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Second-Look Operation for Colon Carcinoma After Fluorouracil Therapy

Second-Look Operation for Colon Carcinoma After Fluorouracil Therapy Abstract Carcinoma of the colon and rectum is the second leading cause of death from neoplastic disease in the United States. A distressing aspect of this disease is that, in the main, the five-year survival rates following curative resections have not improved significantly over the past decade or two.1,2 Whatever increased survival has occurred generally can be attributed to decreased operative mortality rather than improved therapy. Several refinements in technique, such as bowel stump ligation to prevent anastomotic tumor cell implantation3 and the notouch isolation technique,4 have been described recently; but, except for their possible benefit, the survival data reported by all authors has been uniform.1,2,4,5 Clearly, there is a marked reduction in the five-year survival from 70% to 80% to approximately 40% when a tumor metastasizes to the regional lymph nodes (Duke's C), and a lesser reduction to 50% to 60% when the tumor extends through References 1. McSherry CK, Cornell GN, Glenn F: Carcinoma of the colon and rectum . Ann Surg 169:502-509, 1969.Crossref 2. Copeland EM, Miller LD, Jones RS: Prognostic factors in carcinoma of the colon and rectum . Amer J Surg 116:875-881, 1968.Crossref 3. Cole WH, Roberts SS, Strehl FW: Modern concepts in cancer of the colon and rectum . Cancer 19:1347-1358, 1966.Crossref 4. Turnbull RB, Kyle K, Watson FR, et al: Cancer of the colon: The influence of the no-touch isolation technic on survival rates . Ann Surg 166:420-427, 1967.Crossref 5. Gilchrist RK, David VC: Consideration of pathological factors influencing five-year survival in radical resection of large bowel and rectum for carcinoma . Ann Surg 126:421-438, 1947.Crossref 6. Wangensteen OH: Cancer of colon and rectum with special reference to (1) earlier recognition of alimentary tract malignancy; (2) secondary delayed re-entry of the abdomen in patients exhibiting lymph node involvement; (3) subtotal primary excision of the colon; (4) operation in obstruction . Wisconsin Med J 48:591-597, 1949. 7. Griffen WO, Humphrey L, Sosin H: The prognosis and management of recurrent abdominal malignancy . Curr Probi Surg , (April) 1969. 8. Curreri AR, Mackman S: Reoperation in carcinoma of the colon following resection and adjuvant chemotherapy . Surg Gynec Obstet 123:274-276, 1966. 9. Mackman S, Curreri AR: The second-look operation for carcinoma of the colon after administration of 5-fluorouracil . Amer J Surg 115:227-230, 1968.Crossref 10. Skipper HE, Schabel FM, Wilcox WS: Experimental evaluation of potential anticancer agents: XIII. On the criteria and kinetics associated with "curability" of experimental leukemia . Cancer Chemother Rep 35:1-111, 1964. 11. Frei E III: A commentary: Selected considerations regarding chemotherapy as an adjuvant in cancer treatment . Cancer Chemother Rep 50:1-8, 1966. 12. Ansfield FJ: A less toxic fluorouracil dose schedule . JAMA 190:686-688, 1964.Crossref 13. Ansfield FJ: Chemotherapy of Disseminated Solid Tumors . Springfield, Ill, Charles C Thomas Publisher, 1966. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Second-Look Operation for Colon Carcinoma After Fluorouracil Therapy

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References (15)

Publisher
American Medical Association
Copyright
Copyright © 1970 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1970.01340220203034
Publisher site
See Article on Publisher Site

Abstract

Abstract Carcinoma of the colon and rectum is the second leading cause of death from neoplastic disease in the United States. A distressing aspect of this disease is that, in the main, the five-year survival rates following curative resections have not improved significantly over the past decade or two.1,2 Whatever increased survival has occurred generally can be attributed to decreased operative mortality rather than improved therapy. Several refinements in technique, such as bowel stump ligation to prevent anastomotic tumor cell implantation3 and the notouch isolation technique,4 have been described recently; but, except for their possible benefit, the survival data reported by all authors has been uniform.1,2,4,5 Clearly, there is a marked reduction in the five-year survival from 70% to 80% to approximately 40% when a tumor metastasizes to the regional lymph nodes (Duke's C), and a lesser reduction to 50% to 60% when the tumor extends through References 1. McSherry CK, Cornell GN, Glenn F: Carcinoma of the colon and rectum . Ann Surg 169:502-509, 1969.Crossref 2. Copeland EM, Miller LD, Jones RS: Prognostic factors in carcinoma of the colon and rectum . Amer J Surg 116:875-881, 1968.Crossref 3. Cole WH, Roberts SS, Strehl FW: Modern concepts in cancer of the colon and rectum . Cancer 19:1347-1358, 1966.Crossref 4. Turnbull RB, Kyle K, Watson FR, et al: Cancer of the colon: The influence of the no-touch isolation technic on survival rates . Ann Surg 166:420-427, 1967.Crossref 5. Gilchrist RK, David VC: Consideration of pathological factors influencing five-year survival in radical resection of large bowel and rectum for carcinoma . Ann Surg 126:421-438, 1947.Crossref 6. Wangensteen OH: Cancer of colon and rectum with special reference to (1) earlier recognition of alimentary tract malignancy; (2) secondary delayed re-entry of the abdomen in patients exhibiting lymph node involvement; (3) subtotal primary excision of the colon; (4) operation in obstruction . Wisconsin Med J 48:591-597, 1949. 7. Griffen WO, Humphrey L, Sosin H: The prognosis and management of recurrent abdominal malignancy . Curr Probi Surg , (April) 1969. 8. Curreri AR, Mackman S: Reoperation in carcinoma of the colon following resection and adjuvant chemotherapy . Surg Gynec Obstet 123:274-276, 1966. 9. Mackman S, Curreri AR: The second-look operation for carcinoma of the colon after administration of 5-fluorouracil . Amer J Surg 115:227-230, 1968.Crossref 10. Skipper HE, Schabel FM, Wilcox WS: Experimental evaluation of potential anticancer agents: XIII. On the criteria and kinetics associated with "curability" of experimental leukemia . Cancer Chemother Rep 35:1-111, 1964. 11. Frei E III: A commentary: Selected considerations regarding chemotherapy as an adjuvant in cancer treatment . Cancer Chemother Rep 50:1-8, 1966. 12. Ansfield FJ: A less toxic fluorouracil dose schedule . JAMA 190:686-688, 1964.Crossref 13. Ansfield FJ: Chemotherapy of Disseminated Solid Tumors . Springfield, Ill, Charles C Thomas Publisher, 1966.

Journal

Archives of Surgery – American Medical Association

Published: Apr 1, 1970

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