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Preresection Chemotherapy Improves Survival for Children With Askin Tumors

Preresection Chemotherapy Improves Survival for Children With Askin Tumors Abstract Objective: To test whether patients with Askin tumor treated with aggressive neoadjuvant chemotherapy have a better clinical outcome. Design: Retrospective case series. Setting: Pediatric referral center. Patients: All children diagnosed with malignant small-cell tumors of the chest wall (Askin tumor) and treated from 1975 to September 1987 (phase 1, n=6) and from September 1987 to the present (phase 2, n=9). Main Outcome Measures: Survival as a function of extent of disease and response to therapy as measured by tumor volume, survival, and recurrence. Results: All phase 2 patients had significant reduction of tumor volume and improved survival by Kaplan-Meier estimates compared with phase 1 patients. No phase 1 patients are still alive. Conclusion: Patients with Askin tumor treated with aggressive preresection chemotherapy have smaller tumors to resect and improved survival.Arch Surg. 1996;131:877-880 References 1. Shamberger RC, Grier HE. Chest wall tumors on infants and children . Semin Pediatr Surg . 1994;3:267-276. 2. Bourque MD, Di Lorenzo M, Collin PP, Russo P, Laberge JM, Moir C. Malignant small-cell tumor of the thoracopulmonary region: Askin tumor . J Pediatr Surg . 1989;24:1079-1083.Crossref 3. Shamberger RC, Tarbell NJ, Perez-Atayde AR, Grier HE. Malignant small round cell tumor (Ewing's-PNET) of the chest wall in children . J Pediatr Surg . 1994; 29:179-185.Crossref 4. Burt M, Karpeh M, Ukoha O, et al. Medical tumors of the chest wall: solitary plasmacytoma and Ewing's sarcoma . J Thorac Cardiovasc Surg . 1993;105:89-96. 5. Harvey JC, Bergland R, Pisch J, et al. Superior results with complete resection of Askin's tumor . Semin Surg Oncol . 1993;9:156-159.Crossref 6. von Schlippe M, Whelan JS. Primitive neuroectodermal tumour of the chest wall . Ann Oncol . 1995;6:395-401. 7. Askin FB, Rosai J, Sibley RK, Dehner LP, McAlister WH. Maligant small cell tumor of the thoracopulmonary region in childhood . Cancer . 1979;43:2438-2451.Crossref 8. Sarkar MR, Bahr R. The Askin tumor . Chirurg . 1992;63:973-976. 9. Winkler K, Beron G, Delling G, et al. Neoadjuvant chemotherapy of osteosarcoma: results of a randomized cooperative trial (COSS-82) with salvage chemotherapy based on histologic tumor response . J Clin Oncol . 1988;6:329-337. 10. Bacci G, Picci P, Ferrari S. Primary chemotherapy and delayed surgery for nonmetastatic osteosarcoma of the extremity: results of 164 patients preoperatively treated with high doses of methotrexate, followed by cisplatin and doxorubicin . Cancer . 1993;72:3227-3238.Crossref 11. Seemayer TA, Vekemans M, de Chadarevian JP. Histologic and cytogenetic findings in a malignant tumor of the chest wall and lung (Askin's tumor) . Virchows Arch . 1985;408:289-296.Crossref 12. Taylor C, Patel K, Jones T, Kiely F, De Stavola BL, Sheer D. Diagnosis of Ewing's sarcoma and peripheral neuroectodermal tumour based on the detection of t(11; 22) using fluorescence in situ hybridization . Br J Cancer . 1993;67:128-133.Crossref 13. Boyer MW, Moertel CL, Priests R. Use of intracavitary cisplatin for the treatment of childhood solid tumors in the chest or abdominal cavity . J Clin Oncol . 1995;13:631-636. 14. Filler RM, Ehrlich PF, Greenberg ML, Babyn PS. Pre-operative chemotherapy in hepatoblastoma . Surgery . 1991;110:591-596. 15. Ritchey ML, Kelalis PP, Hasse GM, Shochat SJ, Green DM, D'Angio G. Preoperative therapy for intracaval and atrial extension of Wilm's tumor . Cancer . 1993;71:4104-4110.Crossref 16. Castel V, Badal MD, Bezanilla JL, et al. Treatment of stage III neuroblastoma with emphasis on intensive induction chemotherapy: a report from the neuroblastoma group of the Spanish Society of Pediatric Oncology . Med Pediatr Oncol . 1995;24:29-35.Crossref 17. Kar S, Carr BI. Detection of liver cells in peripheral blood of patients with advanced stage hepatocellular carcinoma . Hepatology . 1995;21:403-407. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Preresection Chemotherapy Improves Survival for Children With Askin Tumors

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References (19)

Publisher
American Medical Association
Copyright
Copyright © 1996 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1996.01430200087015
Publisher site
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Abstract

Abstract Objective: To test whether patients with Askin tumor treated with aggressive neoadjuvant chemotherapy have a better clinical outcome. Design: Retrospective case series. Setting: Pediatric referral center. Patients: All children diagnosed with malignant small-cell tumors of the chest wall (Askin tumor) and treated from 1975 to September 1987 (phase 1, n=6) and from September 1987 to the present (phase 2, n=9). Main Outcome Measures: Survival as a function of extent of disease and response to therapy as measured by tumor volume, survival, and recurrence. Results: All phase 2 patients had significant reduction of tumor volume and improved survival by Kaplan-Meier estimates compared with phase 1 patients. No phase 1 patients are still alive. Conclusion: Patients with Askin tumor treated with aggressive preresection chemotherapy have smaller tumors to resect and improved survival.Arch Surg. 1996;131:877-880 References 1. Shamberger RC, Grier HE. Chest wall tumors on infants and children . Semin Pediatr Surg . 1994;3:267-276. 2. Bourque MD, Di Lorenzo M, Collin PP, Russo P, Laberge JM, Moir C. Malignant small-cell tumor of the thoracopulmonary region: Askin tumor . J Pediatr Surg . 1989;24:1079-1083.Crossref 3. Shamberger RC, Tarbell NJ, Perez-Atayde AR, Grier HE. Malignant small round cell tumor (Ewing's-PNET) of the chest wall in children . J Pediatr Surg . 1994; 29:179-185.Crossref 4. Burt M, Karpeh M, Ukoha O, et al. Medical tumors of the chest wall: solitary plasmacytoma and Ewing's sarcoma . J Thorac Cardiovasc Surg . 1993;105:89-96. 5. Harvey JC, Bergland R, Pisch J, et al. Superior results with complete resection of Askin's tumor . Semin Surg Oncol . 1993;9:156-159.Crossref 6. von Schlippe M, Whelan JS. Primitive neuroectodermal tumour of the chest wall . Ann Oncol . 1995;6:395-401. 7. Askin FB, Rosai J, Sibley RK, Dehner LP, McAlister WH. Maligant small cell tumor of the thoracopulmonary region in childhood . Cancer . 1979;43:2438-2451.Crossref 8. Sarkar MR, Bahr R. The Askin tumor . Chirurg . 1992;63:973-976. 9. Winkler K, Beron G, Delling G, et al. Neoadjuvant chemotherapy of osteosarcoma: results of a randomized cooperative trial (COSS-82) with salvage chemotherapy based on histologic tumor response . J Clin Oncol . 1988;6:329-337. 10. Bacci G, Picci P, Ferrari S. Primary chemotherapy and delayed surgery for nonmetastatic osteosarcoma of the extremity: results of 164 patients preoperatively treated with high doses of methotrexate, followed by cisplatin and doxorubicin . Cancer . 1993;72:3227-3238.Crossref 11. Seemayer TA, Vekemans M, de Chadarevian JP. Histologic and cytogenetic findings in a malignant tumor of the chest wall and lung (Askin's tumor) . Virchows Arch . 1985;408:289-296.Crossref 12. Taylor C, Patel K, Jones T, Kiely F, De Stavola BL, Sheer D. Diagnosis of Ewing's sarcoma and peripheral neuroectodermal tumour based on the detection of t(11; 22) using fluorescence in situ hybridization . Br J Cancer . 1993;67:128-133.Crossref 13. Boyer MW, Moertel CL, Priests R. Use of intracavitary cisplatin for the treatment of childhood solid tumors in the chest or abdominal cavity . J Clin Oncol . 1995;13:631-636. 14. Filler RM, Ehrlich PF, Greenberg ML, Babyn PS. Pre-operative chemotherapy in hepatoblastoma . Surgery . 1991;110:591-596. 15. Ritchey ML, Kelalis PP, Hasse GM, Shochat SJ, Green DM, D'Angio G. Preoperative therapy for intracaval and atrial extension of Wilm's tumor . Cancer . 1993;71:4104-4110.Crossref 16. Castel V, Badal MD, Bezanilla JL, et al. Treatment of stage III neuroblastoma with emphasis on intensive induction chemotherapy: a report from the neuroblastoma group of the Spanish Society of Pediatric Oncology . Med Pediatr Oncol . 1995;24:29-35.Crossref 17. Kar S, Carr BI. Detection of liver cells in peripheral blood of patients with advanced stage hepatocellular carcinoma . Hepatology . 1995;21:403-407.

Journal

Archives of Surgery – American Medical Association

Published: Aug 1, 1996

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