
- 0098-7484
- eISSN
- 1538-3598
- DOI
- 10.1001/jama.1921.92630510002011a
- Publisher site
- See Article on Publisher Site
Abstract
Ever since a permanently negative Wassermann test has been considered a necessary requisite before a case of syphilis can be considered as cured, the status of the "Wassermann-fast" case has caused no little doubt and anxiety. The following statements, which refer to old cases of syphilis, deal with the early detection of the development of the Wassermann-fast state, its probable cause and significance, and the means of its prevention. By using a modification of the usual technic of the routine Wassermann test, it is possible to measure in number of complement-binding units the power of any positive serum to bind complement and to demonstrate the effect any drug may have on this power. Briefly, the modification of technic consists in a very exact method of standardizing the complement and in the use of serial dilutions of the serum to be tested so that the result of
Journal
JAMA – American Medical Association
Published: Dec 17, 1921