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Serratia marcescens Septicemia: A New Threat in Surgery

Serratia marcescens Septicemia: A New Threat in Surgery Abstract The emergence of Serratia marcescens septicemia as a new threat in surgery is shown by the occurrence of 42 cases of this infection at the University of Cincinnati Medical Center in the seven years between 1962 and 1969. A sharp increase has been documented in 1965 and 1966. In the past the S marcescens has been generally considered to have little or no virulence. Many of the manifestations of S marcescens sepsis are similar to those associated with septicemia caused by other gram-negative organisms. Most of the cases were related to antecedent or concurrent antibiotic therapy, usually employing large dosages. The sources of infections were usually the urinary tract, thrombophlebitis at a continuous intravenous site, or the respiratory tract following respiratory assistance therapy or tracheostomy. The mortality in this series of 42 patients was 40%, indicating its seriousness in debilitated surgical patients with predisposing or preexisting diseases. Recently an increasing References 1. Altemeier, W.A.; Todd, J.C.; and Inge, W.W.: Newer Aspects of Septicemia in Surgical Patients , Arch Surg 92:566-572 ( (Oct) ) 1967.Crossref 2. Stenderup, A.; Faergeman, O.; and Ingerslev, M.: Serratia marcescens Infections in Premature Infants , Acta path Microbiol Scand 68:157-160 ( (Oct) ) 1966. 3. Dodson, W.H.: Serratia marcescens Septicemia , Arch Intern Med 121:145-150 ( (Feb) ) 1968.Crossref 4. Eickhoff, T.C.; Steinhauer, B.W.; and Finland, M.: The Klebsiella Enterobacter-Serratia Division , Ann Intern Med 65:1163 ( (Dec) ) 1966.Crossref 5. Aronson, J.D., and Alderman, I.: The Occurrence and Bacteriological Characteristics of S. marcescens from a Case of Meningitis , J Bact 46:261-267 ( (Sept) ) 1943. 6. Clayton, E., and von Graevenitz, A.: Nonpigmented Serratia marcescens , JAMA 197:1059-1064 ( (Sept 26) ) 1966.Crossref 7. Magnuson, C.W., and Elston, H.R.: Infections Caused by Nonpigmented Serratia , Ann Intern Med 65:409-418 ( (Sept) ) 1966.Crossref 8. Wilfert, J.N.; Barrett, F.F.; and Kass, E.H.: Bacteremia Due to Serratia marcescens , New Eng J Med 279:286-289 ( (Aug 8) ) 1968.Crossref 9. Graber, C.D.; Higgins, L.S.; and Davis, J.S.: Seldom-encountered Agents of Bacterial Meningitis , JAMA 192:956-960 ( (June 14) ) 1965.Crossref 10. Patterson, R.H.; Banister, G.B.; and Knight, V.: Chromobacterial Infection in Man , Arch Intern Med 90:79-86 ( (July) ) 1952.Crossref 11. Bertarelli, E.: Untersuchungen und Beobactungen über die Biologie und Pathogenität des Bacillus prodigiosus , Centr Bakt Parasitenk 34:193-202; 312-322 ( (Feb) -March) 1903. 12. Woodward, H.M.M., and Clark, K.B.: A Case of Infection in Man by the Bacterium prodigiosum , Lancet 1:314-315 ( (Feb 1) ) 1913.Crossref 13. Altemeier, W.A.; Todd, J.C.; and Inge, W.W.: Newer Aspects of Septicemia in Surgical Patients , Arch Surg 92:566-572 ( (April) ) 1966.Crossref 14. Fleming, P.C.; Goldner, M.; and Glass, D.G.: Observations on the Nature, Distribution, and Significance of Cephalosporinase , Lancet 1:1399-1401 ( (June 29) ) 1963.Crossref 15. Edwards, P.R., and Ewing, W.H.: Identification of Enterobacteriacae , ed 2, Minneapolis: Burgess, 1962. 16. Miller, M.E., and Buckler, J.M.: Intracellular Survival and Growth of Serratia marcescens Following Phagocytosis by Human Leukocytes , J Infect Dis 118:149-152 ( (April) ) 1968.Crossref 17. Alexander, J.W.; Hegg, M.; and Altemeier, W.A.: Neutrophil Function in Selected Surgical Disorders , Ann Surg 168:447-458 ( (Sept) ) 1968.Crossref 18. Alexander, J.W.; Windhorst, D.B.; and Good, R.A.: Improved Tests for the Evaluation of Neutrophil Function in Human Disease , J Lab Clin Med 72:136-148 ( (July) ) 1968. 19. Alexander, J.W., and Good, R.A.: Effect of Antibiotics on the Bactericidal Activity of Human Leukocytes , J Lab Clin Med 71:971-983 ( (June) ) 1968. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Serratia marcescens Septicemia: A New Threat in Surgery

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References (20)

Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1969.01340140104015
Publisher site
See Article on Publisher Site

Abstract

Abstract The emergence of Serratia marcescens septicemia as a new threat in surgery is shown by the occurrence of 42 cases of this infection at the University of Cincinnati Medical Center in the seven years between 1962 and 1969. A sharp increase has been documented in 1965 and 1966. In the past the S marcescens has been generally considered to have little or no virulence. Many of the manifestations of S marcescens sepsis are similar to those associated with septicemia caused by other gram-negative organisms. Most of the cases were related to antecedent or concurrent antibiotic therapy, usually employing large dosages. The sources of infections were usually the urinary tract, thrombophlebitis at a continuous intravenous site, or the respiratory tract following respiratory assistance therapy or tracheostomy. The mortality in this series of 42 patients was 40%, indicating its seriousness in debilitated surgical patients with predisposing or preexisting diseases. Recently an increasing References 1. Altemeier, W.A.; Todd, J.C.; and Inge, W.W.: Newer Aspects of Septicemia in Surgical Patients , Arch Surg 92:566-572 ( (Oct) ) 1967.Crossref 2. Stenderup, A.; Faergeman, O.; and Ingerslev, M.: Serratia marcescens Infections in Premature Infants , Acta path Microbiol Scand 68:157-160 ( (Oct) ) 1966. 3. Dodson, W.H.: Serratia marcescens Septicemia , Arch Intern Med 121:145-150 ( (Feb) ) 1968.Crossref 4. Eickhoff, T.C.; Steinhauer, B.W.; and Finland, M.: The Klebsiella Enterobacter-Serratia Division , Ann Intern Med 65:1163 ( (Dec) ) 1966.Crossref 5. Aronson, J.D., and Alderman, I.: The Occurrence and Bacteriological Characteristics of S. marcescens from a Case of Meningitis , J Bact 46:261-267 ( (Sept) ) 1943. 6. Clayton, E., and von Graevenitz, A.: Nonpigmented Serratia marcescens , JAMA 197:1059-1064 ( (Sept 26) ) 1966.Crossref 7. Magnuson, C.W., and Elston, H.R.: Infections Caused by Nonpigmented Serratia , Ann Intern Med 65:409-418 ( (Sept) ) 1966.Crossref 8. Wilfert, J.N.; Barrett, F.F.; and Kass, E.H.: Bacteremia Due to Serratia marcescens , New Eng J Med 279:286-289 ( (Aug 8) ) 1968.Crossref 9. Graber, C.D.; Higgins, L.S.; and Davis, J.S.: Seldom-encountered Agents of Bacterial Meningitis , JAMA 192:956-960 ( (June 14) ) 1965.Crossref 10. Patterson, R.H.; Banister, G.B.; and Knight, V.: Chromobacterial Infection in Man , Arch Intern Med 90:79-86 ( (July) ) 1952.Crossref 11. Bertarelli, E.: Untersuchungen und Beobactungen über die Biologie und Pathogenität des Bacillus prodigiosus , Centr Bakt Parasitenk 34:193-202; 312-322 ( (Feb) -March) 1903. 12. Woodward, H.M.M., and Clark, K.B.: A Case of Infection in Man by the Bacterium prodigiosum , Lancet 1:314-315 ( (Feb 1) ) 1913.Crossref 13. Altemeier, W.A.; Todd, J.C.; and Inge, W.W.: Newer Aspects of Septicemia in Surgical Patients , Arch Surg 92:566-572 ( (April) ) 1966.Crossref 14. Fleming, P.C.; Goldner, M.; and Glass, D.G.: Observations on the Nature, Distribution, and Significance of Cephalosporinase , Lancet 1:1399-1401 ( (June 29) ) 1963.Crossref 15. Edwards, P.R., and Ewing, W.H.: Identification of Enterobacteriacae , ed 2, Minneapolis: Burgess, 1962. 16. Miller, M.E., and Buckler, J.M.: Intracellular Survival and Growth of Serratia marcescens Following Phagocytosis by Human Leukocytes , J Infect Dis 118:149-152 ( (April) ) 1968.Crossref 17. Alexander, J.W.; Hegg, M.; and Altemeier, W.A.: Neutrophil Function in Selected Surgical Disorders , Ann Surg 168:447-458 ( (Sept) ) 1968.Crossref 18. Alexander, J.W.; Windhorst, D.B.; and Good, R.A.: Improved Tests for the Evaluation of Neutrophil Function in Human Disease , J Lab Clin Med 72:136-148 ( (July) ) 1968. 19. Alexander, J.W., and Good, R.A.: Effect of Antibiotics on the Bactericidal Activity of Human Leukocytes , J Lab Clin Med 71:971-983 ( (June) ) 1968.

Journal

Archives of SurgeryAmerican Medical Association

Published: Aug 1, 1969

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