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Effect of Abdominal Operations on Survival After Septic Challenge in Normal Rats

Effect of Abdominal Operations on Survival After Septic Challenge in Normal Rats Abstract • We evaluated the effect of 60% small-bowel enterectomy that removed 75% of Peyer's patches, and the effects of lesser abdominal operations, on the survival of rats following inducement of peritonitis. We divided 286 female Fischer rats weighing 140 to 200 g into four experimental and two control groups. Following enterectomy, rats recovered for ten to 14 days before peritonitis was induced by intraperitoneal injection of 0.7 mL/100 g of body weight of a solution of 4% hemoglobin and Escherichia coli (109/mL). At 48 hours after enterectomy, the survival rate was better than that in rats not operated on or anesthetized. Survival rates for rats having lesser intra-abdominal operations were significantly greater after peritonitis than the rates for controls, but were similar to rates for rats having enterectomies. Our results suggest that intra-abdominal operation of minimal or large magnitude is associated with improved survival from hemoglobin—E coli adjuvant peritonitis. (Arch Surg 1984;119:71-74) References 1. Petersen SR, Kudsk KA, Carpenter G, et al: Malnutrition and immunocompetence: Increased mortality following an infectious challenge during hyperalimentation . J Trauma 1981;21:528-533.Crossref 2. Kudsk KA, Carpenter G, Sheldon GF: Effect of route of nutrient administration on survival with hemoglobin—E coli adjuvant peritonitis in normal rats . Surg Forum 1981;22:102-104. 3. Stone JM, Carpenter G, Sheldon GF: Effect of femur fracture on survival after septic challenge in normal rats . Surg Forum 1981;22:83-84. 4. Williams DL, Browder IW, DiLuzio NR: Immunotherapeutic modification of E coli—induced experimental peritonitis and bacteremia by glucan . Surgery 1983;93:448-454. 5. Joyce LD, Hau T, Hoffman R, et al: Evaluation of the mechanism of zymosan induced resistance to experimental peritonitis . Surgery 1978;83: 717-725. 6. Galland RB, Heine KJ, Polk HC Jr: Nonspecific stimulation of host defenses against bacterial challenge in immunosuppressed mice . Arch Surg 1983;118:333-337.Crossref 7. Clark RA, Leung DYK, Hohn D: Role of macrophages in wound healing . Surg Forum 1976;27:16-18. 8. Richards PS, Saba TM: Fibronectin levels during intraperitoneal inflammation . Infect Immun 1983;39:1411-1418. 9. Van Furth R, Diesselhoff-Den-Dulk MMC, Mattie H: Quantitative study on the production and kinetics of mononuclear phagocytes during an acute inflammatory reaction . J Exp Med 1973;138:1314-1330.Crossref 10. Werb Z: Phagocytic cells: Chemotaxis and effector functions of macrophages and granulocytes , in Stites DP (ed): Basic and Clinical Immunology . Los Altos, Calif, Lange Medical Publications, 1982, pp 109-123. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Effect of Abdominal Operations on Survival After Septic Challenge in Normal Rats

Archives of Surgery , Volume 119 (1) – Jan 1, 1984

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1984.01390130055010
Publisher site
See Article on Publisher Site

Abstract

Abstract • We evaluated the effect of 60% small-bowel enterectomy that removed 75% of Peyer's patches, and the effects of lesser abdominal operations, on the survival of rats following inducement of peritonitis. We divided 286 female Fischer rats weighing 140 to 200 g into four experimental and two control groups. Following enterectomy, rats recovered for ten to 14 days before peritonitis was induced by intraperitoneal injection of 0.7 mL/100 g of body weight of a solution of 4% hemoglobin and Escherichia coli (109/mL). At 48 hours after enterectomy, the survival rate was better than that in rats not operated on or anesthetized. Survival rates for rats having lesser intra-abdominal operations were significantly greater after peritonitis than the rates for controls, but were similar to rates for rats having enterectomies. Our results suggest that intra-abdominal operation of minimal or large magnitude is associated with improved survival from hemoglobin—E coli adjuvant peritonitis. (Arch Surg 1984;119:71-74) References 1. Petersen SR, Kudsk KA, Carpenter G, et al: Malnutrition and immunocompetence: Increased mortality following an infectious challenge during hyperalimentation . J Trauma 1981;21:528-533.Crossref 2. Kudsk KA, Carpenter G, Sheldon GF: Effect of route of nutrient administration on survival with hemoglobin—E coli adjuvant peritonitis in normal rats . Surg Forum 1981;22:102-104. 3. Stone JM, Carpenter G, Sheldon GF: Effect of femur fracture on survival after septic challenge in normal rats . Surg Forum 1981;22:83-84. 4. Williams DL, Browder IW, DiLuzio NR: Immunotherapeutic modification of E coli—induced experimental peritonitis and bacteremia by glucan . Surgery 1983;93:448-454. 5. Joyce LD, Hau T, Hoffman R, et al: Evaluation of the mechanism of zymosan induced resistance to experimental peritonitis . Surgery 1978;83: 717-725. 6. Galland RB, Heine KJ, Polk HC Jr: Nonspecific stimulation of host defenses against bacterial challenge in immunosuppressed mice . Arch Surg 1983;118:333-337.Crossref 7. Clark RA, Leung DYK, Hohn D: Role of macrophages in wound healing . Surg Forum 1976;27:16-18. 8. Richards PS, Saba TM: Fibronectin levels during intraperitoneal inflammation . Infect Immun 1983;39:1411-1418. 9. Van Furth R, Diesselhoff-Den-Dulk MMC, Mattie H: Quantitative study on the production and kinetics of mononuclear phagocytes during an acute inflammatory reaction . J Exp Med 1973;138:1314-1330.Crossref 10. Werb Z: Phagocytic cells: Chemotaxis and effector functions of macrophages and granulocytes , in Stites DP (ed): Basic and Clinical Immunology . Los Altos, Calif, Lange Medical Publications, 1982, pp 109-123.

Journal

Archives of SurgeryAmerican Medical Association

Published: Jan 1, 1984

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