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Membranous Glomerulonephritis: An Initial Symptom of Gastric Carcinoma?

Membranous Glomerulonephritis: An Initial Symptom of Gastric Carcinoma? Abstract A 51-year-old man was hospitalized and operated on for gastric carcinoma with widespread metastases and died two months after the laparatomy and biopsy examination. Two years prior to the operation, he developed nephrotic syndrome. Anaplastic carcinoma, linitis plastica form, of the stomach was found in the tumor biopsy examination and at autopsy. Light and electron microscopical studies of the kidney biopsy specimen taken at laparatomy confirmed the presence of membranous glomerulopathy. An immunologic basis of the concomitant appearance of malignant neoplasms and nephrotic syndrome is possible, based on reported cases. There is also a possibility that renal damage occurs more commonly in malignant neoplasms, but is not recognized clinically. References 1. Greenberg E, Divertie MB, Woolner LB: A review of unusual systemic manifestation associated with carcinoma . Am J Med 36:106-120, 1964.Crossref 2. Brown CH: Systemic manifestation of carcinoma: I. Introduction: General consideration . Am Pract 12:640-644, 1961. 3. Dubois EL: Lupus Erythematosus: A Review of the Current Status of Discoid and Systematic Lupus Erythematosus and Their Variants . New York, McGraw-Hill Book Co Inc, 1966, p 479. 4. Chamberlain MY, Whittaker SR: Hashimoto's disease, dermatomyositis and ovarian carcinoma . Lancet 1:1398-1399, 1963.Crossref 5. Arundell FD, Wilkinson RD, Haserick JR: Dermatomyositis and malignant neoplasms in adults: A survey of 20 years' experience . Arch Dermatol 82:772-775, 1960.Crossref 6. Curtis AC, Heckman JH, Wheeler AH: Study of the auto immune reaction in dermatomyositis . JAMA 178:571-573, 1961.Crossref 7. Grace JT Jr, Dao TL: Dermatomyositis in cancer: A possible etiological mechanism . Cancer 12:648-650, 1959.Crossref 8. Coring, cited by Tapie J, Laporte J, Ricalens SUC: Syndrome nephrotique au cours de la maladie de Hodgkin-Sternberg . Presse Med 65:287-288, 1957. 9. Kimball KG: Amyloidosis in association with neoplastic disease: Report of an unusual case and clinicopathological experience at memorial center for cancer and allied diseases during 11 years (1948-1958) . Ann Intern Med 55:958-974, 1961.Crossref 10. Richmond J, Sherman RS, Diamond HD, et al: Renal lesions associated with malignant lymphomas . Am J Med 32:184-207, 1962.Crossref 11. Sherman MJ, Morales JB, Bayrd ED, et al: Amyloid nephrosis secondary to Hodgkin's disease: Report of a case . Arch Intern Med 95:618-621, 1955.Crossref 12. Winawer SJ, Feldman SM: Amyloid nephrosis in Hodgkin's disease . Arch Intern Med 104:793-796, 1959.Crossref 13. Hamburger J, Richet G, Crossiner J: Nephrology . Philadelphia, WB Saunders Co, 1968, vol 1, p 226. 14. Harrison CV, Milne ND, Steiner RE: Clinical aspects of renal vein thrombosis . Q J Med 25:285-298, 1956. 15. McDonald JR: The prognostic significance of thrombosis of the renal vein secondary to malignant neoplasms of the kidney . Proc Mayo Clin 18:289-297, 1943. 16. O'Beirn S: Renal vein thrombosis in amyloidosis . Ir J Med Sci 6:181-188, 1953. 17. Solsona Conillera J: Linfogranulomatosis maligna: Forma monoganglionar y nefrösica . Med Clin 20:37-39, 1953. 18. Rohmer P, Sacrez R: Un cas de néphrose lipoidique au cours d'une maladie de Hodgkin . Strasb Med 108:45-55, 1948. 19. Jackson RH, Co M: Nephrotic syndrome with Hodgkin's disease . Lancet 2:821-822, 1971.Crossref 20. Tapie J, Laporte J, Richalens SUC: Syndrome néphrotique au cours de la maladie de Hodgkin-Sternberg . Presse Med 65:287-293, 1957. 21. Miller DG: The association of immune disease and malignant lymphoma . Ann Intern Med 66:507-521, 1967.Crossref 22. Plager J, Stutzman L: Acute nephrotic syndrome as a manifestation of acute Hodgkin's disease . Am J Med 50:56-66, 1971.Crossref 23. Lowry WS, Lynch GA: Nephrotic syndrome in Hodgkin's disease . Lancet 1:1127, 1971.Crossref 24. Bichel J, Jensen KB: Nephrotic syndrome and Hodgkin's disease . Lancet 2:1425-1426, 1971.Crossref 25. Brodovsky HS, Samuela ML, Migloire PJ, et al: Chronic lymphocytic leukemia, Hodgkin's disease and the nephrotic syndrome . Arch Intern Med 121:71-75, 1968.Crossref 26. Sherman RL, Sartiano GP, Vinciguerra VP, et al: Nephrotic syndrome in Hodgkin's disease , abstracted. Ann Intern Med 72:805, 1970.Crossref 27. Ghosh L, Muehrcke RC: The nephrotic syndrome: A prodrome to lymphoma . Ann Intern Med 72:379-382, 1970.Crossref 28. Froom DW, Franklin WA, Hano JE, et al: Immune deposits in Hodgkin's disease with nephrotic syndrome . Arch Pathol 94:547-553, 1972. 29. Kiely JM, Wagoner RD, Holley KF: Renal complication of lymphoma . Ann Intern Med 71:1159-1175, 1969.Crossref 30. Muggia FM, Ultmann JE: Glomerulonephritis or nephrotic syndrome in malignant lymphoma, reticulum-cell type . Lancet 1:805, 1971.Crossref 31. Lee JC, Yamauchi H, Hopper J Jr: The association of cancer and nephrotic syndrome . Ann Intern Med 64:41-51, 1966.Crossref 32. Loughridge L, Lewis MG: Nephrotic syndrome in malignant disease of non-renal origin . Lancet 1:256-258, 1971.Crossref 33. Revol L, Viala JJ, Revillard JP, et al: Protéinurie associée à des manifestations paranéoplasiques au cours d'un cancer bronchique . Lyon Med 212:907-916, 1964. 34. Cjassagnon C, Robillard J: Syndrome nephrotique revelatsur d'un cancer bronchique . Lyon Med 213:1063-1074, 1965. 35. Zunin C, Soave F: Association of nephrotic syndrome and nephroblastoma in siblings . Ann Pediatr 203:29-38, 1964. 36. Cantrell EG: Nephrotic syndrome cured by removal of gastric carcinoma . Br Med J 2:739-740, 1969.Crossref 37. Castleman B: Case records of the Massachusetts General Hospital: Case 29-1963 . N Engl J Med 268:943-953, 1963.Crossref 38. Lumeng J, Moran JF: Carotid body tumor associated with mild membranous glomerulonephritis . Ann Intern Med 65:1266-1270, 1966.Crossref 39. Scott RB: Chronic lymphocytic leukemia . Lancet 1:1162-1167, 1957.Crossref 40. Ehrenreich T, Churg J: Pathology of membranous nephropathy , in Sommers SC (ed): Pathology Annual . New York, Appleton-Century Crofts Inc, 1968, pp 145-186. 41. McCluskey RT, Vassalli P, Gallo G, et al: An immunofluorescent study of pathogenic mechanism in glomerular diseases . N Engl J Med 274:695-701, 1966.Crossref 42. Vernier RL, Worthen HG, Good RA: The pathology of the nephrotic syndrome . J Pediatr 58:620-639, 1961.Crossref 43. Dixon FJ, Feldman JD, Vasquez JJ: Experimental glomerulonephritis: The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis . J Exp Med 113:899-920, 1961.Crossref 44. Lee JC, Dushkin M, Eyring EJ, et al: Renal lesions associated with gold therapy: Light and electron microscopic studies . Arthritis Rheum 8:1-12, 1965.Crossref 45. Pollak VE, Pirani CL, Sesking C, et al: Bilateral renal vein thrombosis: Clinical and electron microscopic studies of a case with complete recovery after anticoagulant therapy . Ann Intern Med 65:1056-1071, 1966.Crossref 46. Lewis MG, Loughridge LW, Phillips TM: Immunological studies in nephrotic syndrome associated with extrarenal malignant disease . Lancet 2:134-135, 1971.Crossref 47. Bielschowsky M, Helyer BJ, Howie JB: Spontaneous hemolytic anemia in mice of the NZB/B, strain . Proc Univ Otago Med School 37:9-11, 1959. 48. Holmes MC, Burnett FM: The natural history of autoimmune disease in NZB mice: A comparison with the pattern of human autoimmune manifestations . Ann Intern Med 59:265-276, 1963.Crossref 49. Mellors RC: Autoimmune and immunoproliferative disease of NZB/B, mice and hybrids . Int Rev Exp Pathol 5:217-230, 1966. 50. Mellors RC, Shirai T, Aoki T, et al: Wild type gross leukemia virus and pathogenesis of glomerulonephritis of New Zealand mice . J Exp Med 133:113-132, 1971.Crossref 51. Mellors RC, Aoki T, Huebner RJ: Further implication of murine leukemia-like virus in the disorder of NZB mice . J Exp Med 129:1045-1062, 1969.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Membranous Glomerulonephritis: An Initial Symptom of Gastric Carcinoma?

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References (58)

Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1975.01360130065014
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Abstract

Abstract A 51-year-old man was hospitalized and operated on for gastric carcinoma with widespread metastases and died two months after the laparatomy and biopsy examination. Two years prior to the operation, he developed nephrotic syndrome. Anaplastic carcinoma, linitis plastica form, of the stomach was found in the tumor biopsy examination and at autopsy. Light and electron microscopical studies of the kidney biopsy specimen taken at laparatomy confirmed the presence of membranous glomerulopathy. An immunologic basis of the concomitant appearance of malignant neoplasms and nephrotic syndrome is possible, based on reported cases. There is also a possibility that renal damage occurs more commonly in malignant neoplasms, but is not recognized clinically. References 1. Greenberg E, Divertie MB, Woolner LB: A review of unusual systemic manifestation associated with carcinoma . Am J Med 36:106-120, 1964.Crossref 2. Brown CH: Systemic manifestation of carcinoma: I. Introduction: General consideration . Am Pract 12:640-644, 1961. 3. Dubois EL: Lupus Erythematosus: A Review of the Current Status of Discoid and Systematic Lupus Erythematosus and Their Variants . New York, McGraw-Hill Book Co Inc, 1966, p 479. 4. Chamberlain MY, Whittaker SR: Hashimoto's disease, dermatomyositis and ovarian carcinoma . Lancet 1:1398-1399, 1963.Crossref 5. Arundell FD, Wilkinson RD, Haserick JR: Dermatomyositis and malignant neoplasms in adults: A survey of 20 years' experience . Arch Dermatol 82:772-775, 1960.Crossref 6. Curtis AC, Heckman JH, Wheeler AH: Study of the auto immune reaction in dermatomyositis . JAMA 178:571-573, 1961.Crossref 7. Grace JT Jr, Dao TL: Dermatomyositis in cancer: A possible etiological mechanism . Cancer 12:648-650, 1959.Crossref 8. Coring, cited by Tapie J, Laporte J, Ricalens SUC: Syndrome nephrotique au cours de la maladie de Hodgkin-Sternberg . Presse Med 65:287-288, 1957. 9. Kimball KG: Amyloidosis in association with neoplastic disease: Report of an unusual case and clinicopathological experience at memorial center for cancer and allied diseases during 11 years (1948-1958) . Ann Intern Med 55:958-974, 1961.Crossref 10. Richmond J, Sherman RS, Diamond HD, et al: Renal lesions associated with malignant lymphomas . Am J Med 32:184-207, 1962.Crossref 11. Sherman MJ, Morales JB, Bayrd ED, et al: Amyloid nephrosis secondary to Hodgkin's disease: Report of a case . Arch Intern Med 95:618-621, 1955.Crossref 12. Winawer SJ, Feldman SM: Amyloid nephrosis in Hodgkin's disease . Arch Intern Med 104:793-796, 1959.Crossref 13. Hamburger J, Richet G, Crossiner J: Nephrology . Philadelphia, WB Saunders Co, 1968, vol 1, p 226. 14. Harrison CV, Milne ND, Steiner RE: Clinical aspects of renal vein thrombosis . Q J Med 25:285-298, 1956. 15. McDonald JR: The prognostic significance of thrombosis of the renal vein secondary to malignant neoplasms of the kidney . Proc Mayo Clin 18:289-297, 1943. 16. O'Beirn S: Renal vein thrombosis in amyloidosis . Ir J Med Sci 6:181-188, 1953. 17. Solsona Conillera J: Linfogranulomatosis maligna: Forma monoganglionar y nefrösica . Med Clin 20:37-39, 1953. 18. Rohmer P, Sacrez R: Un cas de néphrose lipoidique au cours d'une maladie de Hodgkin . Strasb Med 108:45-55, 1948. 19. Jackson RH, Co M: Nephrotic syndrome with Hodgkin's disease . Lancet 2:821-822, 1971.Crossref 20. Tapie J, Laporte J, Richalens SUC: Syndrome néphrotique au cours de la maladie de Hodgkin-Sternberg . Presse Med 65:287-293, 1957. 21. Miller DG: The association of immune disease and malignant lymphoma . Ann Intern Med 66:507-521, 1967.Crossref 22. Plager J, Stutzman L: Acute nephrotic syndrome as a manifestation of acute Hodgkin's disease . Am J Med 50:56-66, 1971.Crossref 23. Lowry WS, Lynch GA: Nephrotic syndrome in Hodgkin's disease . Lancet 1:1127, 1971.Crossref 24. Bichel J, Jensen KB: Nephrotic syndrome and Hodgkin's disease . Lancet 2:1425-1426, 1971.Crossref 25. Brodovsky HS, Samuela ML, Migloire PJ, et al: Chronic lymphocytic leukemia, Hodgkin's disease and the nephrotic syndrome . Arch Intern Med 121:71-75, 1968.Crossref 26. Sherman RL, Sartiano GP, Vinciguerra VP, et al: Nephrotic syndrome in Hodgkin's disease , abstracted. Ann Intern Med 72:805, 1970.Crossref 27. Ghosh L, Muehrcke RC: The nephrotic syndrome: A prodrome to lymphoma . Ann Intern Med 72:379-382, 1970.Crossref 28. Froom DW, Franklin WA, Hano JE, et al: Immune deposits in Hodgkin's disease with nephrotic syndrome . Arch Pathol 94:547-553, 1972. 29. Kiely JM, Wagoner RD, Holley KF: Renal complication of lymphoma . Ann Intern Med 71:1159-1175, 1969.Crossref 30. Muggia FM, Ultmann JE: Glomerulonephritis or nephrotic syndrome in malignant lymphoma, reticulum-cell type . Lancet 1:805, 1971.Crossref 31. Lee JC, Yamauchi H, Hopper J Jr: The association of cancer and nephrotic syndrome . Ann Intern Med 64:41-51, 1966.Crossref 32. Loughridge L, Lewis MG: Nephrotic syndrome in malignant disease of non-renal origin . Lancet 1:256-258, 1971.Crossref 33. Revol L, Viala JJ, Revillard JP, et al: Protéinurie associée à des manifestations paranéoplasiques au cours d'un cancer bronchique . Lyon Med 212:907-916, 1964. 34. Cjassagnon C, Robillard J: Syndrome nephrotique revelatsur d'un cancer bronchique . Lyon Med 213:1063-1074, 1965. 35. Zunin C, Soave F: Association of nephrotic syndrome and nephroblastoma in siblings . Ann Pediatr 203:29-38, 1964. 36. Cantrell EG: Nephrotic syndrome cured by removal of gastric carcinoma . Br Med J 2:739-740, 1969.Crossref 37. Castleman B: Case records of the Massachusetts General Hospital: Case 29-1963 . N Engl J Med 268:943-953, 1963.Crossref 38. Lumeng J, Moran JF: Carotid body tumor associated with mild membranous glomerulonephritis . Ann Intern Med 65:1266-1270, 1966.Crossref 39. Scott RB: Chronic lymphocytic leukemia . Lancet 1:1162-1167, 1957.Crossref 40. Ehrenreich T, Churg J: Pathology of membranous nephropathy , in Sommers SC (ed): Pathology Annual . New York, Appleton-Century Crofts Inc, 1968, pp 145-186. 41. McCluskey RT, Vassalli P, Gallo G, et al: An immunofluorescent study of pathogenic mechanism in glomerular diseases . N Engl J Med 274:695-701, 1966.Crossref 42. Vernier RL, Worthen HG, Good RA: The pathology of the nephrotic syndrome . J Pediatr 58:620-639, 1961.Crossref 43. Dixon FJ, Feldman JD, Vasquez JJ: Experimental glomerulonephritis: The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis . J Exp Med 113:899-920, 1961.Crossref 44. Lee JC, Dushkin M, Eyring EJ, et al: Renal lesions associated with gold therapy: Light and electron microscopic studies . Arthritis Rheum 8:1-12, 1965.Crossref 45. Pollak VE, Pirani CL, Sesking C, et al: Bilateral renal vein thrombosis: Clinical and electron microscopic studies of a case with complete recovery after anticoagulant therapy . Ann Intern Med 65:1056-1071, 1966.Crossref 46. Lewis MG, Loughridge LW, Phillips TM: Immunological studies in nephrotic syndrome associated with extrarenal malignant disease . Lancet 2:134-135, 1971.Crossref 47. Bielschowsky M, Helyer BJ, Howie JB: Spontaneous hemolytic anemia in mice of the NZB/B, strain . Proc Univ Otago Med School 37:9-11, 1959. 48. Holmes MC, Burnett FM: The natural history of autoimmune disease in NZB mice: A comparison with the pattern of human autoimmune manifestations . Ann Intern Med 59:265-276, 1963.Crossref 49. Mellors RC: Autoimmune and immunoproliferative disease of NZB/B, mice and hybrids . Int Rev Exp Pathol 5:217-230, 1966. 50. Mellors RC, Shirai T, Aoki T, et al: Wild type gross leukemia virus and pathogenesis of glomerulonephritis of New Zealand mice . J Exp Med 133:113-132, 1971.Crossref 51. Mellors RC, Aoki T, Huebner RJ: Further implication of murine leukemia-like virus in the disorder of NZB mice . J Exp Med 129:1045-1062, 1969.Crossref

Journal

Archives of Surgery – American Medical Association

Published: Jul 1, 1975

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