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Chronic Diarrhea and Failure to Thrive Secondary to Ganglioneuroma

Chronic Diarrhea and Failure to Thrive Secondary to Ganglioneuroma Abstract TUMORS of neural crest origin were generally held to be nonfunctional until 1952 when Hawfield and Daisley1 noted their association with diarrhea. In 1957, Mason and co-authors2 reported elevated urine catecholamine excretion in a patient with neuroblastoma. Rosenstein and Ingleman3 reviewed 18 reported cases of neural crest tumors associated with diarrhea, and Sindhu and Anderson4 reported an additional case in 1965. When associated with diarrhea in children, these tumors usually present as cases of failure to thrive. They are also frequently associated with episodes of hypertension and flushing. In all patients with the symptom of diarrhea, the urinary excretion of vanylmandelic acid (VMA) when measured, was elevated whether the tumor was benign or malignant. This paper reports the case of a child that manifested only chronic diarrhea and failure to thrive, who had no increase in measured VMA excretion nor radiologic or physical evidence of neurogenic References 1. Hawfield, H.H., and Daisley, G.W., Jr.: A Report of a Case of a Functional Adrenal Ganglioneuroma , Clin Proc Child Hosp 8:98-100, 1962. 2. Mason, G.A., et al: Adrenaline-Secreting Neuroblastoma in an Infant , Lancet 2:322-325, 1957.Crossref 3. Rosentein, B.J., and Engelman, K.: Diarrhea in a Child With a Catecholamine-Secreting Ganglioneuroma , J Pediat 63:217-226, 1963.Crossref 4. Sindhu, S., and Anderson, CM.: Ganglioneuroma as a Cause of Diarrhea and Failure to Thrive , Aust Paediat 1:56-60, 1965. 5. Stickler, G.B., et al: Catecholamines and Diarrhea in Ganglioneuroblastoma , Amer J Dis Child 104:598-604, 1962. 6. Espiner, E.A., and Beaven, D.W.: Non-Specific Islet-Cell Tumor of Pancreas With Diarrhea , Quart J Med 31:447-471, 1962. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Chronic Diarrhea and Failure to Thrive Secondary to Ganglioneuroma

Archives of Surgery , Volume 95 (6) – Dec 1, 1967

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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1967.01330180082013
Publisher site
See Article on Publisher Site

Abstract

Abstract TUMORS of neural crest origin were generally held to be nonfunctional until 1952 when Hawfield and Daisley1 noted their association with diarrhea. In 1957, Mason and co-authors2 reported elevated urine catecholamine excretion in a patient with neuroblastoma. Rosenstein and Ingleman3 reviewed 18 reported cases of neural crest tumors associated with diarrhea, and Sindhu and Anderson4 reported an additional case in 1965. When associated with diarrhea in children, these tumors usually present as cases of failure to thrive. They are also frequently associated with episodes of hypertension and flushing. In all patients with the symptom of diarrhea, the urinary excretion of vanylmandelic acid (VMA) when measured, was elevated whether the tumor was benign or malignant. This paper reports the case of a child that manifested only chronic diarrhea and failure to thrive, who had no increase in measured VMA excretion nor radiologic or physical evidence of neurogenic References 1. Hawfield, H.H., and Daisley, G.W., Jr.: A Report of a Case of a Functional Adrenal Ganglioneuroma , Clin Proc Child Hosp 8:98-100, 1962. 2. Mason, G.A., et al: Adrenaline-Secreting Neuroblastoma in an Infant , Lancet 2:322-325, 1957.Crossref 3. Rosentein, B.J., and Engelman, K.: Diarrhea in a Child With a Catecholamine-Secreting Ganglioneuroma , J Pediat 63:217-226, 1963.Crossref 4. Sindhu, S., and Anderson, CM.: Ganglioneuroma as a Cause of Diarrhea and Failure to Thrive , Aust Paediat 1:56-60, 1965. 5. Stickler, G.B., et al: Catecholamines and Diarrhea in Ganglioneuroblastoma , Amer J Dis Child 104:598-604, 1962. 6. Espiner, E.A., and Beaven, D.W.: Non-Specific Islet-Cell Tumor of Pancreas With Diarrhea , Quart J Med 31:447-471, 1962.

Journal

Archives of SurgeryAmerican Medical Association

Published: Dec 1, 1967

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