Access the full text.
Sign up today, get DeepDyve free for 14 days.
B. Macpherson, C. Pfeiffer (1978)
Experimental production of diffuse colitis in rats.Digestion, 17 2
Livstone EM Michaud JT (1976)
Antoradiographic measurement of early proliferative changes in the right colon after small bowel resectionGastroenterology, 70
M. Tilson, M. Buck, E. Livstone, D. Sheahan (1977)
Increased invasiveness of colonic carcinomas induced by dimethylhydrazine in rats with partial small-bowel resection.Surgical forum, 28
J. Oscarson, H. Veen, J. Ross, R. Malt (1979)
Ileal resection potentiates 1,2-dimethylhydrazine-induced colonic carcinogenesis.Annals of surgery, 189 4
K. Pozharisski (1975)
The significance of nonspecific injury for colon carcinogenesis in rats.Cancer research, 35 12
R. Williamson, F. Bauer, J. Oscarson, J. Ross, R. Malt (1978)
Promotion of azoxymethane-induced colonic neoplasia by resection of the proximal small bowel.Cancer research, 38 10
T. Giblin, K. Pickrell, W. Pitts, D. Armstrong (1965)
Malignant Degeneration in Burn Scars: Marjolin's UlcerAnnals of Surgery, 162
Nirmal Mann, S. Mann, E. Cheung (1980)
Fiberoptic colonoscopic study of experimental chemical colitis.Gastrointestinal endoscopy, 26 2
B. Gottfried, N. Molomut, J. Patti (1961)
Effect of repeated surgical trauma on chemical carcinogenesis.Cancer research, 21
Tilson, Michaud Jt, Livstone Em (1976)
Early proliferative activity in the left colon of the rat after partial small--bowel resection.Surgical forum, 27 62
Druckrey H (1970)
Carcinoma of the Colon and Antecedent Epithelium
Nolton Blgelow (1953)
Carcinoma of the esophagus developing at the site of lye strictureCancer, 6
Cruickshank Ah, Mcconnell Em, Miller Dg (1963)
Malignancy in scars, chronic ulcers, and sinusesJournal of Clinical Pathology, 16
R. Campbell, D. Singh, N. Nigro (1975)
Importance of the fecal stream on the induction of colon tumors by azoxymethane in rats.Cancer research, 35 5
E. Fiala, C. Kulakis, G. Bobotas, J. Weisburger (1976)
Detection and estimation of azomethane in expired air of 1,2-dimethylhydrazine-treated rats.Journal of the National Cancer Institute, 56 6
Abstract • To study the effect of acetic acid colitis on 1,2-dimethylhydrazine-induced colon tumorigenesis, Fischer 344 male rats, 10 weeks of age, were divided into three groups: one receiving 5% acetic acid enema (subgroup 1a); one receiving 10% acetic acid enema (subgroup 1b); and one not receiving acetic acid enema (group 2). Colitis developed in rats in groups 1a and 1b, resulting in early death in some cases. Rats of all three groups received the same subcutaneous dose of dimethylhydrazine given once a week for 20 weeks starting at 11 weeks of age; they were killed at 31 weeks after the first dimethylhydrazine injection. The percentage of animals having tumors in the large bowel was greatest in subgroup 1b and least in group 2. The mean number of largebowel tumors per animal in which large-bowel tumors had developed was determined in each group. The mean number of subgroup 1b was greater than that of group 2 and also greater than that of groups 1a and 2 combined. The results of the study suggest that colonic mucosal injury may render the colonic epithelium susceptible to tumor induction by carcinogens in the fecal stream. (Arch Surg 1982;117:1304-1307) References 1. Mann NS, Mann SK, Cheung EC: Fiberoptic colonscopy study of experimental chemical colitis . Gastrointest Endosc 1980;26:38-40.Crossref 2. Bigelow NH: Carcinoma of the esophagus developing at the site of lye stricture . Cancer 1953;6:1159-1164.Crossref 3. Cruickshank AH, McConnell EM, Miller DG: Malignancy in scars, chronic ulcers, and sinuses . J Clin Pathol 1963;16:573-580.Crossref 4. Giblin T, Pickrell K, Pitts W, et al: Malignant degeneration in burn scars: Marjolin's ulcer . Ann Surg 1965;162:291-297.Crossref 5. Gottfried B, Molomut N, Patti J: Effect of repeated surgical trauma on chemical carcinogenesis . Cancer Res 1961;21:658-660. 6. Campbell RL, Singh DV, Nigro ND: Importance of the fecal stream on the induction of colon tumors by azoxymethane in rats . Cancer Res 1975;35:1369-1371. 7. Druckrey H: Production of colonic carcinomas by 1,2-dialykylhydrazines and azoxyalkanes , in Burdette WJ (ed): Carcinoma of the Colon and Antecedent Epithelium . Springfield, Ill, Charles C Thomas Publisher, 1970, pp 267-279. 8. Fiala ES, Kulakis C, Bobotas G, et al: Detection and estimation of azomethane in expired air of 1,2-dimethylhydrazine treated rats . JNCI 1976;56:1271-1273. 9. MacPherson BR, Pfeiffer CJ: Experimental production of diffuse colitis in rats . Digestion 1978;17:135-150.Crossref 10. Oscarson JEA, Veen HF, Ross JS, et al: Ileal resection potentiates 1,2-dimethylhydrazine-induced colonic carcinogenesis . Ann Surg 1979; 189:503-508. 11. Tilson MD, Buck M, Livstone EM, et al: Increased invasiveness of colonic carcinomas induced by dimethylhydrazine in rats with partial small bowel resection . Surg Forum 1977;28:139-140. 12. Williamson RCN, Bauer FL, Oscarson JEA, et al: Promotion of azoxymethane-induced colonic neoplasia by resection of the proximal small bowel . Cancer Res 1978;38:3212-3217. 13. Michaud JT, Livstone EM, Tilson MD: Antoradiographic measurement of early proliferative changes in the right colon after small bowel resection , abstracted. Gastroenterology 1976;70:A-62/920. 14. Tilson MD, Michaud JT, Livstone EM: Early proliferative activity in the left colon of the rat after partial small bowel resection . Surg Forum 1976;27:445-446. 15. Pozharisski KM: The significance of non-specific injury for colon carcinogenesis in rats . Cancer Res 1975;35:3824-3830.
Archives of Surgery – American Medical Association
Published: Oct 1, 1982
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.