Access the full text.
Sign up today, get DeepDyve free for 14 days.
M. WOLF-PEETERS, MD MARIEN, DR MEBIS, M. DESMET, A. St, Katholieke Rafael, Leuven (1980)
A cutaneous apudoma or merkel cell tumor? A morphologically recognizable tumor with a biological and histological malignant aspect in contrast with its clinical behaviorCancer, 46
J. Shaw, E. Rumball (1991)
Merkel cell tumour: Clinical behaviour and treatmentBritish Journal of Surgery, 78
L. Feun, N. Savaraj, S. Legha, Elvio Silva, R. Benjamin, M. Burgess (1988)
Chemotherapy for metastatic merkel cell carcinoma. Review of the M. D. Anderson hospital's experienceCancer, 62
H. Goepfert, D. Remmler, E. Silva, B. Wheeler (1984)
Merkel cell carcinoma (endocrine carcinoma of the skin) of the head and neck.Archives of otolaryngology, 110 11
G. Schaefer, R. Erlandson, C. Urmacher (1982)
A cutaneous neoplasm in the skin of the abdomen that was excised and was followed by the development of bilateral axillary masses.The American Journal of dermatopathology, 4 6
E. Silva, B. Mackay, H. Goepfert, M. Burgess, R. Fields (1984)
Endocrine carcinoma of the skin (Merkel cell carcinoma).Pathology annual, 19 Pt 2
A. Szadowska, L. Woźniak, J. Lasota, I. Giryn, B. Mirecka, H. Wolska (1989)
Neuroendocrine (Merkel cell) carcinoma of the skin: a clinico‐morphological study of 13 casesHistopathology, 15
J. Pacella, M. Ashby, J. Ainslie, C. Minty (1988)
The role of radiotherapy in the management of primary cutaneous neuroendocrine tumors (Merkel cell or trabecular carcinoma): experience at the Peter MacCallum Cancer Institute (Melbourne, Australia).International journal of radiation oncology, biology, physics, 14 6
Tang Ck, C. Toker (1979)
Trabecular carcinoma of the skin: further clinicopathologic and ultrastructural study.The Mount Sinai journal of medicine, New York, 46 5
Moll R Gould V (1985)
Biology of disease: neuroendocrine (Merkel) cells of the skin: hyperplasias, dysplasias, and neoplasmsLab Invest, 52
N. Breslow, D. Cox, D. Oakes (1985)
Analysis of Survival Data.Biometrics, 41
C. Balch (1988)
The role of elective lymph node dissection in melanoma: rationale, results, and controversies.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 6 1
J. Taxy, D. Ettinger, M. Wharam (1980)
Primary small cell carcinoma of the skinCancer, 46
E. Kaplan, P. Meier (1958)
Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 53
C. Hitchcock, K. Bland, Robert Laney, D. Franzini, Brian Harris, E. Copeland (1988)
Neuroendocrine (Merkel Cell) Carcinoma of the Skin: Its Natural History, Diagnosis, and TreatmentAnnals of Surgery, 207
T. Warner, H. Uno, G. Hafez, J. Burgess, C. Bolles, R. Lloyd, Masamichi Oka (1983)
Merkel cells and merkel cell tumors ultrastructure, immunocytochemistry and review of the literatureCancer, 52
Remmler D Goepfert H (1984)
Merkel cell carcinoma (endocrine carcinoma of the skin) of the head and neckArch Otolaryngol Head Neck Surg, 110
Chik‐Kwun Tang, C. Toker (1978)
Trabecular carcinoma of the skin. An ultrastructural studyCancer, 42
J. Raaf, C. Urmacher, W. Knapper, M. Shiu, E. Cheng (1986)
Trabecular (merkel cell) carcinoma of the skin. Treatment of primary, recurrent, and metastatic diseaseCancer, 57
Toker C Tang CK (1979)
Trabecular carcinoma of the skin: further clinicopathologic and ultrastructural studyMt Sinai J Med, 46
S. Knox, D. Kapp (1988)
Hyperthermia and radiation therapy in the treatment of recurrent merkel cell tumorsCancer, 62
C. Wynne, J. Kearsley (1988)
Merkel cell tumor. A chemosensitive skin cancerCancer, 62
M. Wick, J. Goellner, B. Scheithauer, J. Thomas, N. Sánchez, A. Schroeter (1983)
Primary neuroendocrine carcinomas of the skin (Merkel cell tumors). A clinical, histologic, and ultrastructural study of thirteen cases.American journal of clinical pathology, 79 1
M. Marks, R. Kim, M. Salter (1990)
Radiotherapy as an adjunct in the management of merkel cell carcinomaCancer, 65
S. Pilotti, F. Rilke, C. Bartoli, A. Grisotti (1988)
Clinicopathologic correlations of cutaneous neuroendocrine Merkel cell carcinoma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 6 12
C. Toker (1972)
Trabecular carcinoma of the skin.Archives of dermatology, 105 1
R. Sibley, J. Rosai, E. Foucar, L. Dehner, G. Bosl (1980)
Neuroendocrine (Merkel cell) carcinoma of the skin: A histologic and ultrastructural study of two casesThe American Journal of Surgical Pathology, 4
V. Gould, R. Moll, I. Moll, Inchul Lee, W. Franke (1985)
Neuroendocrine (Merkel) cells of the skin: hyperplasias, dysplasias, and neoplasms.Laboratory investigation; a journal of technical methods and pathology, 52 4
Abstract • Seventy patients with Merkel cell carcinoma were treated at Memorial Sloan-Kettering Cancer Center between 1969 and 1989. The overall estimated 5-year survival rate was 64%. Factors predictive of improved survival included head and neck site and negative lymph nodes at presentation. Local recurrence was seen in 18 patients (26%) and did not correlate with patient-, tumor-, or treatment-related variables. Nine patients with local recurrence (50%) were free of disease following aggressive reoperation. Regional nodes were involved at some point during the course of the disease in forty-six patients (66%). Regional lymph node involvement was apparent within 2 years of diagnosis in 40 (87%) of 46 patients in whom it occurred. Systemic disease was nearly uniformly preceded by the appearance of nodal metastases and was uniformly fatal regardless of subsequent therapy. This suggests an orderly "cascade" pattern of spread for this tumor, in which elective regional lymph node dissection may be justified. Our recommendations for treatment include a wide excision of the primary tumor and either elective or early therapeutic regional node dissection. The role of adjuvant radiotherapy or chemotherapy remains unproven. (Arch Surg. 1991;126:1514-1519) References 1. Toker C. Trabecular carcinoma of the skin . Arch Dermatol . 1972;105:107-110.Crossref 2. Tang CK, Toker C. Trabecular carcinoma of the skin: an ultrastructural study . Cancer . 1978;42:2311-2321.Crossref 3. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations . J Am Stat Assoc . 1958;53:457-481.Crossref 4. Cox DR, Oakes D. Analysis of Survival Data . London, England: Chapman & Hall; 1984. 5. De Wolf-Peeter C, Marien K, Mebis J, Desmet V. A cutaneous APUDoma or Merkel cell tumor? a morphologically recognizable tumor with a biological and histological malignant aspect in contrast with its clinical behaviour . Cancer . 1980;46:1810-1816.Crossref 6. Szadowska A, Wozniak L, Lasota J, Giryn I, Mirecka B, Wolska H. Neuroendocrine (Merkel cell) carcinoma of the skin: a clinico-morphological study of 13 cases . Histopathology . 1989;15:483-493.Crossref 7. Goepfert H, Remmler D, Silva EG, Wheeler B. Merkel cell carcinoma (endocrine carcinoma of the skin) of the head and neck . Arch Otolaryngol Head Neck Surg . 1984;110:707-712.Crossref 8. Raaf JH, Urmacher C, Knapper WK, Shiu MH, Cheng EWK. Trabecular (Merkel cell) carcinoma of the skin: treatment of primary, recurrent, and metastatic disease . Cancer . 1986;57:178-182.Crossref 9. Pilotti S, Rilke F, Bartoli C, Grisotti A. Clinicopathologic correlations of cutaneous neuroendocrine Merkel cell carcinoma . J Clin Oncol . 1988;6:1863-1873. 10. Hitchcock CL, Bland KI, Lahey RG, Franzini D, Harris B, Copeland EM. Neuroendocrine (Merkel cell) carcinoma of the skin: its natural history, diagnosis, and treatment . Ann Surg . 1988;207:201-207.Crossref 11. Tang CK, Toker C. Trabecular carcinoma of the skin: further clinicopathologic and ultrastructural study . Mt Sinai J Med . 1979;46:516-523. 12. Sibley RK, Rosai J, Foucar E, Dehner LP, Bosi G. Neuroendocrine (Merkel cell) carcinoma of the skin: a histologic and ultrastructural study of two cases . Am J Surg Pathol . 1980;4:211-221.Crossref 13. Warner TFCS, Uno H, Hafez GR, et al. Merkel cells and Merkel cell tumors: ultrastructural, immunocytochemistry and review of the literature . Cancer . 1983;52:238-245.Crossref 14. Silva EG, Mackay B, Goepfert H, Burgess MA, Fields RS. Endocrine carcinoma of the skin (Merkel cell carcinoma) . Pathol Annu . 1984;19:1-30. 15. Wick MR, Goellner JR, Scheithauer BW, Thomas JR, Sanchez NP, Schroeter AL: Primary neuroendocrine carcinomas of the skin (Merkel cell tumors): a clinical, histologic, and ultrastructural study of thirteen cases . Am J Clin Pathol . 1983;79:6-13. 16. Gould V, Moll R, Moll I, Lee I, Franke W. Biology of disease: neuroendocrine (Merkel) cells of the skin: hyperplasias, dysplasias, and neoplasms . Lab Invest . 1985;52:334-353. 17. Shaw JHF, Rumbull E. Merkel cell tumor: clinical behavior and treatment . Br J Surg . 1991;78:138-142.Crossref 18. Balch CM. The role of elective lymph node dissection in melanoma: rationale, results, and controversies . J Clin Oncol . 1988;6:163-172. 19. Schaefer GD, Erlandson RA, Urmacher C. A cutaneous neoplasm in the skin of the abdomen that was excised and was followed by the development of bilateral axillary masses . Am J Dermatopathol . 1982;4:549-554.Crossref 20. Feun LG, Savaraj N, Legha SS, Silva EG, Benjamin RS, Burgess MA. Chemotherapy for metastatic Merkel cell carcinoma: review of the M.D. Anderson Hospital's experience . Cancer . 1988;62:683-685.Crossref 21. Wynne CJ, Kearsley JH. Merkel cell tumor: a chemosensitive skin cancer . Cancer . 1988;62:28-31.Crossref 22. Marks ME, Kim RY, Salter MM. Radiotherapy as an adjunct in the management of Merkel cell carcinoma . Cancer . 1990;65:60-64.Crossref 23. Knox SJ, Kapp DS. Hyperthermia and radiation therapy in the treatment of recurrent Merkel cell tumors . Cancer . 1988;62:1479-1486.Crossref 24. Pacella J, Ashby M, Ainslie J, Minty C. The role of radiotherapy in the management of primary cutaneous neuroendocrine tumors (Merkel cell or trabecular carcinoma): experience at the Peter MacCallum Cancer Institute (Melbourne, Australia) . Int J Radiat Oncol Biol Phys . 1988;14:1077-1084.Crossref 25. Taxy JB, Ettinger DS, Wharam MD. Primary small cell carcinoma of the skin . Cancer . 1980;46:2308-2311.Crossref
Archives of Surgery – American Medical Association
Published: Dec 1, 1991
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.