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Species Differences in Response to Renal Ischemia

Species Differences in Response to Renal Ischemia Abstract • Different species appear to tolerate different amounts of renal ischemia. It is suggested that all kidneys are equally susceptible to ischemic damage, but that the whole animal response varies between species. Mice, rats, rabbits, and pigs were subjected to bilateral nephrectomy. Large animals had relatively smaller kidneys and survived longer than smaller animals. Therefore, the larger the animal, the more time available for recovery of a kidney damaged by ischemia. This adequately explains the apparent species differences in susceptibility to renal ischemia, which are only seen when the kidney is expected to support life immediately. Simple relationships are described, relating metabolic rate, body size, and survival time with no renal function. (Arch Surg 111:582-584, 1976) References 1. Clegg JF, Kulatilake AE, Chisholm GD, et al: The significance of ischaemia in renal allotransplantation . Proc Eur Dial Treat Assoc 5:264, 1968. 2. Van Slyke DD, Phillips RA, Hamilton PB, et al: Effects of shock on the kidney . Trans Assoc Am Physicians 58:119-127, 1944. 3. Hamilton PB, Philips RA, Hillier A: Duration of renal ischemia required to produce uraemia . Am J Physiol 152:517-522, 1948. 4. Badenoch AW, Darmady EM: The effects of temporary occlusion of the renal artery in rabbits and its relationship to traumatic uraemia . J Pathol Bacteriol 59:79-94, 1947.Crossref 5. Scarff RW, Keele CA: The effects of temporary occlusion of the renal circulation in the rabbit . Br J Exp Pathol 24:147-149, 1943. 6. Craddock GN, Milton SH: Comparison of two methods of testing kidneys damaged by ischaemia . Br J Surg 56:381, 1969. 7. Muir R: Textbook of Pathology . DF Cappell (rev), London, Edward Arnold & Co, 1968, p 596. 8. Kleiber M: Body size and metabolic rate . Physiol Rev 27:511-541, 1947. 9. Krebs HA: Body size and tissue respiration . Biochem Biophys Acta 4:249-269, 1950.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Species Differences in Response to Renal Ischemia

Craddock, Graham N.
Archives of Surgery , Volume 111 (5) – May 1, 1976
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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1976.01360230082016
Publisher site
See Article on Publisher Site

Abstract

Abstract • Different species appear to tolerate different amounts of renal ischemia. It is suggested that all kidneys are equally susceptible to ischemic damage, but that the whole animal response varies between species. Mice, rats, rabbits, and pigs were subjected to bilateral nephrectomy. Large animals had relatively smaller kidneys and survived longer than smaller animals. Therefore, the larger the animal, the more time available for recovery of a kidney damaged by ischemia. This adequately explains the apparent species differences in susceptibility to renal ischemia, which are only seen when the kidney is expected to support life immediately. Simple relationships are described, relating metabolic rate, body size, and survival time with no renal function. (Arch Surg 111:582-584, 1976) References 1. Clegg JF, Kulatilake AE, Chisholm GD, et al: The significance of ischaemia in renal allotransplantation . Proc Eur Dial Treat Assoc 5:264, 1968. 2. Van Slyke DD, Phillips RA, Hamilton PB, et al: Effects of shock on the kidney . Trans Assoc Am Physicians 58:119-127, 1944. 3. Hamilton PB, Philips RA, Hillier A: Duration of renal ischemia required to produce uraemia . Am J Physiol 152:517-522, 1948. 4. Badenoch AW, Darmady EM: The effects of temporary occlusion of the renal artery in rabbits and its relationship to traumatic uraemia . J Pathol Bacteriol 59:79-94, 1947.Crossref 5. Scarff RW, Keele CA: The effects of temporary occlusion of the renal circulation in the rabbit . Br J Exp Pathol 24:147-149, 1943. 6. Craddock GN, Milton SH: Comparison of two methods of testing kidneys damaged by ischaemia . Br J Surg 56:381, 1969. 7. Muir R: Textbook of Pathology . DF Cappell (rev), London, Edward Arnold & Co, 1968, p 596. 8. Kleiber M: Body size and metabolic rate . Physiol Rev 27:511-541, 1947. 9. Krebs HA: Body size and tissue respiration . Biochem Biophys Acta 4:249-269, 1950.Crossref

Journal

Archives of Surgery – American Medical Association

Published: May 1, 1976

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