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Hazards of Heparin Therapy

Hazards of Heparin Therapy Abstract To the Editor.—In response to the recent article by Ariyan and Stansel outlining the dangers associated with delayed bleeding following heparin sodium administration in three patients with vascular anastomoses, all of the treated individuals received the same dose of heparin during bolus intravenous therapy, and aside from the Lee-White clotting time determined in the second patient, adjustments in dosage according to body weight, plasma coagulation factors, platelet function, or underlying pathologic problems were not done. Work in our laboratory over the past four years has indicated that these variables may be important in the calculation of heparin dosage.1.2 We have demonstrated the importance of platelets and platelet red blood cell interactions in the neutralization of intravenously administered heparin in the dog. In addition, unpublished data from our laboratory demonstrate the tremendous fluctuation between incoagulability and hypercoagulability of a variety of tests following bolus heparin injections in the dog. References 1. Caprini JA, Eckenhoff JB, Ramstack JM, et al: Contact activation of heparinized plasma . Thromb Res 5:379-400, 1974.Crossref 2. Zuckerman L, Ramstack JM, Vagher JP, et al: Neutralization of heparin by cellular blood elements . Thromb Res 7:149-159, 1975.Crossref 3. Gaylor JDS, Murphy JF, Caprini JA, et al: Gas transfer and thrombogenesis in an annular membrane oxygenator with active blood mixing . Trans Am Soc Artif Intern Organs 19:516-524, 1973.Crossref 4. Salzman EW, Deykin D, Shapiro RM, et al: Management of heparin therapy . N Engl J Med 292:1046-1050, 1975.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Hazards of Heparin Therapy

CAPRINI, JOSEPH A.
Archives of Surgery , Volume 111 (5) – May 1, 1976
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Hazards of Heparin Therapy

Abstract

Abstract To the Editor.—In response to the recent article by Ariyan and Stansel outlining the dangers associated with delayed bleeding following heparin sodium administration in three patients with vascular anastomoses, all of the treated individuals received the same dose of heparin during bolus intravenous therapy, and aside from the Lee-White clotting time determined in the second patient, adjustments in dosage according to body weight, plasma coagulation factors, platelet function,...
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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1976.01360230114032
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.—In response to the recent article by Ariyan and Stansel outlining the dangers associated with delayed bleeding following heparin sodium administration in three patients with vascular anastomoses, all of the treated individuals received the same dose of heparin during bolus intravenous therapy, and aside from the Lee-White clotting time determined in the second patient, adjustments in dosage according to body weight, plasma coagulation factors, platelet function, or underlying pathologic problems were not done. Work in our laboratory over the past four years has indicated that these variables may be important in the calculation of heparin dosage.1.2 We have demonstrated the importance of platelets and platelet red blood cell interactions in the neutralization of intravenously administered heparin in the dog. In addition, unpublished data from our laboratory demonstrate the tremendous fluctuation between incoagulability and hypercoagulability of a variety of tests following bolus heparin injections in the dog. References 1. Caprini JA, Eckenhoff JB, Ramstack JM, et al: Contact activation of heparinized plasma . Thromb Res 5:379-400, 1974.Crossref 2. Zuckerman L, Ramstack JM, Vagher JP, et al: Neutralization of heparin by cellular blood elements . Thromb Res 7:149-159, 1975.Crossref 3. Gaylor JDS, Murphy JF, Caprini JA, et al: Gas transfer and thrombogenesis in an annular membrane oxygenator with active blood mixing . Trans Am Soc Artif Intern Organs 19:516-524, 1973.Crossref 4. Salzman EW, Deykin D, Shapiro RM, et al: Management of heparin therapy . N Engl J Med 292:1046-1050, 1975.Crossref

Journal

Archives of Surgery – American Medical Association

Published: May 1, 1976

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