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Comparative Tissue Reactivity to Topical Hemostatic Agents in the Periureteral Area

Comparative Tissue Reactivity to Topical Hemostatic Agents in the Periureteral Area Abstract • Application of the topical hemostatic agents microfibrillar collagen hemostat (Avitene), oxidized cellulose (Surgicel), and absorbable gelatin sponge (Gelfoam) to the periureteral regions in dogs did not incite an adverse inflammatory or fibrotic reaction when used in standard, recommended fashion. No instances of ureteral obstruction resulted from such application. The addition of a small amount of sterile urine in the same area with the topical agent did not influence the degree of reaction. We concluded that these useful hemostatic agents, when used properly, are absorbed with only slight or no residual tissue reaction. The adverse tissue reaction occasionally reported probably can be ascribed to either improper use of the hemostatic agent, other concomitant noxious influences such as infection, or admixture with abnormal collections of body fluids. (Arch Surg 1983;118:1375-1377) References 1. Sanfilippo JS, Barrows GH, Yussman MA: Comparison of Avitene, topical thrombin, and Gelfoam as sole hemostatic agent in tuboplasties . Fertil Steril 1980;33:311-316. 2. Raftery AT: Absorbable haemostatic materials and intraperitoneal adhesion formation . Br J Surg 1980;6:57-58.Crossref 3. Larsson B, Nisell H, Granberg I: Surgicel-an absorbable hemostatic material: In prevention of peritoneal adhesions in rats . Acta Chir Scand 1978;144:375-378. 4. Chung AF, Menon J, Dillon TF: Acute postoperative retroperitoneal fibrosis and ureteral obstruction secondary to the use of Avitene . Am J Obstet Gynecol 1978;132:908-909. 5. Park SA, Giannattasio C, Tancer ML: Foreign body reaction to the intraperitonal use of Avitene . Obstet Gynecol 1981;58:664-667. 6. Ohlsen L: Retroperitoneal fibrosis due to leakage of urine: A contribution to the etiology of idiopathic retroperitoneal fibrosis . Acta Soc Med Upsal 1965;70:231-240. 7. Mitchinson MJ, Bird DR: Urinary leakage and retroperitoneal fibrosis . J Urol 1971;105:56-58. 8. Cerny JC, Scott T: Non-idiopathic retroperitoneal fibrosis . J Urol 1971;105:49-55. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Comparative Tissue Reactivity to Topical Hemostatic Agents in the Periureteral Area

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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1983.01390120005003
Publisher site
See Article on Publisher Site

Abstract

Abstract • Application of the topical hemostatic agents microfibrillar collagen hemostat (Avitene), oxidized cellulose (Surgicel), and absorbable gelatin sponge (Gelfoam) to the periureteral regions in dogs did not incite an adverse inflammatory or fibrotic reaction when used in standard, recommended fashion. No instances of ureteral obstruction resulted from such application. The addition of a small amount of sterile urine in the same area with the topical agent did not influence the degree of reaction. We concluded that these useful hemostatic agents, when used properly, are absorbed with only slight or no residual tissue reaction. The adverse tissue reaction occasionally reported probably can be ascribed to either improper use of the hemostatic agent, other concomitant noxious influences such as infection, or admixture with abnormal collections of body fluids. (Arch Surg 1983;118:1375-1377) References 1. Sanfilippo JS, Barrows GH, Yussman MA: Comparison of Avitene, topical thrombin, and Gelfoam as sole hemostatic agent in tuboplasties . Fertil Steril 1980;33:311-316. 2. Raftery AT: Absorbable haemostatic materials and intraperitoneal adhesion formation . Br J Surg 1980;6:57-58.Crossref 3. Larsson B, Nisell H, Granberg I: Surgicel-an absorbable hemostatic material: In prevention of peritoneal adhesions in rats . Acta Chir Scand 1978;144:375-378. 4. Chung AF, Menon J, Dillon TF: Acute postoperative retroperitoneal fibrosis and ureteral obstruction secondary to the use of Avitene . Am J Obstet Gynecol 1978;132:908-909. 5. Park SA, Giannattasio C, Tancer ML: Foreign body reaction to the intraperitonal use of Avitene . Obstet Gynecol 1981;58:664-667. 6. Ohlsen L: Retroperitoneal fibrosis due to leakage of urine: A contribution to the etiology of idiopathic retroperitoneal fibrosis . Acta Soc Med Upsal 1965;70:231-240. 7. Mitchinson MJ, Bird DR: Urinary leakage and retroperitoneal fibrosis . J Urol 1971;105:56-58. 8. Cerny JC, Scott T: Non-idiopathic retroperitoneal fibrosis . J Urol 1971;105:49-55.

Journal

Archives of SurgeryAmerican Medical Association

Published: Dec 1, 1983

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