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Howland BG Tashjian AH Jr (1970)
Immunoassay of human calcitonin: clinical measurement, relation to serum calcium and studies in patients with medullary carcinomaN Engl J Med, 283
N. Simpson, K. Kidd, P. Goodfellow, H. McDermid, S. Myers, J. Kidd, C. Jackson, A. Duncan, L. Farrer, K. Brasch, C. Castiglione, M. Genel, J. Gertner, C. Greenberg, J. Gusella, J. Holden, B. White (1987)
Assignment of multiple endocrine neoplasia type 2A to chromosome 10 by linkageNature, 328
H. Ahlman, L. Tisell (1987)
The use of a long-acting somatostatin analogue in the treatment of advanced endocrine malignancies with gastrointestinal symptoms.Scandinavian journal of gastroenterology, 22 8
Clark OH (1985)
Endocrine Surgery of the Thyroid and Parathyroid Glands
J. Farndon, G. Leightt, W. Dilley, S. Baylin, R. Smallridge, T. Harrison, S. Wells (1986)
Familial medullary thyroid carcinoma without associated endocrinopathies: A distinct clinical entityBritish Journal of Surgery, 73
Hollander CF Boorman GA (1976)
Animal model: medullary carcinoma of the thyroid in the ratAm J Pathol, 83
S. Petursson (1988)
Metastatic medullary thyroid carcinoma: Complete response to combination chemotherapy with dacarbazine and 5‐fluorouracilCancer, 62
B. Busnardo, M. Girelli, N. Simioni, D. Nacamulli, Elisabetta Busetto (1984)
Nonparallel patterns of calcitonin and carcinoembryonic antigen levels in the follow‐up of medullary thyroid carcinomaCancer, 53
J. Hazard, W. Hawk, G. Crile (1959)
Medullary (solid) carcinoma of the thyroid; a clinicopathologic entity.The Journal of clinical endocrinology and metabolism, 19 1
L. Brunt, S. Wells (1987)
Advances in the diagnosis and treatment of medullary thyroid carcinoma.The Surgical clinics of North America, 67 2
J. Fletcher (1970)
Medullary (solid) carcinoma of the thyroid gland. A review of 249 cases.Archives of surgery, 100 3
N. Samaan, P. Schultz, R. Hickey (1988)
Medullary thyroid carcinoma: prognosis of familial versus sporadic disease and the role of radiotherapy.The Journal of clinical endocrinology and metabolism, 67 4
R. Gagel, A. Tashjian, Timothy Cummings, N. Papathanasopoulos, M. Kaplan, R. DeLellis, H. Wolfe, S. Reichlin (1988)
The clinical outcome of prospective screening for multiple endocrine neoplasia type 2a. An 18-year experience.The New England journal of medicine, 318 8
Silva OL Becker KL (1982)
The surgical implications of hypercalcitoninemiaSurg Gynecol Obstet, 154
D. Sponenberg, K. Mcentee (1983)
Pheochromocytomas and Ultimobranchial (C-cell) Neoplasms in the Bull: Evidence of Autosomal Dominant Inheritance in the Guernsey BreedVeterinary Pathology, 20
A. Tashjian, Barbara Howland, K. Melvin, C. Hill (1970)
Immunoassay of human calcitonin.The New England journal of medicine, 283 17
L. Tisell, G. Hansson, S. Jansson, H. Salander (1986)
Reoperation in the treatment of asymptomatic metastasizing medullary thyroid carcinoma.Surgery, 99 1
Tallroth E Bäckdahl M (1985)
Prognostic value of nuclear DNA content in medullary thyroid carcinomaWorld J Surg, 9
S. Wells, S. Baylin, D. Gann, Ruth Farrell, W. Dilley, Sandra Preissig, W. Linehan, C. Cooper (1978)
Medullary Thyroid Carcinoma: Relationship of Method of Diagnosis to Pathologic StagingAnnals of Surgery, 188
Ladurner D Riccabona G (1986)
When is medullary thyroid carcinoma'medullary thyroid carcinoma'?World J Surg, 10
Charles Jackson, Charles Jackson, Charles Jackson, G. Talpos, G. Talpos, G. Talpos, Angelos Kambouris, Angelos Kambouris, Angelos Kambouris, J. Yott, J. Yott, J. Yott, A. Tashjian, A. Tashjian, A. Tashjian, Melvin Block, Melvin Block, Melvin Block (1983)
The clinical course after definitive operation for medullary thyroid carcinoma.Surgery, 94 6
H. Vasen, A. Kruseman, H. Berkel, E. Beukers, C. Delprat, R. Doorn, R. Geerdink, H. Haak, W. Hackeng, H. Koppeschaar (1987)
Multiple endocrine neoplasia syndrome type 2: the value of screening and central registration. A study of 15 kindreds in The Netherlands.The American journal of medicine, 83 5
B. Gorman, J. Charboneau, E James, C. Reading, L Wold, C Grant, H. Gharib, I. Hay (1987)
Medullary thyroid carcinoma: role of high-resolution US.Radiology, 162 1 Pt 1
M. Saad, J. Guido, N. Samaan (1979)
Radioactive iodine in the treatment of medullary carcinoma of the thyroid.The Journal of clinical endocrinology and metabolism, 57 1
Fletcher JR (1970)
Medullary (solid) carcinoma of the thyroid glandArch Surg, 100
Russ Cf, Van Ja, Sizemore Gw, A. Edis, W. Taylor, W. Remine, Carney Ja (1983)
The Surgical Management of Medullary Thyroid CarcinomaAnnals of Surgery, 197
J. Norton, J. Doppman, M. Brennan (1980)
Localization and resection of clinically inapparent medullary carcinoma of the thyroid.Surgery, 87 6
Scott Lippman, Geoffrey Mendelsohn, Donald Trump, Samuel Wells, S. Baylin (1982)
The prognostic and biological significance of cellular heterogeneity in medullary thyroid carcinoma: a study of calcitonin, L-dopa decarboxylase, and histaminase.The Journal of clinical endocrinology and metabolism, 54 2
G. Boorman, C. Hollander (1976)
Animal model of human disease: medullary carcinoma of the thyroid.The American journal of pathology, 83 1
M. Saad, N. Ordóñez, Rashid Rk, J. Guido, Hill Cs, R. Hickey, N. Samaan (1984)
Medullary Carcinoma of the Thyroid: A STUDY OF THE CLINICAL FEATURES AND PROGNOSTIC FACTORS IN 161 PATIENTSMedicine, 63
W. Simpson, J. Palmer, I. Rosen, R. Mustard (1982)
Management of medullary carcinoma of the thyroid.American journal of surgery, 144 4
Abstract • Forty patients with medullary thyroid carcinoma and 3 patients with C-cell hyperplasia were studied. Seventeen (40%) cases were sporadic and 26 (60%) were hereditary. Eight patients had type Ila multiple endocrine neoplasia, 7 patients had type IIb multiple endocrine neoplasia, and 11 patients had familial nonmultiple endocrine neoplasia medullary thyroid carcinoma. Mean follow-up was 6.3 years, with actuarial survival of 88% and 78% at 5 and 10 years (22 and 13 patients), respectively. Seven patients died 1.5 to 10 years after the initial operation; all had advanced disease at presentation (6 with distant, 1 with lymph node metastasis). No deaths occurred in patients with familial nonmultiple endocrine neoplasia medullary thyroid carcinoma, C-cell hyperplasia, or medullary thyroid carcinoma limited to the thyroid gland. Nineteen (68%) of 28 patients diagnosed without screening had regional or distant metastases, whereas only 6 (40%) of 15 patients diagnosed by screening had metastases. Twenty-six patients treated initially with total thyroidectomy and central neck clearance required an average of one reoperation, whereas those with lesser initial procedures required an average of two reoperations. We concluded that (1) familial nonmultiple endocrine neoplasia medullary thyroid carcinoma, early medullary thyroid carcinoma or C-cell hyperplasia, and asymptomatic patients have a good prognosis; (2) screening for medullary thyroid carcinoma by measuring serum calcitonin levels results in earlier diagnosis; and (3) total thyroidectomy and central neck clearance is the procedure of choice for medullary thyroid carcinoma. (Arch Surg. 1989;124:1206-1210) References 1. Fletcher JR. Medullary (solid) carcinoma of the thyroid gland . Arch Surg . 1970;100:257-262.Crossref 2. Clark OH. Medullary thyroid carcinoma . In: Endocrine Surgery of the Thyroid and Parathyroid Glands . St Louis, Mo: CV Mosby Co; 1985:91-103 3. Brunt LM, Wells SA. Advances in the diagnosis and treatment of medullary thyroid carcinoma . Surg Clin North Am . 1987;67:263-279. 4. Hazard JB, Hawk WA, Crile D. Medullary (solid) carcinoma of the thyroid: a clinicopathologic entity . J Clin Endocrinol Metab . 1959;19:152-161.Crossref 5. Farndon JR, Light GS, Dilley WG, et al. Familial medullary thyroid carcinoma without associated endocrinopathies: a distinct clinical entity . Br J Surg . 1986;73:278-281.Crossref 6. Tashjian AH Jr, Howland BG, Melvin KEW, Hill CS Jr. Immunoassay of human calcitonin: clinical measurement, relation to serum calcium and studies in patients with medullary carcinoma . N Engl J Med . 1970;283:890-895Crossref 7. Becker KL, Silva OL, Snider RH, Moore CF, Geelhoed GW. The surgical implications of hypercalcitoninemia . Surg Gynecol Obstet . 1982;154:897-908 8. Wells SA, Baylin SB, Gann DS, et al. Medullary thyroid carcinoma: relationship of method of diagnosis to pathologic staging . Ann Surg . 1978;188:377-383.Crossref 9. Gagel RF, Tashjian AH Jr, Cummings T, et al. The clinical outcome of prospective screening for multiple endocrine neoplasia type 2a: an 18-year experience . N Engl J Med . 1988;318:478-484.Crossref 10. Vasen HF, Nieuwenhuijzen-Kruseman AC, Berkel H, et al. Multiple endocrine neoplasia syndrome type 2: the value of screening and central registration: a study of 15 kindreds in the Netherlands . Am J Med . 1987;83:847-852.Crossref 11. Saad MF, Ordonez NG, Rashid RK, et al. Medullary carcinoma of the thyroid: a study of the clinical features and prognostic factors in 161 patients . Medicine . 1984;63:319-342.Crossref 12. Russell CF, Van Heerden JA, Sizemore GW, et al. The surgical management of medullary thyroid carcinoma . Ann Surg . 1983;197:42-48. 13. Simpson WJ, Palmer JA, Rosen IB, Mustard RA. Management of medullary carcinoma of the thyroid . Am J Surg . 1982;144:420-422.Crossref 14. Jackson CE, Talpos GB, Kambouris A, Yott JB, Tashjian AH Jr, Block MA. The clinical course after definitive operation for medullary thyroid carcinoma . Surgery . 1983;94:995-1001. 15. Tisell LE, Hansson G, Jansson S, Salander H. Reoperation in the treatment of asymptomatic metastasizing medullary thyroid carcinoma . Surgery . 1986;99:60-66. 16. Saad MF, Guido JJ, Samman NA. Radioactive iodine in the treatment of medullary carcinoma of the thyroid . J Clin Endocinol Metab . 1983;57:124-128.Crossref 17. Riccabona G, Ladurner D, Schmid K. When is medullary thyroid carcinoma'medullary thyroid carcinoma'? World J Surg . 1986;10:745-752.Crossref 18. Samaan NA, Schultz PN, Hickey RC. Medullary thyroid carcinoma: prognosis of familial versus sporadic disease and the role of radiotherapy . J Clin Endocrinol Metab . 1988;67:801-805.Crossref 19. Petursson SR. Metastatic medullary thyroid carcinoma: complete response to combination chemotherapy with dacarbazine and 5-fluorouracil . Cancer . 1988;62:1899-1903.Crossref 20. Ahlman H, Tisell LE. The use of a long-acting somatostatin analogue in the treatment of advanced endocrine malignancies with gastrointestinal symptoms . Scand J Gastroenterol . 1987;22:938-942.Crossref 21. Gorman B, Charboneau JW, James EM, et al. Medullary thyroid carcinoma: role of high-resolution US . Radiology . 1987;162:147-150.Crossref 22. Norton JA, Doppman JL, Brennan MF. Localization and resection ofclinically inapparent medullary carcinoma of the thyroid . Surgery . 1980;87:616-622. 23. Busnardo B, Girelli ME, Simioni N, Nacamulli D, Busetto E. Nonparallel patterns of calcitonin and carcinoembryonic antigen levels in the follow-up of medullary thyroid carcinoma . Cancer . 1984;53:278-285.Crossref 24. Simpson NE, Kidd KK, Goodfellow PJ, et al. Assignment of multipleendocrine neoplasia type 2A to chromosome 10 by linkage . Nature . 1987;328:528-530.Crossref 25. Boorman GA, Hollander CF. Animal model: medullary carcinoma of the thyroid in the rat . Am J Pathol . 1976;83:237-240. 26. Sponenberg DP, McEntee K. Pheochromocytomas and ultimobrachial (C-cell) neoplasm in the bull: evidence of autosomal dominant inheritance in the Guernsey breed . Vet Pathol . 1983;20:396-400.Crossref 27. Bäckdahl M, Tallroth E, Auer G, et al. Prognostic value of nuclear DNA content in medullary thyroid carcinoma . World J Surg . 1985;9:980-987.Crossref 28. Lippman SM, Mendelsohn G, Trump DL, Wells SA Jr, Baylin SB. The prognostic and biological significance of cellular heterogeneity in medullary thyroid carcinoma: a study of calcitonin, L-dopa, dicarboxylase, and histaminase . J Clin Endocrinol Metab . 1982;54:233-240.Crossref
Archives of Surgery – American Medical Association
Published: Oct 1, 1989
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