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B. Echtenacher, W. Falk, D. Männel, P. Krammer (1990)
Requirement of endogenous tumor necrosis factor/cachectin for recovery from experimental peritonitis.Journal of immunology, 145 11
I. Brook (1989)
In vitro susceptibility and in vivo efficacy of antimicrobials in the treatment of Bacteroides fragilis-Escherichia coli infection in mice.The Journal of infectious diseases, 160 4
A. Waage, A. Halstensen, T. Espevik (1987)
ASSOCIATION BETWEEN TUMOUR NECROSIS FACTOR IN SERUM AND FATAL OUTCOME IN PATIENTS WITH MENINGOCOCCAL DISEASEThe Lancet, 329
H. Michie, D. Wilmore (1990)
Sepsis and tumor necrosis factor--bedfellows that cannot be ignored.Annals of surgery, 212 6
B. Beutler, I. Milsark, A. Cerami (1985)
Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin.Science, 229 4716
M. Marano, Y. Fong, L. Moldawer, H. Wei, S. Calvano, K. Tracey, P. Barie, K. Manogue, A. Cerami, Shires Gt (1990)
Serum cachectin/tumor necrosis factor in critically ill patients with burns correlates with infection and mortality.Surgery, gynecology & obstetrics, 170 1
A. Ayala, J. Kisala, J. Felt, M. Perrin, I. Chaudry (1992)
Does endotoxin tolerance prevent the release of inflammatory monokines (interleukin 1, interleukin 6, or tumor necrosis factor) during sepsis?Archives of surgery, 127 2
B. Sheppard, D. Fraker, J. Norton (1989)
Prevention and treatment of endotoxin and sepsis lethality with recombinant human tumor necrosis factor.Surgery, 106 2
H. Alexander, B. Sheppard, J. Jensen, H. Langstein, C. Buresh, D. Venzon, E. Walker, D. Fraker, M. Stovroff, J. Norton (1991)
Treatment with recombinant human tumor necrosis factor-alpha protects rats against the lethality, hypotension, and hypothermia of gram-negative sepsis.The Journal of clinical investigation, 88 1
A. Cross, J. Sadoff, N. Kelly, E. Bernton, P. Gemski (1989)
Pretreatment with recombinant murine tumor necrosis factor alpha/cachectin and murine interleukin 1 alpha protects mice from lethal bacterial infectionThe Journal of Experimental Medicine, 169
D. Hopkin (1978)
FRAPPER FORT OU FRAPPER DOUCEMENT: A GRAM-NEGATIVE DILEMMAThe Lancet, 312
K. Tracey, Y. Fong, D. Hesse, K. Manogue, Annette Lee, G. Kuo, S. Lowry, A. Cerami (1987)
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemiaNature, 330
David Livingston, M. Malangoni, Gerald Sonnenfeld (1988)
Immune enhancement by tumor necrosis factor-alpha improves antibiotic efficacy after hemorrhagic shock.The Journal of trauma, 29 7
H. Michie, K. Manogue, D. Spriggs, A. Revhaug, S. O'dwyer, C. Dinarello, A. Cerami, S. Wolff, D. Wilmore (1988)
Detection of circulating tumor necrosis factor after endotoxin administration.The New England journal of medicine, 318 23
C. Rock, S. Lowry (1991)
Tumor necrosis factor-aJournal of Surgical Research
A. Exley, J. Cohen, W. Buurman, R. Owen, J. Lumley, G. Hanson, J.M Aulakh, M. Bodmer, S. Stephens, A. Riddell, M. Perry (1990)
Monoclonal antibody to TN F in severe septic shockThe Lancet, 335
Perrin MM Ayala A (1990)
Sepsis selectively activates peritoneal but not alveolar macrophages to release inflammatory mediators (IL-1, IL-6 and TNF)Surg Forum, 41
Compagnon A Reilly J (1950)
Les accidents du traitement des fièvres typhoïdes par la chloromycétineAnn Med, 51
B. Sheppard, J. Norton (1991)
Tumor necrosis factor and interleukin-1 protection against the lethal effects of tumor necrosis factor.Surgery, 109 6
O. Zamir, P. Hasselgren, S. Kunkel, J. Frederick, T. Higashiguchi, J. Fischer (1992)
Evidence that tumor necrosis factor participates in the regulation of muscle proteolysis during sepsis.Archives of surgery, 127 2
G. Bagby, Kirby Plessala, L. Wilson, James Thompson, S. Nelson (1991)
Divergent efficacy of antibody to tumor necrosis factor-alpha in intravascular and peritonitis models of sepsis.The Journal of infectious diseases, 163 1
Mahmoud Mustafa, Octavio Ramilo, Jussi Mertsola, Richard Risser, Bruce Beutler, Eric Hansen, George McCracken (1989)
Modulation of inflammation and cachectin activity in relation to treatment of experimental Hemophilus influenzae type b meningitis.The Journal of infectious diseases, 160 5
H. Goto, S. Nakamura (1980)
Liberation of endotoxin from Escherichia coli by addition of antibiotics.The Japanese journal of experimental medicine, 50 1
D. Dunn (1990)
Development and potential use of antibody directed against lipopolysaccharide for the treatment of gram-negative bacterial sepsis.The Journal of trauma, 30 12 Suppl
J. Mayoral, D. Dunn (1990)
Cross-reactive murine monoclonal antibodies directed against the core/lipid A region of endotoxin inhibit production of tumor necrosis factor.The Journal of surgical research, 49 4
S. Opal, Alan Cross, Niamh Kelly, J. Sadoff, M. Bodmer, J. Palardy, Gary Victor (1990)
Efficacy of a monoclonal antibody directed against tumor necrosis factor in protecting neutropenic rats from lethal infection with Pseudomonas aeruginosa.The Journal of infectious diseases, 161 6
D. Simon, G. Koenig, G. Trenholme (1991)
Differences in release of tumor necrosis factor from THP-1 cells stimulated by filtrates of antibiotic-killed Escherichia coli.The Journal of infectious diseases, 164 4
Adams RB Sawyer RG (1991)
Interleukin-4 (IL-4) prevents mortality from acute but not chronic peritoneal infections and induces an accelerated tumor necrosis factor alpha (TNF) responseSurg Forum, 42
Livingston DH Malangoni MA (1990)
Interferon gamma and tumor necrosis factor alphaArch Surg, 125
M. Malangoni, D. Livingston, G. Sonnenfeld, H. Polk (1990)
Interferon gamma and tumor necrosis factor alpha. Use in gram-negative infection after shock.Archives of Surgery, 125
J. Shenep, Kathryn Mogan (1984)
Kinetics of endotoxin release during antibiotic therapy for experimental gram-negative bacterial sepsis.The Journal of infectious diseases, 150 3
J. Mayoral, Cyril Schweich, D. Dunn (1990)
Decreased tumor necrosis factor production during the initial stages of infection correlates with survival during murine gram-negative sepsis.Archives of surgery, 125 1
J. Mathison, Eleonora Wolfson, R. Ulevitch (1988)
Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits.The Journal of clinical investigation, 81 6
R. Sawyer, R. Adams, M. Spengler, T. Pruett (1991)
Preexposure of the peritoneum to live bacteria increases later mixed intraabdominal abscess formation and delays mortality.The Journal of infectious diseases, 163 3
Lerner Hinshaw, P. Tekamp-Olson, A. Chang, P. Lee, Fletcher Taylor, Cynthia Murray, G. Peer, T. Emerson, R. Passey, G. Kuo (1990)
Survival of primates in LD100 septic shock following therapy with antibody to tumor necrosis factor (TNF alpha).Circulatory shock, 30 3
M. Täuber, M. Täuber, Atel Shibl, C. Hackbarth, C. Hackbarth, J. Larrick, J. Larrick, M. Sande, M. Sande (1987)
Antibiotic therapy, endotoxin concentration in cerebrospinal fluid, and brain edema in experimental Escherichia coli meningitis in rabbits.The Journal of infectious diseases, 156 3
Sawyer RG Adams RB (1991)
Mixed bacterial and fungal intraperitoneal infections: antibacterial agents alone fail to reduce mortalitySurg Forum, 42
Abstract • The systemic tumor necrosis factor (TNF) response has been extensively studied during infection. In addition, antibiotics that cause cell-wall lysis have been associated with endotoxinemia and, therefore, could trigger TNF release. We studied the effects of pretreatment with cefoxitin and/or anti-TNF antibody on mortality and early (90 minutes) and delayed (6 hours) serum TNF levels in a murine model of mixed Escherichia coli/Bacteroides fragilis peritonitis. At low and intermediate inocula levels, cefoxitin, but not anti-TNF antibody, prevented death, and low serum TNF levels were noted in all groups. At the highest inoculum level, mortality was uniform in control, cefoxitin, and anti-TNF antibody groups, and a significant elevation in serum TNF levels was seen only at the 6-hour point in animals receiving cefoxitin. The addition of anti-TNF antibody to cefoxitin at this inoculum level abrogated the 6-hour rise in serum TNF levels and reduced mortality to 40%. These results emphasize that the cytokine response in disease is dependent on both the nature of the insult and other forms of therapeutic interventions. (Arch Surg. 1993;128:73-78) References 1. Michie HR, Wilmore DW. Sepsis and tumor necrosis factor: bedfellows that cannot be ignored . Ann Surg . 1990;212:653-654.Crossref 2. Rock CS, Lowry SF. Tumor necrosis factor-a . J Surg Res . 1991;51:434-445.Crossref 3. Michie HR, Maogue KR, Spriggs DR, et al. Detection of circulating tumor necrosis factor after endotoxin administration . N Engl J Med . 1988;318: 1481-1486.Crossref 4. Beutler B, Milsark IW, Cerami AC. Passive immunization against cachectin/tumor necrosis factor protects mice from the lethal effect of endotoxin . Science . 1985;229:869-871.Crossref 5. Tracey KJ, Fong Y, Hesse DC, et al. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteremia . Nature . 1987;330: 662-664.Crossref 6. Mathison JC, Wolfson E, Elevitch RJ. Participation of tumor necrosis factor in the mediation of gram-negative bacterial lipopolysaccharide-induced injuries in rabbits . J Clin Invest . 1988;81:1925-1937.Crossref 7. Opal SM, Cross AS, Kelly NM, et al. Efficacy of a monoclonal antibody directed against tumor necrosis factor in protecting neutropenic rats from lethal infection with Pseudomonas aeruginosa . J Infect Dis . 1990;161:1148-1152.Crossref 8. Hinshaw LB, Tekamp-Olson P, Chang AC, et al. Survival of primates in LD100 septic shock following therapy with antibody to tumor necrosis factor . Circ Shock . 1990;30:279-292. 9. Mayoral JL, Schweich CJ, Dunn DL. Decreased tumor necrosis factor production during the initial stages of infection correlates with survival during murine gram-negative sepsis . Arch Surg . 1990;125:24-27.Crossref 10. Mayoral JL, Dunn DL. Cross-negative murine monoclonal antibodies directed against the core/lipid A region of endotoxin inhibit production of tumor necrosis factor . J Surg Res . 1990;49:287-292.Crossref 11. Dunn DL. Development and potential use of antibody directed against lipopolysaccharide for the treatment of gram-negative bacterial sepsis . J Trauma . 1990;30:S100-S106.Crossref 12. Waage A, Halstensen A, Espevik T. Association between tumor necrosis factor in serum and fatal outcome in patients with meningococcal disease . Lancet . 1987;1:355-357.Crossref 13. Marano MA, Fong Y, Moldawer LL, et al. Serum cachectin/tumor necrosis factor in critically ill patients with burns correlates with infection and mortality . Surg Gynecol Obstet . 1990;170:32-36. 14. Exley AR, Cohen J, Buurman W, et al. Monoclonal antibody to TNF in severe septic shock . Lancet . 1990;335:1275-1277.Crossref 15. Reilly J, Compagnon A, Tournier P, Bastin R, Du Buit H. Les accidents du traitement des fièvres typhoïdes par la chloromycétine; étude expérimentale et déductions thérepeutiques . Ann Med . 1950;51:597-654. 16. Hopkin DAB. Frapper fort ou frapper doucement: a gram-negative dilemma . Lancet . 1978;2:1193-1194. 17. Goto H, Nukamura S. Liberation of endotoxin from Escherichia coli by addition of antibiotics . Jpn J Exp Med . 1980;50:35-39. 18. Shenep JL, Mogan KA. Kinetics of endotoxin release during antibiotic therapy for experimental gram-negative bacterial sepsis . J Infect Dis . 1984; 150:380-388.Crossref 19. Tauber MG, Shibl AM, Hackbarth CJ, Larrick JW, Sande MA. Antibiotic therapy, endotoxin concentration in cerebrospinal fluid, and brain edema in experimental Escherichia coli meningitis in rabbits . J Infect Dis . 1987; 156:456-462.Crossref 20. Simon DM, Koenig G, Trenholme GM. Differences in release of tumor necrosis factor from THP-1 cells stimulated by filtrates of antibiotic-killed Escherichia coli . J Infect Dis . 1991;164:800-802.Crossref 21. Mustafa MM, Ramilo O, Mertsola J, et al. Modulation of inflammation and cachectin activity in relation to treatment of experimental Haemophilus influenzae type B meningitis . J Infect Dis . 1989;160:818-825.Crossref 22. Livingston DH, Malangoni MA, Sonnenfeld G. Immune enhancement by tumor necrosis factor-alpha improves antibiotic efficacy after hemorrhagic shock . J Trauma . 1989;29:967-971.Crossref 23. Malangoni MA, Livingston DH, Sonnenfeld G, Polk HC Jr. Interferon gamma and tumor necrosis factor alpha . Arch Surg . 1990;125:444-446.Crossref 24. Sawyer RG, Adams RB, May AK, Rosenlof LK, Spengler MD, Pruett TL. Interleukin-4 (IL-4) prevents mortality from acute but not chronic peritoneal infections and induces an accelerated tumor necrosis factor alpha (TNF) response . Surg Forum . 1991;42:93-96. 25. Brook I. In vitro susceptibility and in vivo efficacy of antimicrobials in the treatment of Bacteroides fragilis-Escherichia coli infection in mice . J Infect Dis . 1989;160:651-656.Crossref 26. Adams RB, Sawyer RG, May AK, Spengler MD, Pruett TL. Mixed bacterial and fungal intraperitoneal infections: antibacterial agents alone fail to reduce mortality . Surg Forum . 1991;42:72-73. 27. Sawyer RG, Adams RB, Spengler MD, Pruett TL. Pre-exposure of the peritoneum to live bacteria increases later mixed intraabdominal abscess formation and alters mortality . J Infect Dis . 1991;163:664-667.Crossref 28. Cross AS, Sadoff JC, Kelly N, Bernton E, Gemski P. Pretreatment with recombinant murine tumor necrosis factor-alpha/cachectin and murine interleukin-1 alpha protects mice from lethal bacterial infection . J Exp Med . 1989;169:2021-2027.Crossref 29. Sheppard BC, Fraker DL, Norton JA. Prevention and treatment of endotoxin and sepsis lethality with recombinant human tumor necrosis factor . Surgery . 1989;106:156-161. 30. Echtenacher B, Falk W, Männel DN, Krammer PH. Requirement of endogenous tumor necrosis factor/cachectin for recovery from experimental peritonitis . J Immunol . 1990;145:3762-3766. 31. Bagby GJ, Plessala KJ, Wilson LA, Thompson JJ, Nelson S. Divergent efficacy of antibody to tumor necrosis-alpha in intravascular and peritonitis models of sepsis . J Infect Dis . 1991;163:83-88.Crossref 32. Sheppard BC, Norton JA. Tumor necrosis factor and interleukin-1 protection against the lethal effects of tumor necrosis factor . Surgery . 1991; 109:698-705. 33. Alexander HR, Sheppard BC, Jansen JC, et al. Treatment with recombinant tumor necrosis factor-alpha protects rats against the lethality, hypotension, and hypothermia of gram-negative sepsis . J Clin Invest . 1991;88: 34-39.Crossref 34. Ayala A, Perrin MM, Kisala J, Ertel W, Chaudry IH. Sepsis selectively activates peritoneal but not alveolar macrophages to release inflammatory mediators (IL-1, IL-6 and TNF) . Surg Forum . 1990;41:117-119. 35. Zamir O, Hasselgren P-O, Kunkel SL, Frederick J, Higashiguchi T, Fischer JE. Evidence that tumor necrosis factor participates in the regulation of muscle proteolysis during sepsis . Arch Surg . 1992;127:170-174.Crossref 36. Ayala A, Kisala JM, Felt JA, Perrin MM, Chaudry IH. Does endotoxin tolerance prevent the release of inflammatory monokines (interleukin 1, interleukin 6, or tumor necrosis factor) during sepsis? Arch Surg . 1992;127: 191-197.Crossref
Archives of Surgery – American Medical Association
Published: Jan 1, 1993
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