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Early Proliferative Activity: Its Occurrence in the Crypts of Small Bowel and Colon After Partial Small-Bowel Resection

Early Proliferative Activity: Its Occurrence in the Crypts of Small Bowel and Colon After Partial... Abstract • Crypt population kinetics in both small bowel and colon were determined in the early postoperative period in the rat after either sham resection or resection of 50% of the midportion of the small bowel. A proliferative response was evident in the colon within 24 hours. This response of the labeling index was statistically significant in the left colon by comparison with the sham-resected animals, whereas in the right colon it was significant by comparison not only with the sham-resected but also with the intact animals. A proliferative response was documented in the remnants of the small bowel on the third postoperative day by comparison with those of the sham-resected animals. These findings indicate that adaptive hyperplasia begins very promptly in the intestinal remnants after partial resection. (Arch Surg 115:1481-1485, 1980) References 1. Hanson WR, Osborne JW, Sharp JG: Compensation by the residual intestine after intestinal resection in the rat: I. Influence of amount of tissue removed: II. Influence of postoperative time interval . Gastroenterology 73:692-705, 1977. 2. Obertop H, Nundy S, Malamud D, et al: Onset of cell proliferation in the shortened gut: Rapid hyperplasia after jejunal resection . Gastroenterology 72:267-270, 1977. 3. Nundy S, Malamud D, Obertop H, et al: Onset of cell proliferation in the shortened gut: Colonic hyperplasia after ileal resection . Gastroenterology 72:263-266, 1977. 4. Dowling RH, Booth CC: Structural and functional changes following small intestinal resection in the rat . Clin Sci 32:139-149, 1967. 5. Hanson WR, Rijke RPC, Plaisier HM, et al: The effect of intestinal resection on Thirty-Vella fistulae of jejunal and ileal origin in the rat: Evidence for a systemic control mechanism of cell renewal . Cell Tissue Kinet 10:543-555, 1977. 6. Levine GH, Deren JJ: Dietary and nondietary factors mediating hyperplasia of residual gut mucosa after small bowel resection in the rat . Clin Res 22:363A, 1974. 7. Tilson MD, Wright HK: Adaptation of functioning and bypassed segments of ileum during compensatory hypertrophy of the gut . Surgery 67:687-693, 1970. 8. Tilson MD, Wright HK: Adaptational changes in the ileum following jejunectomy , in Goss RJ (ed): Regulation of Organ and Tissue Growth . New York, Academic Press Inc, 1972, pp 257-277. 9. Tilson MD, Livstone EM: Radioautography of heterotopic autografts of ileal mucosa in rats after partial enterectomy . Surg Forum 26:393-394, 1975. 10. Williamson RCN, Buchholtz TW, Malt RA: Humoral stimulation of cell proliferation in small bowel after transection and resection in rats . Gastroenterology 75:249-254, 1978. 11. Laplace JP: Effet humoral de la resection intestinals chez des procs en circulation sanguine croissee chronique . Biol Gastroenterol 6:359, 1973. 12. Buchholtz TW, Malamud D, Ross JS, et al: Onset of cell proliferation in the shortened gut; growth after subtotal colectomy . Surgery 80:601-607, 1976. 13. Masesa PC, Forrester JM: Consequences of partial and subtotal colectomy in the rat . Gut 18:37-44, 1977.Crossref 14. Wright HK, Tilson MD: Changes in structure and function of the small intestine after colectomy , in Dowling RH, Riecken FO (eds): Intestinal Adapation . New York, FK Schattauer Verlag, 1974, p 99-106. 15. Winborn WB, Seelig LL, Nakayama H, et al: Hyperplasia of the gastric glands after small bowel resection in the rat . Gastroenterology 66:384-395, 1974. 16. Williamson RCN: Hyperplasia and neoplasia of the intestinal tract . Ann R Coll Surg Engl 61:341-348, 1979. 17. Oscarson JEA, Veen HF, Ross JS, et al: Ileal resection potentiates 1,2-dimethylhydrazine-induced colonic carcinogenesis . Ann Surg 189:503-508, 1979. 18. Tilson MD, Buck M, Livstone EM, et al: Increased invasiveness of colonic carcinomas induced by dimethylhydrazine in rats with partial small bowel resection . Surg Forum 28:139-140, 1977. 19. Tilson MD: Colonic carcinogenesis in the rat after partial small bowel resection and a single dose of dimethylhydrazine. Surg Forum, to be published. 20. Sachatello CR: Colon cancer and cholestyramine . N Engl J Med 301:1007, 1979. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Early Proliferative Activity: Its Occurrence in the Crypts of Small Bowel and Colon After Partial Small-Bowel Resection

Tilson, M. David; Livstone, Elliot M.
Archives of Surgery , Volume 115 (12) – Dec 1, 1980
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References (22)

Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1980.01380120049012
Publisher site
See Article on Publisher Site

Abstract

Abstract • Crypt population kinetics in both small bowel and colon were determined in the early postoperative period in the rat after either sham resection or resection of 50% of the midportion of the small bowel. A proliferative response was evident in the colon within 24 hours. This response of the labeling index was statistically significant in the left colon by comparison with the sham-resected animals, whereas in the right colon it was significant by comparison not only with the sham-resected but also with the intact animals. A proliferative response was documented in the remnants of the small bowel on the third postoperative day by comparison with those of the sham-resected animals. These findings indicate that adaptive hyperplasia begins very promptly in the intestinal remnants after partial resection. (Arch Surg 115:1481-1485, 1980) References 1. Hanson WR, Osborne JW, Sharp JG: Compensation by the residual intestine after intestinal resection in the rat: I. Influence of amount of tissue removed: II. Influence of postoperative time interval . Gastroenterology 73:692-705, 1977. 2. Obertop H, Nundy S, Malamud D, et al: Onset of cell proliferation in the shortened gut: Rapid hyperplasia after jejunal resection . Gastroenterology 72:267-270, 1977. 3. Nundy S, Malamud D, Obertop H, et al: Onset of cell proliferation in the shortened gut: Colonic hyperplasia after ileal resection . Gastroenterology 72:263-266, 1977. 4. Dowling RH, Booth CC: Structural and functional changes following small intestinal resection in the rat . Clin Sci 32:139-149, 1967. 5. Hanson WR, Rijke RPC, Plaisier HM, et al: The effect of intestinal resection on Thirty-Vella fistulae of jejunal and ileal origin in the rat: Evidence for a systemic control mechanism of cell renewal . Cell Tissue Kinet 10:543-555, 1977. 6. Levine GH, Deren JJ: Dietary and nondietary factors mediating hyperplasia of residual gut mucosa after small bowel resection in the rat . Clin Res 22:363A, 1974. 7. Tilson MD, Wright HK: Adaptation of functioning and bypassed segments of ileum during compensatory hypertrophy of the gut . Surgery 67:687-693, 1970. 8. Tilson MD, Wright HK: Adaptational changes in the ileum following jejunectomy , in Goss RJ (ed): Regulation of Organ and Tissue Growth . New York, Academic Press Inc, 1972, pp 257-277. 9. Tilson MD, Livstone EM: Radioautography of heterotopic autografts of ileal mucosa in rats after partial enterectomy . Surg Forum 26:393-394, 1975. 10. Williamson RCN, Buchholtz TW, Malt RA: Humoral stimulation of cell proliferation in small bowel after transection and resection in rats . Gastroenterology 75:249-254, 1978. 11. Laplace JP: Effet humoral de la resection intestinals chez des procs en circulation sanguine croissee chronique . Biol Gastroenterol 6:359, 1973. 12. Buchholtz TW, Malamud D, Ross JS, et al: Onset of cell proliferation in the shortened gut; growth after subtotal colectomy . Surgery 80:601-607, 1976. 13. Masesa PC, Forrester JM: Consequences of partial and subtotal colectomy in the rat . Gut 18:37-44, 1977.Crossref 14. Wright HK, Tilson MD: Changes in structure and function of the small intestine after colectomy , in Dowling RH, Riecken FO (eds): Intestinal Adapation . New York, FK Schattauer Verlag, 1974, p 99-106. 15. Winborn WB, Seelig LL, Nakayama H, et al: Hyperplasia of the gastric glands after small bowel resection in the rat . Gastroenterology 66:384-395, 1974. 16. Williamson RCN: Hyperplasia and neoplasia of the intestinal tract . Ann R Coll Surg Engl 61:341-348, 1979. 17. Oscarson JEA, Veen HF, Ross JS, et al: Ileal resection potentiates 1,2-dimethylhydrazine-induced colonic carcinogenesis . Ann Surg 189:503-508, 1979. 18. Tilson MD, Buck M, Livstone EM, et al: Increased invasiveness of colonic carcinomas induced by dimethylhydrazine in rats with partial small bowel resection . Surg Forum 28:139-140, 1977. 19. Tilson MD: Colonic carcinogenesis in the rat after partial small bowel resection and a single dose of dimethylhydrazine. Surg Forum, to be published. 20. Sachatello CR: Colon cancer and cholestyramine . N Engl J Med 301:1007, 1979.

Journal

Archives of Surgery – American Medical Association

Published: Dec 1, 1980

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