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Intra-abdominal Storage of the Transplanted Canine Heart

Intra-abdominal Storage of the Transplanted Canine Heart Abstract Orthotopic transplantation of the canine heart has a high operative mortality and low incidence of long-term survival.1 Heterotopic transplantation of the canine heart into such positions as the neck, groin, or the heart plus lungs into the abdomen has been generally unsuccessful.2-5 Transplantation of rat heart into the abdomen has been described and the results are more encouraging.6-9 The purpose of this study was to evaluate intra-abdominal storage of the canine heart. Materials and Methods Eighty-six mongrel dogs were used, 43 being selected as recipients with 43 dogs of approximately the same weight as donors. The donor heart is taken from the animal under general anesthesia through a right thoracotomy through the fifth interspace. The animal is heparinized, receiving intravenous heparin, 3 mg/kg body weight, prior to excision of the heart. The right pulmonary veins and pulmonary artery were ligated and transected close to the heart. The References 1. Blunenstock, D.A., et al: Prolonged Survival of Orthotopic Homotransplants of the Heart in Animals Treated with Methotrexate , J Thorac Cardiovasc Surg 46:616-625 (Nov) 1963. 2. Mann, F.C., et al: Transplantation of the Intact Mammalian Heart , Arch Surg 26:219-224 ( (Jan) ) 1933.Crossref 3. Sayegh, S.F., and Creech, O., Jr.: Transplantation of the Homologous Canine Heart , J Thorac Surg 34:692-703 ( (Nov) ) 1957. 4. Reemtsma, K., et al: Studies in Homologous Canine Heart Transplantation with Prolongation of Survival with a Folic Acid Antagonist , Surgery 52:127-133 ( (July) ) 1962. 5. Marcus, E.; Wong, S.N.T.; and Luisada, A.A.: Homologous Heart Grafts , Arch Surg 66:179-191 ( (Jan) ) 1953.Crossref 6. Bui-Mong-Hung, and Vigano, M.: Techniques de Transplantation Cardiaque Intra-Abdominale Chez le Rat , Presse Med 75:2047-2049 ( (Sept) ) 1966. 7. Ono, K.; Lindsey, E.S.; and Creech, O.: Effect of Irradiation on Function of Rat Heart Homografts , Surg Forum 18:255-256, 1967. 8. Abbott, C.P., et al: A Technique for Heart Transplantation in the Rat , Arch Surg 89:645-652 ( (Oct) ) 1964.Crossref 9. Tomita, F.: Heart Homotransplantation in the Rat , Sapporo Med J 30:165-183 ( (Oct) -Nov) 1966. 10. Shumway, N.E.; Lower, R.R.; and Stofer, R.C.: Transplantation of the Heart , Advances Surg 2:265-284, 1966. 11. Lower, R.R.; Dong, E., Jr.; and Shumway, N.E.: Long-term Survival of Cardiac Homografts , Surgery 58:110-119 ( (July) ) 1965. 12. Vanderbeek, R.B., et al: Electrophysiologic Observations During Rejection of Dog Heart Transplants , Surg Forum 19: 239-241, 1968. 13. Shumway, N.E.; Angell, W.W.; and Wuerflein, R.D.: Recent Advances in Cardiac Replacement , Surgery 62:794-796 ( (Oct) ) 1967. 14. Dong, E., Jr., et al: Transplantation of the Heart , Die Chest 48:455-457 ( (Nov) ) 1965.Crossref 15. Starzl, T.E., et al: A Trial with Heterologous Antilymphocyte Globulin in Man , Transplantation Proceedings 1:448, 1969. 16. Starzl, T.E.: Heterologous Antilymphocyte Globulin , New Eng J Med 279:700-703 ( (Sept) ) 1968.Crossref 17. Cooley, D.A., et al: Transplantation of the Human Heart , JAMA 205:479-486 (Aug) 1968.Crossref 18. Alexander, J.L., et al: Antilymphocyte Globulin Pretreatment Combined with Azathioprine in the Prolongation of Dog Renal Allografts , Surg Forum 19:188-190, 1968. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Intra-abdominal Storage of the Transplanted Canine Heart

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References (20)

Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1969.01340180052011
Publisher site
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Abstract

Abstract Orthotopic transplantation of the canine heart has a high operative mortality and low incidence of long-term survival.1 Heterotopic transplantation of the canine heart into such positions as the neck, groin, or the heart plus lungs into the abdomen has been generally unsuccessful.2-5 Transplantation of rat heart into the abdomen has been described and the results are more encouraging.6-9 The purpose of this study was to evaluate intra-abdominal storage of the canine heart. Materials and Methods Eighty-six mongrel dogs were used, 43 being selected as recipients with 43 dogs of approximately the same weight as donors. The donor heart is taken from the animal under general anesthesia through a right thoracotomy through the fifth interspace. The animal is heparinized, receiving intravenous heparin, 3 mg/kg body weight, prior to excision of the heart. The right pulmonary veins and pulmonary artery were ligated and transected close to the heart. The References 1. Blunenstock, D.A., et al: Prolonged Survival of Orthotopic Homotransplants of the Heart in Animals Treated with Methotrexate , J Thorac Cardiovasc Surg 46:616-625 (Nov) 1963. 2. Mann, F.C., et al: Transplantation of the Intact Mammalian Heart , Arch Surg 26:219-224 ( (Jan) ) 1933.Crossref 3. Sayegh, S.F., and Creech, O., Jr.: Transplantation of the Homologous Canine Heart , J Thorac Surg 34:692-703 ( (Nov) ) 1957. 4. Reemtsma, K., et al: Studies in Homologous Canine Heart Transplantation with Prolongation of Survival with a Folic Acid Antagonist , Surgery 52:127-133 ( (July) ) 1962. 5. Marcus, E.; Wong, S.N.T.; and Luisada, A.A.: Homologous Heart Grafts , Arch Surg 66:179-191 ( (Jan) ) 1953.Crossref 6. Bui-Mong-Hung, and Vigano, M.: Techniques de Transplantation Cardiaque Intra-Abdominale Chez le Rat , Presse Med 75:2047-2049 ( (Sept) ) 1966. 7. Ono, K.; Lindsey, E.S.; and Creech, O.: Effect of Irradiation on Function of Rat Heart Homografts , Surg Forum 18:255-256, 1967. 8. Abbott, C.P., et al: A Technique for Heart Transplantation in the Rat , Arch Surg 89:645-652 ( (Oct) ) 1964.Crossref 9. Tomita, F.: Heart Homotransplantation in the Rat , Sapporo Med J 30:165-183 ( (Oct) -Nov) 1966. 10. Shumway, N.E.; Lower, R.R.; and Stofer, R.C.: Transplantation of the Heart , Advances Surg 2:265-284, 1966. 11. Lower, R.R.; Dong, E., Jr.; and Shumway, N.E.: Long-term Survival of Cardiac Homografts , Surgery 58:110-119 ( (July) ) 1965. 12. Vanderbeek, R.B., et al: Electrophysiologic Observations During Rejection of Dog Heart Transplants , Surg Forum 19: 239-241, 1968. 13. Shumway, N.E.; Angell, W.W.; and Wuerflein, R.D.: Recent Advances in Cardiac Replacement , Surgery 62:794-796 ( (Oct) ) 1967. 14. Dong, E., Jr., et al: Transplantation of the Heart , Die Chest 48:455-457 ( (Nov) ) 1965.Crossref 15. Starzl, T.E., et al: A Trial with Heterologous Antilymphocyte Globulin in Man , Transplantation Proceedings 1:448, 1969. 16. Starzl, T.E.: Heterologous Antilymphocyte Globulin , New Eng J Med 279:700-703 ( (Sept) ) 1968.Crossref 17. Cooley, D.A., et al: Transplantation of the Human Heart , JAMA 205:479-486 (Aug) 1968.Crossref 18. Alexander, J.L., et al: Antilymphocyte Globulin Pretreatment Combined with Azathioprine in the Prolongation of Dog Renal Allografts , Surg Forum 19:188-190, 1968.

Journal

Archives of Surgery – American Medical Association

Published: Dec 1, 1969

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