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Effects of Prostaglandins on Motility of Gallbladders Removed From Patients With Gallstones

Effects of Prostaglandins on Motility of Gallbladders Removed From Patients With Gallstones Abstract • Prostaglandins (PGs) affect smooth-muscle contractility and are also involved in the inflammatory reaction. They may therefore affect gallbladder motility in cholecystitis. The contractile effects of PGs were recorded in organ baths on strips from 63 fresh, surgically removed human gallbladders. Spontaneous rhythmic contractions were reduced or abolished by indomethacin, which inhibits endogenous PG synthesis. In strips with chronic cholecystitis, concentration-dependent contractions were produced by PGF2, PGB2 and PGD2; the responses to PGE1 and PGE2 were sometimes variable but there were concentration-dependent contractions after treatment of the strips with indomethacin. The majority of strips with acute cholecystitis responded poorly to PGs even after pretreatment with indomethacin. We concluded from this preliminary study that PGs could affect gallbladder motility and that indomethacin probably reduces the endogenous production of PGs in the gallbladder. (Arch Surg 1984;119:709-712) References 1. Von Euler US: On the specific vaso-dilating and plain muscle stimulating substances from accessory genital glands in man and certain animals (prostaglandin and vesiglandin) . J Physiol 1937;88:213-234. 2. Moncada S, Ferreira SH, Vane JR: PGs, aspirin-like drugs and the edema of inflammation . Nature 1973;246:217-219.Crossref 3. Sharon P, Ligumsky M, Rachmilewitz D, et al: Role of prostaglandins in ulcerative colitis: Enhanced production during active disease and inhibition by sulfasalazine . Gastroenterology 1978;75:638-640. 4. Shafran I, Maurer W, Thomas FB: Prostaglandins and Crohn's disease . N Engl J Med 1977;296:694. 5. Wood JR, Stamford IF: Prostaglandins in chronic cholecystitis . Prostaglandins 1977;13:97-107.Crossref 6. Wood JR, Saverymuttu SH, Ashbrooke AB, et al: Effects of various prostanoids on gallbladder muscle . Adv Prostaglandin Thromboxane Leukotriene Res 1980;8:1569-1571. 7. Mroczka J, Baer HP, Scott GW: Effects of prostaglandins in isolated dog gallbladder and cystic duct , in Weinbeck M (ed): Motility of the Digestive Tract . New York, Raven Press, 1982, pp 421-426. 8. Thornell E, Jansson R, Svanvik J: Indomethacin intravenously: A new way for effective relief of biliary pain: A double-blind study in man . Surgery 1981;90:468-472. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Effects of Prostaglandins on Motility of Gallbladders Removed From Patients With Gallstones

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References (10)

Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1984.01390180071012
Publisher site
See Article on Publisher Site

Abstract

Abstract • Prostaglandins (PGs) affect smooth-muscle contractility and are also involved in the inflammatory reaction. They may therefore affect gallbladder motility in cholecystitis. The contractile effects of PGs were recorded in organ baths on strips from 63 fresh, surgically removed human gallbladders. Spontaneous rhythmic contractions were reduced or abolished by indomethacin, which inhibits endogenous PG synthesis. In strips with chronic cholecystitis, concentration-dependent contractions were produced by PGF2, PGB2 and PGD2; the responses to PGE1 and PGE2 were sometimes variable but there were concentration-dependent contractions after treatment of the strips with indomethacin. The majority of strips with acute cholecystitis responded poorly to PGs even after pretreatment with indomethacin. We concluded from this preliminary study that PGs could affect gallbladder motility and that indomethacin probably reduces the endogenous production of PGs in the gallbladder. (Arch Surg 1984;119:709-712) References 1. Von Euler US: On the specific vaso-dilating and plain muscle stimulating substances from accessory genital glands in man and certain animals (prostaglandin and vesiglandin) . J Physiol 1937;88:213-234. 2. Moncada S, Ferreira SH, Vane JR: PGs, aspirin-like drugs and the edema of inflammation . Nature 1973;246:217-219.Crossref 3. Sharon P, Ligumsky M, Rachmilewitz D, et al: Role of prostaglandins in ulcerative colitis: Enhanced production during active disease and inhibition by sulfasalazine . Gastroenterology 1978;75:638-640. 4. Shafran I, Maurer W, Thomas FB: Prostaglandins and Crohn's disease . N Engl J Med 1977;296:694. 5. Wood JR, Stamford IF: Prostaglandins in chronic cholecystitis . Prostaglandins 1977;13:97-107.Crossref 6. Wood JR, Saverymuttu SH, Ashbrooke AB, et al: Effects of various prostanoids on gallbladder muscle . Adv Prostaglandin Thromboxane Leukotriene Res 1980;8:1569-1571. 7. Mroczka J, Baer HP, Scott GW: Effects of prostaglandins in isolated dog gallbladder and cystic duct , in Weinbeck M (ed): Motility of the Digestive Tract . New York, Raven Press, 1982, pp 421-426. 8. Thornell E, Jansson R, Svanvik J: Indomethacin intravenously: A new way for effective relief of biliary pain: A double-blind study in man . Surgery 1981;90:468-472.

Journal

Archives of Surgery – American Medical Association

Published: Jun 1, 1984

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