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Neuroleptic Malignant Syndrome in a Multiple Trauma Patient

Neuroleptic Malignant Syndrome in a Multiple Trauma Patient Abstract • Neuroleptic malignant syndrome is a little-known adverse reaction to neuroleptic administration characterized by hyperpyrexia, leukocytosis, creatine kinase elevations, muscular rigidity, autonomic dysfunction, and alterations in level of consciousness. Neuroleptic malignant syndrome has an associated 20% mortality but can be reversed when treated with neuroleptic discontinuation and administration of bromocriptine and dantrolene. Early diagnosis in the trauma unit may prevent an extensive workup for presumed sepsis. To our knowledge, neuroleptic malignant syndrome has not previously been reported in a multiple trauma patient. (Arch Surg. 1990;125:274-275) References 1. Petersdorf RG. FUO: how it has changed in 20 years . Hosp Pract . 1985;20:84I-84GG. 2. Smego RA, Durack DT. The neuroleptic malignant syndrome . Arch Intern Med . 1982;142:1183-1185.Crossref 3. Kellam AM. The neuroleptic malignant syndrome, so-called: a survey of the world literature . Br J Psychiatry . 1987;150:752-759.Crossref 4. Shafer WH, Furlan AJ. Neuroleptic malignant syndrome: an unusual cause of fever . Cleve Clin J Med . 1986;53:355-356.Crossref 5. Pope HG, Keck PE, McElroy SL. Frequency and presentation of neuroleptic malignant syndrome in a large psychiatric hospital . Am J Psychiatry . 1986;143:1227-1233. 6. Moyes DB. Malignant hyperpyrexia caused by trimeprazine . Br J Anaesth . 1973;45:1163-1164.Crossref 7. Regestein QR, Alpert JS, Reich P. Sudden catatonic stupor with disastrous outcome . JAMA . 1977;238:618-620.Crossref 8. Morris HH, McCormick WF, Reinarz JA. Neuroleptic malignant syndrome . Arch Neurol . 1980;37:462-463.Crossref 9. McAllister RG Jr. Fever, tachycardia, and hypertension with acute catatonic schizophrenia . Arch Intern Med . 1978;138:1154-1156.Crossref 10. Caroff SN. The neuroleptic malignant syndrome . J Clin Psychiatry . 1980;41:79-83. 11. Konikoff F, Kuritzy A, Jerushalmi Y, Theodok E. Neuroleptic malignant syndrome induced by a single injection of haloperidol . Br Med J . 1984;289:1228-1229.Crossref 12. Henderson VW, Wooten GF. Neuroleptic malignant syndrome: a pathogenic role for dopamine receptor blockade? Neurology . 1981;31:132-137.Crossref 13. Eiser AR, Neff MS, Slifkin RF. Acute myoglobinuric renal failure . Arch Intern Med . 1982;142:601-603.Crossref 14. Granato JE, Stern BJ, Ringel A, et al. Neuroleptic malignant syndrome: successful treatment with dantrolene and bromocriptine . Ann Neurol . 1983;14:89-90.Crossref 15. Gibb WRG, Griffith DNW. Levodopa withdrawal syndrome identical to neuroleptic malignant syndrome . Postgrad Med J . 1986;62:59-60.Crossref 16. Dhib-Jalbut S, Hesselbrock R, Brott T, Silbergeld D. Treatment of the neuroleptic malignant syndrome with bromocriptine . JAMA . 1983;250:484-485.Crossref 17. Zubenko G, Harrison GP. Management of a case of neuroleptic malignant syndrome with bromocriptine . Am J Psychiatry . 1983;140:1619-1620. 18. Goekoop JG, Carbaat PA. Treatment of neuroleptic malignant syndrome with dantrolene . Lancet . 1982;2:49-50.Crossref 19. Coons DJ, Hillman FJ, Marshall RW. Treatment of neuroleptic malignant syndrome with dantrolene sodium: a case report . Am J Psychiatry . 1982;139:944-945. 20. May DC, Morris SW, Stewart RM, Fenton BJ, Gaffney FA. Neuroleptic malignant syndrome: response to dantrolene sodium . Ann Intern Med . 1983;98:183-184.Crossref 21. Mueller PS, Vester JW, Fermaglich J. Neuroleptic malignant syndrome: successful treatment with bromocriptine . JAMA . 1983;249:386-388.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Neuroleptic Malignant Syndrome in a Multiple Trauma Patient

Boorse, Richard C.; Rhodes, Michael
Archives of Surgery , Volume 125 (2) – Feb 1, 1990
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References (28)

Publisher
American Medical Association
Copyright
Copyright © 1990 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1990.01410140152028
Publisher site
See Article on Publisher Site

Abstract

Abstract • Neuroleptic malignant syndrome is a little-known adverse reaction to neuroleptic administration characterized by hyperpyrexia, leukocytosis, creatine kinase elevations, muscular rigidity, autonomic dysfunction, and alterations in level of consciousness. Neuroleptic malignant syndrome has an associated 20% mortality but can be reversed when treated with neuroleptic discontinuation and administration of bromocriptine and dantrolene. Early diagnosis in the trauma unit may prevent an extensive workup for presumed sepsis. To our knowledge, neuroleptic malignant syndrome has not previously been reported in a multiple trauma patient. (Arch Surg. 1990;125:274-275) References 1. Petersdorf RG. FUO: how it has changed in 20 years . Hosp Pract . 1985;20:84I-84GG. 2. Smego RA, Durack DT. The neuroleptic malignant syndrome . Arch Intern Med . 1982;142:1183-1185.Crossref 3. Kellam AM. The neuroleptic malignant syndrome, so-called: a survey of the world literature . Br J Psychiatry . 1987;150:752-759.Crossref 4. Shafer WH, Furlan AJ. Neuroleptic malignant syndrome: an unusual cause of fever . Cleve Clin J Med . 1986;53:355-356.Crossref 5. Pope HG, Keck PE, McElroy SL. Frequency and presentation of neuroleptic malignant syndrome in a large psychiatric hospital . Am J Psychiatry . 1986;143:1227-1233. 6. Moyes DB. Malignant hyperpyrexia caused by trimeprazine . Br J Anaesth . 1973;45:1163-1164.Crossref 7. Regestein QR, Alpert JS, Reich P. Sudden catatonic stupor with disastrous outcome . JAMA . 1977;238:618-620.Crossref 8. Morris HH, McCormick WF, Reinarz JA. Neuroleptic malignant syndrome . Arch Neurol . 1980;37:462-463.Crossref 9. McAllister RG Jr. Fever, tachycardia, and hypertension with acute catatonic schizophrenia . Arch Intern Med . 1978;138:1154-1156.Crossref 10. Caroff SN. The neuroleptic malignant syndrome . J Clin Psychiatry . 1980;41:79-83. 11. Konikoff F, Kuritzy A, Jerushalmi Y, Theodok E. Neuroleptic malignant syndrome induced by a single injection of haloperidol . Br Med J . 1984;289:1228-1229.Crossref 12. Henderson VW, Wooten GF. Neuroleptic malignant syndrome: a pathogenic role for dopamine receptor blockade? Neurology . 1981;31:132-137.Crossref 13. Eiser AR, Neff MS, Slifkin RF. Acute myoglobinuric renal failure . Arch Intern Med . 1982;142:601-603.Crossref 14. Granato JE, Stern BJ, Ringel A, et al. Neuroleptic malignant syndrome: successful treatment with dantrolene and bromocriptine . Ann Neurol . 1983;14:89-90.Crossref 15. Gibb WRG, Griffith DNW. Levodopa withdrawal syndrome identical to neuroleptic malignant syndrome . Postgrad Med J . 1986;62:59-60.Crossref 16. Dhib-Jalbut S, Hesselbrock R, Brott T, Silbergeld D. Treatment of the neuroleptic malignant syndrome with bromocriptine . JAMA . 1983;250:484-485.Crossref 17. Zubenko G, Harrison GP. Management of a case of neuroleptic malignant syndrome with bromocriptine . Am J Psychiatry . 1983;140:1619-1620. 18. Goekoop JG, Carbaat PA. Treatment of neuroleptic malignant syndrome with dantrolene . Lancet . 1982;2:49-50.Crossref 19. Coons DJ, Hillman FJ, Marshall RW. Treatment of neuroleptic malignant syndrome with dantrolene sodium: a case report . Am J Psychiatry . 1982;139:944-945. 20. May DC, Morris SW, Stewart RM, Fenton BJ, Gaffney FA. Neuroleptic malignant syndrome: response to dantrolene sodium . Ann Intern Med . 1983;98:183-184.Crossref 21. Mueller PS, Vester JW, Fermaglich J. Neuroleptic malignant syndrome: successful treatment with bromocriptine . JAMA . 1983;249:386-388.Crossref

Journal

Archives of Surgery – American Medical Association

Published: Feb 1, 1990

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