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Prognostic Significance of Pregnancy in Stage I Melanoma

Prognostic Significance of Pregnancy in Stage I Melanoma Abstract • The clinical course of 66 patients with stage I melanoma, diagnosed during pregnancy, treated in the Division of Surgical Oncology at UCLA, was retrospectively reviewed. These patients were compared with 619 nonpregnant female patients with melanoma. There was no significant difference between the pregnant population and control population with respect to location of the primary tumor, age at diagnosis, Clark's level, mean depth of invasion (pregnant females, 1.24 mm vs control, 1.28 mm), and histologic type. The 5-year survival for the women diagnosed with melanoma during pregnancy and for the entire population was 86% and 87%, respectively. These results demonstrate that women diagnosed with melanoma during pregnancy fare no worse than their nonpregnant counterparts. Criteria other than the theoretical effect of pregnancy on the tumor should be used to counsel patients diagnosed with melanoma during pregnancy. (Arch Surg. 1989;124:1227-1231) References 1. Clark WH Jr, From L, Bernardina EA, et al. The histogenesis and biologic behavior or primary human malignant melanoma of the skin . Cancer Res . 1969;29:705-727. 2. Breslow A. Prognostic factors in the treatment of cutaneous melanoma . J Cutan Pathol . 1979;6:208-212.Crossref 3. Balch CM, Murad TM, Soong SJ, et al. A multifactorial analysis of melanoma: prognostic histopathologic features comparing Clark's and Breslow's staging methods . Ann Surg . 1978;118:732-742.Crossref 4. Riberti C, Marola G, Bertani A. Malignant melanoma: the adverse effect of pregnancy . Br J Plastic Surg . 1981;34:338-339.Crossref 5. Conybeare RC. Malignant melanoma in pregnancy: report of three cases . Obstet Gynecol . 1964;24:451-454. 6. Reintgen DS, McCarthy KS, Vollmer R, Cox E, Seigler HF. Malignant melanoma and pregnancy . Cancer . 1985;55:1340-1344.Crossref 7. Houghton AN, Flannery J, Viola MV. Malignant melanoma of the skin occurring during pregnancy . Cancer . 1981;48:407-410.Crossref 8. Shiu MH, Schottenfeld D, Maclean B, Fortner JG. Adverse effect of pregnancy on melanoma: a reappraisal . Cancer . 1976;37:181-187.Crossref 9. Pack GT, Scharnagel IM. The prognosis for malignant melanoma in the pregnant woman . Cancer . 1951;4:324-334.Crossref 10. Allen EP. Malignant melanoma: spontaneous remission after pregnancy . Br Med J . 1955;2:1067-1068.Crossref 11. Morton DL. Surgical treatment for malignant melanoma . Clin Oncol . 1984;3:517-529. 12. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations . J Am Stat Assoc . 1958;53:457-481.Crossref 13. Urist MM, Balch CM, Soong SJ, et al. Head and neck melanoma in 534 clinical stage I patients: a prognostic factors analysis and results of surgical treatment . Ann Surg . 1984;200:769-775.Crossref 14. Ances IG, Pomerantz S. Serum concentration of B-melanocyte-stimulating hormone in human pregnancy . Am J Obstet Gynecol . 1974;119:1062-1068. 15. Neifeld JP, Lippman ME, Fisher RI. Receptors for steroid hormones in human melanoma . Surg Forum . 1976;27:108-110. 16. Byrd BF, McGanity WJ. Effect of pregnancy on clinical course of malignant melanoma . South Med J . 1954;47:196-200.Crossref 17. Hadley JA. Case of malignant melanoma in pregnancy . J Obstet Gynaecol Br Commonwealth . 1952;59:217-219.Crossref 18. George PA, Fortner JG, Pack GT. Melanoma with pregnancy: a report of 115 cases . Cancer . 1960;13:854-859.Crossref 19. Sanchez JL, Figueroa LD, Rodriguez E. Behavior of melanocytic nevi during pregnancy . Am J Dermatopathol . 1984;6:89-91.Crossref 20. Fouchar E, Bentley TJ, Lauke DW, Rosai J. A histopathologic evaluation of nevocellular nevi in pregnancy . Arch Dermatol . 1985;121:350-354.Crossref 21. Olsen G. The malignant melanoma of the skin: new theories based on a study of 500 cases . Acta Chir Scand . 1966;365:1-222. 22. Bertal V, Evans S, Snaw H, Milton G. Oral contraceptive use and malignant melanoma in Australia . Br J Cancer . 1984;50:681-685.Crossref 23. Beral V, Ramsharan S, Faris R. Malignant melanoma and oral contraceptive use among women in California . Br J Cancer . 1977;36:804-809.Crossref 24. Lopez RE, Bhakoo H, Paolinin NS, Rosen F, Holyoke ED, Goldrosen MH. Effect of estrogen on the growth of B-16 melanoma . Surg Forum . 1978;29:153-154. 25. Rosenberg JC, Assimacopoulos C, Rosenberg SA. The malignant melanoma of hamsters, III: effects of sex and castration on the growth of the transplanted tumor . Ann NY Acad Sci . 1963;100:297-304. 26. Shocket EC, Fortner JG. Melanoma and pregnancy: an experimental evaluation of a clinical impression . Surg Forum . 1958;9:671. 27. Proctor JW, Audair BG, Stockowski L. Endocrine factors and growth of B16 melanoma . JNCI . 1976;57:1197-1198. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Prognostic Significance of Pregnancy in Stage I Melanoma

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References (30)

Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1989.01410100133023
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Abstract

Abstract • The clinical course of 66 patients with stage I melanoma, diagnosed during pregnancy, treated in the Division of Surgical Oncology at UCLA, was retrospectively reviewed. These patients were compared with 619 nonpregnant female patients with melanoma. There was no significant difference between the pregnant population and control population with respect to location of the primary tumor, age at diagnosis, Clark's level, mean depth of invasion (pregnant females, 1.24 mm vs control, 1.28 mm), and histologic type. The 5-year survival for the women diagnosed with melanoma during pregnancy and for the entire population was 86% and 87%, respectively. These results demonstrate that women diagnosed with melanoma during pregnancy fare no worse than their nonpregnant counterparts. Criteria other than the theoretical effect of pregnancy on the tumor should be used to counsel patients diagnosed with melanoma during pregnancy. (Arch Surg. 1989;124:1227-1231) References 1. Clark WH Jr, From L, Bernardina EA, et al. The histogenesis and biologic behavior or primary human malignant melanoma of the skin . Cancer Res . 1969;29:705-727. 2. Breslow A. Prognostic factors in the treatment of cutaneous melanoma . J Cutan Pathol . 1979;6:208-212.Crossref 3. Balch CM, Murad TM, Soong SJ, et al. A multifactorial analysis of melanoma: prognostic histopathologic features comparing Clark's and Breslow's staging methods . Ann Surg . 1978;118:732-742.Crossref 4. Riberti C, Marola G, Bertani A. Malignant melanoma: the adverse effect of pregnancy . Br J Plastic Surg . 1981;34:338-339.Crossref 5. Conybeare RC. Malignant melanoma in pregnancy: report of three cases . Obstet Gynecol . 1964;24:451-454. 6. Reintgen DS, McCarthy KS, Vollmer R, Cox E, Seigler HF. Malignant melanoma and pregnancy . Cancer . 1985;55:1340-1344.Crossref 7. Houghton AN, Flannery J, Viola MV. Malignant melanoma of the skin occurring during pregnancy . Cancer . 1981;48:407-410.Crossref 8. Shiu MH, Schottenfeld D, Maclean B, Fortner JG. Adverse effect of pregnancy on melanoma: a reappraisal . Cancer . 1976;37:181-187.Crossref 9. Pack GT, Scharnagel IM. The prognosis for malignant melanoma in the pregnant woman . Cancer . 1951;4:324-334.Crossref 10. Allen EP. Malignant melanoma: spontaneous remission after pregnancy . Br Med J . 1955;2:1067-1068.Crossref 11. Morton DL. Surgical treatment for malignant melanoma . Clin Oncol . 1984;3:517-529. 12. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations . J Am Stat Assoc . 1958;53:457-481.Crossref 13. Urist MM, Balch CM, Soong SJ, et al. Head and neck melanoma in 534 clinical stage I patients: a prognostic factors analysis and results of surgical treatment . Ann Surg . 1984;200:769-775.Crossref 14. Ances IG, Pomerantz S. Serum concentration of B-melanocyte-stimulating hormone in human pregnancy . Am J Obstet Gynecol . 1974;119:1062-1068. 15. Neifeld JP, Lippman ME, Fisher RI. Receptors for steroid hormones in human melanoma . Surg Forum . 1976;27:108-110. 16. Byrd BF, McGanity WJ. Effect of pregnancy on clinical course of malignant melanoma . South Med J . 1954;47:196-200.Crossref 17. Hadley JA. Case of malignant melanoma in pregnancy . J Obstet Gynaecol Br Commonwealth . 1952;59:217-219.Crossref 18. George PA, Fortner JG, Pack GT. Melanoma with pregnancy: a report of 115 cases . Cancer . 1960;13:854-859.Crossref 19. Sanchez JL, Figueroa LD, Rodriguez E. Behavior of melanocytic nevi during pregnancy . Am J Dermatopathol . 1984;6:89-91.Crossref 20. Fouchar E, Bentley TJ, Lauke DW, Rosai J. A histopathologic evaluation of nevocellular nevi in pregnancy . Arch Dermatol . 1985;121:350-354.Crossref 21. Olsen G. The malignant melanoma of the skin: new theories based on a study of 500 cases . Acta Chir Scand . 1966;365:1-222. 22. Bertal V, Evans S, Snaw H, Milton G. Oral contraceptive use and malignant melanoma in Australia . Br J Cancer . 1984;50:681-685.Crossref 23. Beral V, Ramsharan S, Faris R. Malignant melanoma and oral contraceptive use among women in California . Br J Cancer . 1977;36:804-809.Crossref 24. Lopez RE, Bhakoo H, Paolinin NS, Rosen F, Holyoke ED, Goldrosen MH. Effect of estrogen on the growth of B-16 melanoma . Surg Forum . 1978;29:153-154. 25. Rosenberg JC, Assimacopoulos C, Rosenberg SA. The malignant melanoma of hamsters, III: effects of sex and castration on the growth of the transplanted tumor . Ann NY Acad Sci . 1963;100:297-304. 26. Shocket EC, Fortner JG. Melanoma and pregnancy: an experimental evaluation of a clinical impression . Surg Forum . 1958;9:671. 27. Proctor JW, Audair BG, Stockowski L. Endocrine factors and growth of B16 melanoma . JNCI . 1976;57:1197-1198.

Journal

Archives of Surgery – American Medical Association

Published: Oct 1, 1989

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