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Bacteriology of Large Human Burns Treated With Silver Nitrate

Bacteriology of Large Human Burns Treated With Silver Nitrate Abstract INFECTION of the wounds is responsible for much if not most of the morbidity and mortality that attends thermal injuries. In addition, the conversion of superficial burns to subdermal injuries by bacteria is a common phenomenon that sharply increases morbidity. Therefore, improvement in burn mortality and morbidity rates must necessarily depend upon the development of reliable and safe methods of inhibiting the growth of pathogenic bacteria on the wounds. None of the antibiotics that have been tried during the past 30 years have been consistently effective in accomplishing this; the achievement of true asepsis in burn wound therapy is logistically impracticable, if not theoretically impossible, although some have attempted it.1 The search for a satisfactory way to achieve bacteriostasis on burn wounds led to clinical trials of 0.5% silver nitrate solution, an agent previously known to be highly effective in vitro and in smaller infected wounds of various types. References 1. Haynes, B.W., Jr., and Hench, M.E.: Hospital Isolation System for Preventing Cross-Contamination by Staphylococcal and Pseudomonas Organisms in Burn Wounds , Ann Surg 162:641, 1965.Crossref 2. Moyer, C.A., et al: Treatment of Large Human Burns With 0.5% Silver Nitrate Solution , Arch Surg 90:812, 1965.Crossref 3. Monafo, W.W., and Moyer, C.A.: Effectiveness of Dilute Aqueous Silver Nitrate in the Treatment of Major Burns , Arch Surg 91:200, 1965.Crossref 4. Monafo, W.W., et al: Gas Gangrene and Mixed Clostridial Infection of Muscle Complicating Deep Thermal Burns , Arch Surg 92:212, 1966.Crossref 5. Moncrief, J.A., and Teplitz, C.: Changing Concepts in Burn Sepsis , J Trauma 4:233, 1964.Crossref 6. Order, S.E., et al: The Pathogenesis of 2nd and 3rd Degree Burns and Conversion to Full Thickness Injury , Surg Gynec and Obstet 120:983, 1965. 7. Lowbury, E.J.: Infection of Burns , Brit Med J 5178:994, 1960.Crossref 8. Kefalides, N.A., et al: Evaluation of Antibiotic Prophylaxis and Gamma-Globulin, Plasma, Albumin and Saline-Solution Therapy in Severe Burns , Ann Surg 159:496, 1964.Crossref 9. Birke, G.; Liljedahl, S.O.; and Wickman, K.: Studies on Burns , Acta Chir Scand 259( (suppl) ): 5-48, 1960. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Bacteriology of Large Human Burns Treated With Silver Nitrate

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1966.01330030086019
Publisher site
See Article on Publisher Site

Abstract

Abstract INFECTION of the wounds is responsible for much if not most of the morbidity and mortality that attends thermal injuries. In addition, the conversion of superficial burns to subdermal injuries by bacteria is a common phenomenon that sharply increases morbidity. Therefore, improvement in burn mortality and morbidity rates must necessarily depend upon the development of reliable and safe methods of inhibiting the growth of pathogenic bacteria on the wounds. None of the antibiotics that have been tried during the past 30 years have been consistently effective in accomplishing this; the achievement of true asepsis in burn wound therapy is logistically impracticable, if not theoretically impossible, although some have attempted it.1 The search for a satisfactory way to achieve bacteriostasis on burn wounds led to clinical trials of 0.5% silver nitrate solution, an agent previously known to be highly effective in vitro and in smaller infected wounds of various types. References 1. Haynes, B.W., Jr., and Hench, M.E.: Hospital Isolation System for Preventing Cross-Contamination by Staphylococcal and Pseudomonas Organisms in Burn Wounds , Ann Surg 162:641, 1965.Crossref 2. Moyer, C.A., et al: Treatment of Large Human Burns With 0.5% Silver Nitrate Solution , Arch Surg 90:812, 1965.Crossref 3. Monafo, W.W., and Moyer, C.A.: Effectiveness of Dilute Aqueous Silver Nitrate in the Treatment of Major Burns , Arch Surg 91:200, 1965.Crossref 4. Monafo, W.W., et al: Gas Gangrene and Mixed Clostridial Infection of Muscle Complicating Deep Thermal Burns , Arch Surg 92:212, 1966.Crossref 5. Moncrief, J.A., and Teplitz, C.: Changing Concepts in Burn Sepsis , J Trauma 4:233, 1964.Crossref 6. Order, S.E., et al: The Pathogenesis of 2nd and 3rd Degree Burns and Conversion to Full Thickness Injury , Surg Gynec and Obstet 120:983, 1965. 7. Lowbury, E.J.: Infection of Burns , Brit Med J 5178:994, 1960.Crossref 8. Kefalides, N.A., et al: Evaluation of Antibiotic Prophylaxis and Gamma-Globulin, Plasma, Albumin and Saline-Solution Therapy in Severe Burns , Ann Surg 159:496, 1964.Crossref 9. Birke, G.; Liljedahl, S.O.; and Wickman, K.: Studies on Burns , Acta Chir Scand 259( (suppl) ): 5-48, 1960.

Journal

Archives of Surgery – American Medical Association

Published: Sep 1, 1966

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