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Effect of Spleen and Lymph Node Removal on Adenovirus Tumor Growth

Effect of Spleen and Lymph Node Removal on Adenovirus Tumor Growth Abstract REGIONAL lymph node removal has been an established procedure for the treatment of cancer. Recently this concept has been challenged because of the lymphocytes' important role in the hosts' immune response. Much of the stimulus for questioning lymph node excision has come from the expanding field of organ transplantation immunity. Homografts were shown to release antigens which drained to the regional lymph nodes at which site antibodies were formed.1 Numerous experimental studies indicated that this cell-bound antibody was of prime importance in the rejection of the graft.2 It was of interest, therefore, to investigate the regional lymph nodes' influence on tumor growth. Tumors were induced in newborn hamsters at the site of injection by adenovirus type 12 and later transplanted to adult hamsters where progressive growth occurred in the majority of the animals.3 Infectious virus was not identified in these tumors, but a specific complement-fixing antigen was References 1. Jones, C.J.: Transplantation and Immunity , Surg Gynec Obstet 120:1317, 1965. 2. Chase, M.W., and Sulzberger, M.: Cellular Aspects of Immunity, Ciba Foundation Symposium , Boston: Little, Brown and Company, 1960. 3. Huebner, R.J.; Rowe, W.P.; and Lane, W.T.: Oncogenic Effects in Hamsters of Human Adenovirus Types 12 and 18 , Proc Nat Acad Sci USA 48: 2051, 1962.Crossref 4. Bard, D.S.; Hammond, W.G.; and Ketcham, A.S.: Role of the Regional Lymph Nodes in Chemically Induced Tumor Immunity , Surg Forum 16: 110, 1965. 5. Moller, E.: Interaction Between Tumor and Host During Progressive Neoplastic Growth in Histoincompatible Recipients , J Nat Cancer Inst 35: 1053, 1965. 6. Allison, A.C.: Relationship of Cellular and Humoral Immunity in Virus Carcinogenesis , Life Sci 3:1415, 1964.Crossref 7. Hollinshead, A.C., et al: Adenovirus Antibody and Antibody to "T" Antigen (Neoantigen): Location in γ-Globulin , Nature 211:423-424, 1966.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Effect of Spleen and Lymph Node Removal on Adenovirus Tumor Growth

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References (9)

Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1966.01330060115013
Publisher site
See Article on Publisher Site

Abstract

Abstract REGIONAL lymph node removal has been an established procedure for the treatment of cancer. Recently this concept has been challenged because of the lymphocytes' important role in the hosts' immune response. Much of the stimulus for questioning lymph node excision has come from the expanding field of organ transplantation immunity. Homografts were shown to release antigens which drained to the regional lymph nodes at which site antibodies were formed.1 Numerous experimental studies indicated that this cell-bound antibody was of prime importance in the rejection of the graft.2 It was of interest, therefore, to investigate the regional lymph nodes' influence on tumor growth. Tumors were induced in newborn hamsters at the site of injection by adenovirus type 12 and later transplanted to adult hamsters where progressive growth occurred in the majority of the animals.3 Infectious virus was not identified in these tumors, but a specific complement-fixing antigen was References 1. Jones, C.J.: Transplantation and Immunity , Surg Gynec Obstet 120:1317, 1965. 2. Chase, M.W., and Sulzberger, M.: Cellular Aspects of Immunity, Ciba Foundation Symposium , Boston: Little, Brown and Company, 1960. 3. Huebner, R.J.; Rowe, W.P.; and Lane, W.T.: Oncogenic Effects in Hamsters of Human Adenovirus Types 12 and 18 , Proc Nat Acad Sci USA 48: 2051, 1962.Crossref 4. Bard, D.S.; Hammond, W.G.; and Ketcham, A.S.: Role of the Regional Lymph Nodes in Chemically Induced Tumor Immunity , Surg Forum 16: 110, 1965. 5. Moller, E.: Interaction Between Tumor and Host During Progressive Neoplastic Growth in Histoincompatible Recipients , J Nat Cancer Inst 35: 1053, 1965. 6. Allison, A.C.: Relationship of Cellular and Humoral Immunity in Virus Carcinogenesis , Life Sci 3:1415, 1964.Crossref 7. Hollinshead, A.C., et al: Adenovirus Antibody and Antibody to "T" Antigen (Neoantigen): Location in γ-Globulin , Nature 211:423-424, 1966.Crossref

Journal

Archives of Surgery – American Medical Association

Published: Dec 1, 1966

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