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Electrolyte Changes During Dilution Perfusion

Electrolyte Changes During Dilution Perfusion Abstract The problems of extracorporeal circulation remain far from being solved, either from the biological or technical standpoints. However, a major step forward has been the introduction of the principle of hemodilution. This modality has reduced certain risks of perfusion, of which the "homologous blood syndrome"4,5 with its associated changes seem to be the most important. The main technical advantage of the method lies in its simplicity, avoiding to a considerable extent the use of homologous blood for priming the heart-lung machine. However, hemodilution violates the fundamental principle of maintenance of the constancy of the milieu interieur by rapidly altering the concentrations of the constituents of the blood. The changes in the concentrations of electrolytes and the consequent readjustments constitute a major aspect of this problem. The alterations depend on the amount and composition of the solutions used for hemodilution and of the ability of the organism to deal with References 1. Available from Travenol Laboratories, Inc., Morton Grove, Ill. 2. Beall, A. C., Jr., and Cooley, D. A.: Renal Hemodynamic Effects of Total Cardiopulmonary Bypass Eliminating Heparinized Blood , American Heart Association Monograph: No. 6, Cardiovascular Surgery 1963, p 820. 3. Cooley, D. A.; Beall, A. C.; and Grondin, P.: Open Heart Operations With Disposable Oxygenators, 5% Dextrose Prime and Normothermia , Surgery 52:713, 1962. 4. DeWall, R. A.; Lillehei, R. C.; and Sellers, R. D.: Hemodilution Perfusions for Open Heart Surgery , New Eng J Med 266:1078, 1962.Crossref 5. Gadboys, H. L.; Slonim, R.; and Litwak, R. S.: Homologous Blood Syndromes: I. Preliminary Observations on Its Relationship to Clinical Cardiopulmonary Bypass , Ann Surg 156:793, 1962.Crossref 6. Litwak, R. S.; Slonim, R.; Wisoff, B. G.; and Gadboys, H. L.: Homologous Blood Syndrome During Extracorporeal Circulation in Man: II. Phenomena of Sequestration and Desequestration , New Eng J Med 268:1377, 1963.Crossref 7. Paton, B. C.: Cardiopulmonary Bypass With Diluted Blood , J Roy Coll Surg (Edinburgh) 8: 301, 1963. 8. Sakai, Y.; Linder, E.; and Paton, B. C.: Physiologic Effects of Rapid Hemodilution by Infusion of Electrolyte Solutions, to be published. 9. Zuhdi, N.; Carey, J.; and Greer, A.: Hemodilution for Body Perfusion , J Okla Med Ass 56:88, 1963. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Electrolyte Changes During Dilution Perfusion

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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1964 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1964.01310200013003
Publisher site
See Article on Publisher Site

Abstract

Abstract The problems of extracorporeal circulation remain far from being solved, either from the biological or technical standpoints. However, a major step forward has been the introduction of the principle of hemodilution. This modality has reduced certain risks of perfusion, of which the "homologous blood syndrome"4,5 with its associated changes seem to be the most important. The main technical advantage of the method lies in its simplicity, avoiding to a considerable extent the use of homologous blood for priming the heart-lung machine. However, hemodilution violates the fundamental principle of maintenance of the constancy of the milieu interieur by rapidly altering the concentrations of the constituents of the blood. The changes in the concentrations of electrolytes and the consequent readjustments constitute a major aspect of this problem. The alterations depend on the amount and composition of the solutions used for hemodilution and of the ability of the organism to deal with References 1. Available from Travenol Laboratories, Inc., Morton Grove, Ill. 2. Beall, A. C., Jr., and Cooley, D. A.: Renal Hemodynamic Effects of Total Cardiopulmonary Bypass Eliminating Heparinized Blood , American Heart Association Monograph: No. 6, Cardiovascular Surgery 1963, p 820. 3. Cooley, D. A.; Beall, A. C.; and Grondin, P.: Open Heart Operations With Disposable Oxygenators, 5% Dextrose Prime and Normothermia , Surgery 52:713, 1962. 4. DeWall, R. A.; Lillehei, R. C.; and Sellers, R. D.: Hemodilution Perfusions for Open Heart Surgery , New Eng J Med 266:1078, 1962.Crossref 5. Gadboys, H. L.; Slonim, R.; and Litwak, R. S.: Homologous Blood Syndromes: I. Preliminary Observations on Its Relationship to Clinical Cardiopulmonary Bypass , Ann Surg 156:793, 1962.Crossref 6. Litwak, R. S.; Slonim, R.; Wisoff, B. G.; and Gadboys, H. L.: Homologous Blood Syndrome During Extracorporeal Circulation in Man: II. Phenomena of Sequestration and Desequestration , New Eng J Med 268:1377, 1963.Crossref 7. Paton, B. C.: Cardiopulmonary Bypass With Diluted Blood , J Roy Coll Surg (Edinburgh) 8: 301, 1963. 8. Sakai, Y.; Linder, E.; and Paton, B. C.: Physiologic Effects of Rapid Hemodilution by Infusion of Electrolyte Solutions, to be published. 9. Zuhdi, N.; Carey, J.; and Greer, A.: Hemodilution for Body Perfusion , J Okla Med Ass 56:88, 1963.

Journal

Archives of SurgeryAmerican Medical Association

Published: Feb 1, 1964

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