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Rejection of Skin Allografts by Healthy Humans: Relationship of Type of Rejection to Degree of Immunity

Rejection of Skin Allografts by Healthy Humans: Relationship of Type of Rejection to Degree of... Abstract THIS article reports the clinical observations made while performing 149 experimental skin grafts on 51 healthy adult male volunteers. The group of 149 grafts was comprised of 144 allografts and five autografts. The experiment was performed for the specific purpose of preparing a substantial number of human transplantation sera with which to study the normal serologic response of the human to skin allografts. Whether or not genetic disparity, as reflected in anthropologic variation, would influence the host's rejection of an allograft or would influence his serologic response to allografts was thought worthy of study. Three principal observations were made: (1) Rejection occurred in three basic patterns. (2) The degree of host immunity which resulted from an allograft was better related to the pattern of graft rejection than it was to graft survival time. (3) Host immunity, when judged in this way, appeared to reflect histocompatibility differences between host and donor. References 1. Converse, J.M., and Rapaport, F.T.: Vascularization of Skin Autografts and Homografts: An Experimental Study in Man , Ann Surg 143:306-315 (March) 1956.Crossref 2. Ceppellini, R., et al: Survival of Test Skin Grafts in Man: Effect of Genetic Relationship and of Blood Groups Incompatibility , Ann NY Acad Sci 129:421-445, 1966.Crossref 3. Eichwald, E.J.; Wetzel, B.; and Lusgraff, E.C.: Genetic Aspects of Second-Set Skin Grafts in Mice , Transplantation 4:260-273 ( (May) ) 1966.Crossref 4. Ballantyne, D.L., Jr.; Platt, J.M.; and Converse, J.M.: Vascularization of Second-Set Homografts in the Rat With Particular Reference to the White Graft: A Histochemical Study , Transplantation 3:1-9 ( (Jan) ) 1965.Crossref 5. Henry, L., et al: The Rejection of Skin Homografts in the Normal Human Subject: II. Histological Findings , J Clin Invest 41:420-466 ( (March) ) 1962.Crossref 6. Dausset, J., and Rapaport, F.T.: The Role of Blood Group Antigens in Human Histocompatibility , Ann NY Acad Sci 129:408-420 ( (Dec 30) ) 1966.Crossref 7. Kuhns, W.J., et al: Serum Antibody Response to Tissue Transplantation Antigens in Man , Ann NY Acad Sci 120:36-45 ( (Nov 30) ) 1964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Rejection of Skin Allografts by Healthy Humans: Relationship of Type of Rejection to Degree of Immunity

McDonald, John C.
Archives of Surgery , Volume 97 (2) – Aug 1, 1968
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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1968 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1968.01340020170020
Publisher site
See Article on Publisher Site

Abstract

Abstract THIS article reports the clinical observations made while performing 149 experimental skin grafts on 51 healthy adult male volunteers. The group of 149 grafts was comprised of 144 allografts and five autografts. The experiment was performed for the specific purpose of preparing a substantial number of human transplantation sera with which to study the normal serologic response of the human to skin allografts. Whether or not genetic disparity, as reflected in anthropologic variation, would influence the host's rejection of an allograft or would influence his serologic response to allografts was thought worthy of study. Three principal observations were made: (1) Rejection occurred in three basic patterns. (2) The degree of host immunity which resulted from an allograft was better related to the pattern of graft rejection than it was to graft survival time. (3) Host immunity, when judged in this way, appeared to reflect histocompatibility differences between host and donor. References 1. Converse, J.M., and Rapaport, F.T.: Vascularization of Skin Autografts and Homografts: An Experimental Study in Man , Ann Surg 143:306-315 (March) 1956.Crossref 2. Ceppellini, R., et al: Survival of Test Skin Grafts in Man: Effect of Genetic Relationship and of Blood Groups Incompatibility , Ann NY Acad Sci 129:421-445, 1966.Crossref 3. Eichwald, E.J.; Wetzel, B.; and Lusgraff, E.C.: Genetic Aspects of Second-Set Skin Grafts in Mice , Transplantation 4:260-273 ( (May) ) 1966.Crossref 4. Ballantyne, D.L., Jr.; Platt, J.M.; and Converse, J.M.: Vascularization of Second-Set Homografts in the Rat With Particular Reference to the White Graft: A Histochemical Study , Transplantation 3:1-9 ( (Jan) ) 1965.Crossref 5. Henry, L., et al: The Rejection of Skin Homografts in the Normal Human Subject: II. Histological Findings , J Clin Invest 41:420-466 ( (March) ) 1962.Crossref 6. Dausset, J., and Rapaport, F.T.: The Role of Blood Group Antigens in Human Histocompatibility , Ann NY Acad Sci 129:408-420 ( (Dec 30) ) 1966.Crossref 7. Kuhns, W.J., et al: Serum Antibody Response to Tissue Transplantation Antigens in Man , Ann NY Acad Sci 120:36-45 ( (Nov 30) ) 1964.Crossref

Journal

Archives of Surgery – American Medical Association

Published: Aug 1, 1968

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