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Effects of Graded Hemorrhage on Renal Blood Flow in Unanesthetized Dogs

Effects of Graded Hemorrhage on Renal Blood Flow in Unanesthetized Dogs Abstract IT HAS been demonstrated that anesthesia has an important effect on renal physiology.1-7 With the increasing current interest in shock, the influence of this variable on renal blood flow in the hypovolemic animal should be reevaluated. It is the purpose of this report to describe the effect of graded hemorrhage on renal blood flow in both anesthetized and unanesthetized dogs. Method Six healthy mongrel dogs varying in weight from 14.5 to 23.5 kg (32 to 51.6 lb) were studied. Preliminary blood volumes were inferred following plasma volume determinations using either radio-iodinated serum albumin or Evans Blue Dye. The animals were anesthetized with sodium pentobarbital (25 mg/kg IV). Electromagnetic flowmeter probes * were implanted about the left renal artery after it had been exposed through an incision in the left flank. Extra efforts were made to minimize blood loss during the procedure. With the flowmeters in place and the connectors fixed References 1. Ensco, Salt Lake City, Utah. 2. Bourne, W., et al: The Effects of Amytal Sodium , Surg Gynec Obstet 51:356-360, 1930. 3. Corcoran, A.C., and Page, I.H.: Effects of Anesthetic Dosage of Pentobarbital Sodium on Renal Function and Blood Pressure in Dogs , Amer J Phys 140:234-239, 1943. 4. Ekstein, J.W.; Hamilton, W.K.; and McCammond, J.M.: The Effect of Thiopentathol on Peripheral Venous Tone , Anesthesiology 22:525, 1961.Crossref 5. Hershey, S.G.; Zweifach, B.W.; and Rovenstine, E. A.: Effects of Depth of Anesthesia on Behavior of Peripheral Vascular Bed , Anesthesiology 14:245, 1953.Crossref 6. Holman, D.V., and Page, I.H.: Cardiac Output in Arterial Hypertension: Study of Arterial Hypertension Produced by Constricting Renal Arteries in Unanesthetized and Anesthetized (Pentobarbital) Dogs , Amer Heart J 16:321, 1938.Crossref 7. Korner, P.I.: Renal Blood Flow, Glomerular Filtration Rate, Renal PAH Extraction Ratio and the Role of the Renal Vasomotor Nerves in the Anesthetized Rabbit , Circ Res 12:353-360, 1963.Crossref 8. Papper, S., and Papper, E.M.: The Effects of Pre-Anesthetic, Anesthetic and Post-Operative Drugs on Renal Function , Clin Pharmacol Ther 5:205-215, 1964. 9. Smith, H.W., et al: The Effects of Spinal Anesthesia on the Circulation in Normal, Unoperated Man With Reference to the Autonomy of the Arterioles and Especially Those of the Renal Circulation , J Clin Invest 18:319-341, 1959.Crossref 10. Mylon, E.; Winternitz, M.C.; and Süto-Nägy, G.J.: Studies on Therapy in Traumatic Shock , Amer J Phys 139:313-324, 1943. 11. Theye, R.A., and Tuohy, G.F.: Hemodynamics and Blood Volume During Operation and Ether Anesthesia and Unreplaced Blood Loss , Anesthesiology 25:6-14, 1964.Crossref 12. Lauson, H.D.; Bradley, S.; and Cournand, A.: The Renal Circulation in Shock , J Clin Invest 23:381-402, 1944.Crossref 13. MacLean, L.D.: Blood Volume Versus Central Venous Pressure in Shock , Surg Gynec Obstet 118:594, 1964. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Effects of Graded Hemorrhage on Renal Blood Flow in Unanesthetized Dogs

KING, THOMAS C.; ZIMMERMAN, J. M.
Archives of Surgery , Volume 92 (3) – Mar 1, 1966
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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1966.01320210051009
Publisher site
See Article on Publisher Site

Abstract

Abstract IT HAS been demonstrated that anesthesia has an important effect on renal physiology.1-7 With the increasing current interest in shock, the influence of this variable on renal blood flow in the hypovolemic animal should be reevaluated. It is the purpose of this report to describe the effect of graded hemorrhage on renal blood flow in both anesthetized and unanesthetized dogs. Method Six healthy mongrel dogs varying in weight from 14.5 to 23.5 kg (32 to 51.6 lb) were studied. Preliminary blood volumes were inferred following plasma volume determinations using either radio-iodinated serum albumin or Evans Blue Dye. The animals were anesthetized with sodium pentobarbital (25 mg/kg IV). Electromagnetic flowmeter probes * were implanted about the left renal artery after it had been exposed through an incision in the left flank. Extra efforts were made to minimize blood loss during the procedure. With the flowmeters in place and the connectors fixed References 1. Ensco, Salt Lake City, Utah. 2. Bourne, W., et al: The Effects of Amytal Sodium , Surg Gynec Obstet 51:356-360, 1930. 3. Corcoran, A.C., and Page, I.H.: Effects of Anesthetic Dosage of Pentobarbital Sodium on Renal Function and Blood Pressure in Dogs , Amer J Phys 140:234-239, 1943. 4. Ekstein, J.W.; Hamilton, W.K.; and McCammond, J.M.: The Effect of Thiopentathol on Peripheral Venous Tone , Anesthesiology 22:525, 1961.Crossref 5. Hershey, S.G.; Zweifach, B.W.; and Rovenstine, E. A.: Effects of Depth of Anesthesia on Behavior of Peripheral Vascular Bed , Anesthesiology 14:245, 1953.Crossref 6. Holman, D.V., and Page, I.H.: Cardiac Output in Arterial Hypertension: Study of Arterial Hypertension Produced by Constricting Renal Arteries in Unanesthetized and Anesthetized (Pentobarbital) Dogs , Amer Heart J 16:321, 1938.Crossref 7. Korner, P.I.: Renal Blood Flow, Glomerular Filtration Rate, Renal PAH Extraction Ratio and the Role of the Renal Vasomotor Nerves in the Anesthetized Rabbit , Circ Res 12:353-360, 1963.Crossref 8. Papper, S., and Papper, E.M.: The Effects of Pre-Anesthetic, Anesthetic and Post-Operative Drugs on Renal Function , Clin Pharmacol Ther 5:205-215, 1964. 9. Smith, H.W., et al: The Effects of Spinal Anesthesia on the Circulation in Normal, Unoperated Man With Reference to the Autonomy of the Arterioles and Especially Those of the Renal Circulation , J Clin Invest 18:319-341, 1959.Crossref 10. Mylon, E.; Winternitz, M.C.; and Süto-Nägy, G.J.: Studies on Therapy in Traumatic Shock , Amer J Phys 139:313-324, 1943. 11. Theye, R.A., and Tuohy, G.F.: Hemodynamics and Blood Volume During Operation and Ether Anesthesia and Unreplaced Blood Loss , Anesthesiology 25:6-14, 1964.Crossref 12. Lauson, H.D.; Bradley, S.; and Cournand, A.: The Renal Circulation in Shock , J Clin Invest 23:381-402, 1944.Crossref 13. MacLean, L.D.: Blood Volume Versus Central Venous Pressure in Shock , Surg Gynec Obstet 118:594, 1964.

Journal

Archives of Surgery – American Medical Association

Published: Mar 1, 1966

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