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Derivation of Fibroblasts in the Healing Wound

Derivation of Fibroblasts in the Healing Wound Abstract Understanding of the biochemistry of fibrogenesis in wound repair has increased steadily. Recent advances in knowledge of this process have been reviewed by Grillo,21 Harkness,24 and Jackson,31 among others. Correspondingly little increment had occurred in comprehension of the mechanisms of cellular stimulation prior to beginning of fibrogenesis or of regulation of proliferation and productivity of cells thereafter. Recently there has been renewed interest in an early phase of this problem—the question of site of origin of fibroblasts in wound repair. New contributions are reviewed against the background of the ancient and continuing controversy over histogenous against vascular derivation of fibroblasts. Origins of Controversy Virchow's belief in the immutable lineage of cells found expression in the assertions by Marchand 38 and Aschoff 4 on histologic grounds that fibroblasts in wound healing were derived from the connective tissues of the wound. Maximow, however, studying fixed sections of inflammatory exudate References 1. Allgöwer, M.: The Cellular Basis of Wound Repair , Springfield, Ill: Charles C Thomas, Publisher, 1956. 2. Allgöwer, M., and Hulliger, L.: Origin of Fibroblasts From Mononuclear Blood Cells: A Study of in Vitro Formation of the Collagen Precursor, Hydroxyproline, in Buffy Coat Cultures , Surgery 47:603-610, 1960. 3. Arey, L. B.: Wound Healing , Physiol Rev 16:327-406, 1936. 4. Aschoff, L.: Das reticulo-endotheliale System , Ergbn Inn Med Kinderheilk 26:1, 1924. 5. Bloom, W.: Mammalian Lymph in Tissue Culture: From Lymphocyte to Fibroblast , Arch Exp Zellforsch 5:269-307, 1928. 6. Butler, E. G., and O'Brien, J. P.: Effects of Localized X-Radiation on Regeneration of the Urodele Limb , Anat Rec 84:407, 1942.Crossref 7. Carrel, A., and Ebeling, A. H.: Pure Cultures of Large Mononuclear Leucocytes , J Exp Med 36:365-383, 1922.Crossref 8. Carrel, A., and Ebeling, A. H.: The Trans-formation of Monocytes Into Fibroblasts Through the Action of Rous Virus , J Exp Med 43:461-467, 1926.Crossref 9. Chalkley, D. T.: "The Cellular Basis of Limb Regeneration," chap III in Regeneration in Vertebrates , edited by C. S. Thornton, Chicago: University of Chicago Press, 1959, pp 34-58. 10. Clark, E. R.; Kirby-Smith, H. T.; Rex, R. O.; and Williams, R. G.: Recent Modifications in the Method of Studying Living Cells and Tissues in Transparent Chambers Inserted in the Rabbit's Ear , Anat Rec 47:187, 1930.Crossref 11. Clark, E. R., and Clark, E. L.: Microscopic Observations of Growth of Blood Capillaries in Living Mammal , Amer J Anat 64:251-301, 1939.Crossref 12. Cohnheim, J.: Über Entzündung und Eiterung , Virchow Arch Path Anat 40:1-79, 1867.Crossref 13. Ebert, R. H., and Florey, H. W.: The Extravascular Development of the Monocyte Observed in Vivo , Brit J Exp Path 20:342-356, 1939. 14. Ebert, R. H.; Sanders, A. G.; and Florey, H. W.: Observations of Lymphocytes in Chambers in the Rabbit's Ear , Brit J Exp Path 21:212-218, 1940. 15. Edwards, L. C., and Dunphy, J. E.: Wound Healing: 1. Injury and Normal Repair , New Eng J Med 259:224-233, 1958.Crossref 16. Foot, N. C.: Studies on Endothelial Reactions: V. The Endothelium in the Healing of Aseptic Wounds in the Omentum of Rabbits , J Exp Med 34:625-642, 1921.Crossref 17. Foot, N. C.: The Endothelial Phagocyte: A Critical Review , Anat Rec 30:15-51, 1925.Crossref 18. Gillman, T., and Penn, J.: Studies on the Repair of Cutaneous Wounds , Med Proc 2:121-186, 1956. 19. Gowans, J. L.: The Effect of the Continuous Re-Infusion of Lymph and Lymphocytes on the Output of Lymphocytes From the Thoracic Duct of Unanesthetized Rats , Brit J Exp Path 38:67-78, 1957. 20. Grillo, H. C.: Origin of Fibroblasts in Wound Healing: An Autoradiographic Study of Inhibition of Cellular Proliferation by Local X-Irradiation , Ann Surg 157:453-467, 1963.Crossref 21. Grillo, H. C.: "Aspects of the Origin, Synthesis and Evolution of Fibrous Tissue in Wound Repair," in Advances in Biology of Skin: Wound Healing, edited by R. Billingham and W. Montagna, New York: Pergamon Press, to be published. 22. Grillo, H. C., and Potsaid, M. S.: Studies in Wound Healing: IV Retardation of Contraction by Local X-Irradiation, and Observations Relating to the Origin of Fibroblasts in Repair , Ann Surg 154: 741-750, 1961. 23. Hall, J. W., and Furth, F.: Cultural Studies on the Relationship of Lymphocytes to Monocytes and Fibroblasts , Arch Path 25:46-59, 1938. 24. Harkness, R. D.: Biological Functions of Collagen , Biol Rev 36:399-463, 1961.Crossref 25. Hartwell, S. W.: Surgical Wounds in Human Beings: II. Fibrous Healing , Arch Surg 21: 76-96, 1930.Crossref 26. Hartwell, S. W.: The Mechanisms of Healing in Human Wounds , Springfield, Ill: Charles C Thomas, Publisher, 1955. 27. Hay, E. D., and Fischman, D. A.: Origin of the Blastema in Regenerating Limbs of the Newt Triturus Viridescens , Develop Biol 3:26-59, 1961.Crossref 28. Howes, E. L., and Harvey, S. C.: The Clinical Significance of Experimental Studies in Wound Healing , Ann Surg 102:941-946, 1935.Crossref 29. Hulliger, L.: Über die unterschiedlichen Entwicklungsfähigkeiten der Zellen des Blutes und der Lymphe in Vitro , Virchow Arch Path Anat 329:289-318, 1956.Crossref 30. Hulliger, L., and Allgöwer, M.: Proliferation und Differenzierung monocytarer Zellen des peripheren Blutes , Schweiz Med Wschr 91:1201-1207, 1961. 31. Jackson, D. S.: Some Biochemical Aspects of Fibrogenesis and Wound Healing , New Eng J Med 259:814-820, 1958.Crossref 32. Johnson, F. R., and McMinn, R. M. H.: The Cytology of Wound Healing of Body Surfaces in Mammals , Biol Rev 35:364-412, 1960.Crossref 33. Kelsall, M. A., and Crabb, E. D.: Lymphocytes and Plasmacytes in Nucleoprotein Metabolism , Ann NY Acad Sci 72:295-337, 1958.Crossref 34. Kolouch, F.: The Lymphocytes in Acute Inflammation , Amer J Path 15:413-428, 1939. 35. Kreyberg, L.: The Prospective Potencies of the Human Lymphocyte , Arch Exp Zellforsch 8: 359-364, 1929. 36. Lawrence, J. S.; Pearse, H. E.; and Mider, G. B.: Effect of Experimental Neutropenia on the Healing of Wounds , Arch Path 28:32-36, 1939. 37. MacDonald, R. A.: Origin of Fibroblasts in Experimental Healing Wounds: Autoradiographic Studies Using Tritiated Thymidine , Surgery 46:376-382, 1959. 38. Marchand, F.: Der Prozess der Wundheilung mit Einschluss der Transplantation, Stuttgart: 1901. 39. Maximow, A.: Experimentelle Untersuchungen über entzündliche Neubildung von Rindegewebe , Beitr Path Anat suppl 5: 1902. 40. Maximow, A.: Relation of Blood Cells to Connective Tissue and Endothelium , Physiol Rev 4:533-560, 1924. 41. Maximow, A.: Development of Non-granular Leucocytes (Lymphocytes and Monocytes) Into Polyblasts (Macrophages) and Fibroblasts in Vitro , Proc Soc Exp Biol Med 24:570-572, 1926-7.Crossref 42. Maximow, A.: Cultures of Blood Leukocytes: From Lymphocytes and Monocytes to Connective Tissue , Arch Exp Zellforsch 5:169-268, 1928. 43. Medawar, J.: Observations on Lymphocytes in Tissue Culture , Brit J Exp Path 21:205-211, 1940. 44. Metchnikoff, E.: Leçons sur la pathologie comparée de l'inflammation , Paris: Masson & Cie, 1892. 45. Moschowitz, E.: Relation of Lymphocyte Infiltration of Inflammatory Origin to Angiogenesis , Arch Path 49:247-266, 1950. 46. Petrakis, N. L.: In Vivo Cultivation of Leukocytes in Diffusion Chambers: Requirement of Ascorbic Acid for Differentiation of Mononuclear Leukocytes to Fibroblasts , Blood 18:310-316, 1961. 47. Petrakis, N. L.; Davis, M.; and Lucia, S. P.: The in Vivo Differentiation of Human Leukocytes Into Histiocytes, Fibroblasts and Fat Cells in Subcutaneous Diffusion Chambers , Blood 17:109-118, 1961. 48. Ross, R., and Benditt, E. P.: Wound Healing and Collagen Formation: I. Sequential Changes in Components of Guinea Pig Skin Wounds Observed in the Electron Microscope , Biophys Biochem Cytol 11:677-700, 1961.Crossref 49. Sandison, J. C.: The Transparent Chamber of the Rabbit's Ear , Amer J Anat 41:447, 1928.Crossref 50. Schilling, J. A.; Favata, B. V.; and Radakovich, M.: Studies of Fibroplasia in Wound Healing , Surg Gynec Obstet 96:143-149, 1953. 51. Shelton, E.: Differences in the Potentialities of Normal and Malignant Lymphocytes Grown in Diffusion Chambers , Path Biol (Paris) 9:542-544, 1961. 52. Shelton, E., and Rice, M. E.: Growth of Normal Peritoneal Cells in Diffusion Chambers: A Study in Cell Modulation , Amer J Anat 105:281-342, 1959.Crossref 53. Sieracki, J. C., and Rebuck, J. W.: "Role of the Lymphocyte in Inflammation," in The Lymphocyte and Lymphocytic Tissue , edited by J. W. Rebuck, New York: Paul B. Hoeber, Inc., Medical Book Department of Harper & Brothers, 1960, pp 71-81. 54. Spear, F. G.: Some Biological Aspects of Experimental Radiology , Int Rev Cytol 7:1-77, 1958. 55. Stearns, M. L.: Studies on Development of Connective Tissue in Transparent Chambers in Rabbit's Ear , Amer J Anat 66:133-176, 1940.Crossref 56. Trowell, O. A.: The Lymphocyte , Int Rev Cytol 7:236-293, 1958. 57. Weiss, P.: Perspectives in the Field of Morphogenesis , Quart Rev Biol 25:1777, 1950.Crossref 58. Yoffey, J. M.: The Mammalian Lymphocyte , Biol Rev 25:314-343, 1950.Crossref 59. Yoffey, J. M., and Courtice, F. C.: Lymphatics, Lymph and Lymphoid Tissue , p 414, Cambridge, Mass: Harvard University Press, 1956, p 414. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Derivation of Fibroblasts in the Healing Wound

GRILLO, HERMES C.
Archives of Surgery , Volume 88 (2) – Feb 1, 1964
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References (57)

Publisher
American Medical Association
Copyright
Copyright © 1964 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1964.01310200056013
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Abstract

Abstract Understanding of the biochemistry of fibrogenesis in wound repair has increased steadily. Recent advances in knowledge of this process have been reviewed by Grillo,21 Harkness,24 and Jackson,31 among others. Correspondingly little increment had occurred in comprehension of the mechanisms of cellular stimulation prior to beginning of fibrogenesis or of regulation of proliferation and productivity of cells thereafter. Recently there has been renewed interest in an early phase of this problem—the question of site of origin of fibroblasts in wound repair. New contributions are reviewed against the background of the ancient and continuing controversy over histogenous against vascular derivation of fibroblasts. Origins of Controversy Virchow's belief in the immutable lineage of cells found expression in the assertions by Marchand 38 and Aschoff 4 on histologic grounds that fibroblasts in wound healing were derived from the connective tissues of the wound. Maximow, however, studying fixed sections of inflammatory exudate References 1. Allgöwer, M.: The Cellular Basis of Wound Repair , Springfield, Ill: Charles C Thomas, Publisher, 1956. 2. Allgöwer, M., and Hulliger, L.: Origin of Fibroblasts From Mononuclear Blood Cells: A Study of in Vitro Formation of the Collagen Precursor, Hydroxyproline, in Buffy Coat Cultures , Surgery 47:603-610, 1960. 3. Arey, L. B.: Wound Healing , Physiol Rev 16:327-406, 1936. 4. Aschoff, L.: Das reticulo-endotheliale System , Ergbn Inn Med Kinderheilk 26:1, 1924. 5. Bloom, W.: Mammalian Lymph in Tissue Culture: From Lymphocyte to Fibroblast , Arch Exp Zellforsch 5:269-307, 1928. 6. Butler, E. G., and O'Brien, J. P.: Effects of Localized X-Radiation on Regeneration of the Urodele Limb , Anat Rec 84:407, 1942.Crossref 7. Carrel, A., and Ebeling, A. H.: Pure Cultures of Large Mononuclear Leucocytes , J Exp Med 36:365-383, 1922.Crossref 8. Carrel, A., and Ebeling, A. H.: The Trans-formation of Monocytes Into Fibroblasts Through the Action of Rous Virus , J Exp Med 43:461-467, 1926.Crossref 9. Chalkley, D. T.: "The Cellular Basis of Limb Regeneration," chap III in Regeneration in Vertebrates , edited by C. S. Thornton, Chicago: University of Chicago Press, 1959, pp 34-58. 10. Clark, E. R.; Kirby-Smith, H. T.; Rex, R. O.; and Williams, R. G.: Recent Modifications in the Method of Studying Living Cells and Tissues in Transparent Chambers Inserted in the Rabbit's Ear , Anat Rec 47:187, 1930.Crossref 11. Clark, E. R., and Clark, E. L.: Microscopic Observations of Growth of Blood Capillaries in Living Mammal , Amer J Anat 64:251-301, 1939.Crossref 12. Cohnheim, J.: Über Entzündung und Eiterung , Virchow Arch Path Anat 40:1-79, 1867.Crossref 13. Ebert, R. H., and Florey, H. W.: The Extravascular Development of the Monocyte Observed in Vivo , Brit J Exp Path 20:342-356, 1939. 14. Ebert, R. H.; Sanders, A. G.; and Florey, H. W.: Observations of Lymphocytes in Chambers in the Rabbit's Ear , Brit J Exp Path 21:212-218, 1940. 15. Edwards, L. C., and Dunphy, J. E.: Wound Healing: 1. Injury and Normal Repair , New Eng J Med 259:224-233, 1958.Crossref 16. Foot, N. C.: Studies on Endothelial Reactions: V. The Endothelium in the Healing of Aseptic Wounds in the Omentum of Rabbits , J Exp Med 34:625-642, 1921.Crossref 17. Foot, N. C.: The Endothelial Phagocyte: A Critical Review , Anat Rec 30:15-51, 1925.Crossref 18. Gillman, T., and Penn, J.: Studies on the Repair of Cutaneous Wounds , Med Proc 2:121-186, 1956. 19. Gowans, J. L.: The Effect of the Continuous Re-Infusion of Lymph and Lymphocytes on the Output of Lymphocytes From the Thoracic Duct of Unanesthetized Rats , Brit J Exp Path 38:67-78, 1957. 20. Grillo, H. C.: Origin of Fibroblasts in Wound Healing: An Autoradiographic Study of Inhibition of Cellular Proliferation by Local X-Irradiation , Ann Surg 157:453-467, 1963.Crossref 21. Grillo, H. C.: "Aspects of the Origin, Synthesis and Evolution of Fibrous Tissue in Wound Repair," in Advances in Biology of Skin: Wound Healing, edited by R. Billingham and W. Montagna, New York: Pergamon Press, to be published. 22. Grillo, H. C., and Potsaid, M. S.: Studies in Wound Healing: IV Retardation of Contraction by Local X-Irradiation, and Observations Relating to the Origin of Fibroblasts in Repair , Ann Surg 154: 741-750, 1961. 23. Hall, J. W., and Furth, F.: Cultural Studies on the Relationship of Lymphocytes to Monocytes and Fibroblasts , Arch Path 25:46-59, 1938. 24. Harkness, R. D.: Biological Functions of Collagen , Biol Rev 36:399-463, 1961.Crossref 25. Hartwell, S. W.: Surgical Wounds in Human Beings: II. Fibrous Healing , Arch Surg 21: 76-96, 1930.Crossref 26. Hartwell, S. W.: The Mechanisms of Healing in Human Wounds , Springfield, Ill: Charles C Thomas, Publisher, 1955. 27. Hay, E. D., and Fischman, D. A.: Origin of the Blastema in Regenerating Limbs of the Newt Triturus Viridescens , Develop Biol 3:26-59, 1961.Crossref 28. Howes, E. L., and Harvey, S. C.: The Clinical Significance of Experimental Studies in Wound Healing , Ann Surg 102:941-946, 1935.Crossref 29. Hulliger, L.: Über die unterschiedlichen Entwicklungsfähigkeiten der Zellen des Blutes und der Lymphe in Vitro , Virchow Arch Path Anat 329:289-318, 1956.Crossref 30. Hulliger, L., and Allgöwer, M.: Proliferation und Differenzierung monocytarer Zellen des peripheren Blutes , Schweiz Med Wschr 91:1201-1207, 1961. 31. Jackson, D. S.: Some Biochemical Aspects of Fibrogenesis and Wound Healing , New Eng J Med 259:814-820, 1958.Crossref 32. Johnson, F. R., and McMinn, R. M. H.: The Cytology of Wound Healing of Body Surfaces in Mammals , Biol Rev 35:364-412, 1960.Crossref 33. Kelsall, M. A., and Crabb, E. D.: Lymphocytes and Plasmacytes in Nucleoprotein Metabolism , Ann NY Acad Sci 72:295-337, 1958.Crossref 34. Kolouch, F.: The Lymphocytes in Acute Inflammation , Amer J Path 15:413-428, 1939. 35. Kreyberg, L.: The Prospective Potencies of the Human Lymphocyte , Arch Exp Zellforsch 8: 359-364, 1929. 36. Lawrence, J. S.; Pearse, H. E.; and Mider, G. B.: Effect of Experimental Neutropenia on the Healing of Wounds , Arch Path 28:32-36, 1939. 37. MacDonald, R. A.: Origin of Fibroblasts in Experimental Healing Wounds: Autoradiographic Studies Using Tritiated Thymidine , Surgery 46:376-382, 1959. 38. Marchand, F.: Der Prozess der Wundheilung mit Einschluss der Transplantation, Stuttgart: 1901. 39. Maximow, A.: Experimentelle Untersuchungen über entzündliche Neubildung von Rindegewebe , Beitr Path Anat suppl 5: 1902. 40. Maximow, A.: Relation of Blood Cells to Connective Tissue and Endothelium , Physiol Rev 4:533-560, 1924. 41. Maximow, A.: Development of Non-granular Leucocytes (Lymphocytes and Monocytes) Into Polyblasts (Macrophages) and Fibroblasts in Vitro , Proc Soc Exp Biol Med 24:570-572, 1926-7.Crossref 42. Maximow, A.: Cultures of Blood Leukocytes: From Lymphocytes and Monocytes to Connective Tissue , Arch Exp Zellforsch 5:169-268, 1928. 43. Medawar, J.: Observations on Lymphocytes in Tissue Culture , Brit J Exp Path 21:205-211, 1940. 44. Metchnikoff, E.: Leçons sur la pathologie comparée de l'inflammation , Paris: Masson & Cie, 1892. 45. Moschowitz, E.: Relation of Lymphocyte Infiltration of Inflammatory Origin to Angiogenesis , Arch Path 49:247-266, 1950. 46. Petrakis, N. L.: In Vivo Cultivation of Leukocytes in Diffusion Chambers: Requirement of Ascorbic Acid for Differentiation of Mononuclear Leukocytes to Fibroblasts , Blood 18:310-316, 1961. 47. Petrakis, N. L.; Davis, M.; and Lucia, S. P.: The in Vivo Differentiation of Human Leukocytes Into Histiocytes, Fibroblasts and Fat Cells in Subcutaneous Diffusion Chambers , Blood 17:109-118, 1961. 48. Ross, R., and Benditt, E. P.: Wound Healing and Collagen Formation: I. Sequential Changes in Components of Guinea Pig Skin Wounds Observed in the Electron Microscope , Biophys Biochem Cytol 11:677-700, 1961.Crossref 49. Sandison, J. C.: The Transparent Chamber of the Rabbit's Ear , Amer J Anat 41:447, 1928.Crossref 50. Schilling, J. A.; Favata, B. V.; and Radakovich, M.: Studies of Fibroplasia in Wound Healing , Surg Gynec Obstet 96:143-149, 1953. 51. Shelton, E.: Differences in the Potentialities of Normal and Malignant Lymphocytes Grown in Diffusion Chambers , Path Biol (Paris) 9:542-544, 1961. 52. Shelton, E., and Rice, M. E.: Growth of Normal Peritoneal Cells in Diffusion Chambers: A Study in Cell Modulation , Amer J Anat 105:281-342, 1959.Crossref 53. Sieracki, J. C., and Rebuck, J. W.: "Role of the Lymphocyte in Inflammation," in The Lymphocyte and Lymphocytic Tissue , edited by J. W. Rebuck, New York: Paul B. Hoeber, Inc., Medical Book Department of Harper & Brothers, 1960, pp 71-81. 54. Spear, F. G.: Some Biological Aspects of Experimental Radiology , Int Rev Cytol 7:1-77, 1958. 55. Stearns, M. L.: Studies on Development of Connective Tissue in Transparent Chambers in Rabbit's Ear , Amer J Anat 66:133-176, 1940.Crossref 56. Trowell, O. A.: The Lymphocyte , Int Rev Cytol 7:236-293, 1958. 57. Weiss, P.: Perspectives in the Field of Morphogenesis , Quart Rev Biol 25:1777, 1950.Crossref 58. Yoffey, J. M.: The Mammalian Lymphocyte , Biol Rev 25:314-343, 1950.Crossref 59. Yoffey, J. M., and Courtice, F. C.: Lymphatics, Lymph and Lymphoid Tissue , p 414, Cambridge, Mass: Harvard University Press, 1956, p 414.

Journal

Archives of Surgery – American Medical Association

Published: Feb 1, 1964

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