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P. Shore, A. Burkhalter, V. Cohn (1959)
A method for the fluorometric assay of histamine in tissues.The Journal of pharmacology and experimental therapeutics, 127
W. Feldberg (1953)
Release of Histamine by Tryptamine and 5-HydroxytryptamineBrit J Pharmacol, 8
A. M. Rothschild (1961)
Effect of Metabolic Inhibitors on the Release of Histamine by Anaphylatoxin and by Antigen in VitroExperientia, 17
B. Uvnäs (1961)
Mechanism of Histamine Release From Mast CellsChemotherapia (Basel), 3
T. Drapanas, J. McDonald, J. Stewart (1962)
Serotonin Release Following Instillation of Hypertonic Glucose into the Proximal Intestine.Annals of surgery, 156 4
BY Toh (1954)
Release of 5‐hydroxytryptamine (serotonin) from the dog's gastro‐intestinal tractThe Journal of Physiology, 126
G. Peskin, L. Miller (1962)
The role of serotonin in the "dumping syndrome".Archives of surgery, 85
B. Diamant, B. Uvnas (1961)
Evidence for energy-requiring processes in histamine release and mast cell degranulation in rat tissues induced by compound 48/80.Acta physiologica Scandinavica, 53
W. Paton (1958)
The release of histamine.Progress in allergy, 5
G. Kahlson (1962)
New Approaches to the Physiology of HistaminePerspect Biol Med, 5
O'hara Rs, Fox Ro, Cole Jw (1960)
Serotonin release mediated by intraluminal sucrose solutions.Surgical forum, 10
B. Westerholm (1960)
The influence of anoxia on 48/80-induced histamine release from cat skin.Acta physiologica Scandinavica, 50
A. Rothschild, I. Vugman, M. Silva (1961)
Metabolic studies on the release of histamine by compound 48/80 in the rat diaphragm.Biochemical pharmacology, 7
F. Macintosh, W. Paton (1949)
The liberation of histamine by certain organic basesThe Journal of Physiology, 109
B. Eiseman, P. Knipe, H. McColl, M. Orloff (1961)
Isolated liver perfusion for reducing blood ammonia.Archives of surgery, 83
S. E. Lindell (1961)
A Note on the Distribution of C14 Histamine Added to BloodBrit J Pharmacol, 17
E. Verney, E. Starling (1922)
On secretion by the isolated kidneyThe Journal of Physiology, 56
J. Gaddum, Catherine Hebb, Ann Silver, A. Swan (1953)
5-Hydroxytryptamine; pharmacological action and destruction in perfused lungs.Quarterly journal of experimental physiology and cognate medical sciences, 38 4
B. Pernow, J. Waldenstrom (1957)
Determination of 5-hydroxytryptamine, 5-hydroxyindole acetic acid and histamine in thirty-three cases of carcinoid tumor (argentaffinoma).The American journal of medicine, 23 1
B. Eiseman , P. Knipe, H. A. McColl, M. J. and Orloff (1961)
Isolated Liver Perfusion for Reducing Blood AmmoniaAMA Arch Surg, 83
E. Starling, E. Verney (1925)
The secretion of urine as studied on the isolated kidneyProceedings of The Royal Society B: Biological Sciences, 97
I. Page, J. Mccubbin (1956)
Arterial pressure response to infused serotonin in normotensive dogs, cats, hypertensive dogs and man.The American journal of physiology, 184 2
C. C. Toh (1954)
Release of 5-Hydroxytryptamine From the Dog's Gastrointestinal TractJ Physiol, 126
G. W. Peskin (1962)
The Role of Serotonin in the "Dumping Syndrome,"AMA Arch Surg, 85
L. Johnson, R. Sloop, J. Jesseph, H. Harkins (1962)
Serotonin antagonists in experimental and clinical "dumping'.Annals of surgery, 156
W. Feldberg, A. Smith (1953)
Release of histamine by tryptamine and 5-hydroxytryptamine.The Journal of physiology, 122 Suppl
R. D. Higginbotham (1956)
Mechanism of Heparin Protection Against a Histamine Releaser (48/80)Proc Soc Exp Biol Med, 92
W. Feldberg, W. Paton (1951)
Release of histamine from skin and muscle in the cat by opium alkaloids and other histamine liberatorsThe Journal of Physiology, 114
Abstract Considerable experimental and clinical evidence has been accumulated in recent years to indicate that a significant increase in the discharge of serotonin (5-hydroxytryptamine) into the vascular system occurs in both the postgastrectomy dumping and the metastatic carcinoid syndromes. The precise roles of the release of serotonin in the production of the physiologic changes and symptoms which occur in these syndromes is not entirely clear. The cardiac lesions which are found in the carcinoid syndrome are limited to the right side of the heart, and there is experimental evidence that serotonin is inactivated by the lung. Although experimental "dumping" is associated with a significant increase in serotonin in portal venous blood, a corresponding increase in systemic venous and arterial blood has not been demonstrated. In addition, there is evidence that serotonin is inactivated by the liver as well as the lung. The purpose of this study is to evaluate, by means References 1. Polyoxyethylene sorbitan monolaurate. 2. Diamant, B., and Uvnäs, B.: Evidence for Energy-Requiring Processes in Histamine Release and Mast Cell Degranulation in Rat Tissues Induced by Compound 48/80 , Acta Physiol Scand 53: 315, 1961.Crossref 3. Drapanas, T.; McDonald, J. C.; and Stewart, J. D.: Serotonin Release Following Instillation of Hypertonic Glucose Into the Proximal Intestine , Ann Surg 156:528, 1962.Crossref 4. Drapanas, T.: Personal communication to the author. 5. Eiseman, B.; Knipe, P.; McColl, H. A.; and Orloff, M. J.: Isolated Liver Perfusion for Reducing Blood Ammonia , AMA Arch Surg 83:356, 1961.Crossref 6. Feldberg, W., and Paton, W. D. M.: Release of Histamine From Skin and Muscle in the Cat by Opium Alkaloids and Other Histamine Liberators , J Physiol 114:490, 1951. 7. Feldberg, W., and Smith, A. N.: Release of Histamine by Tryptamine and 5-Hydroxytryptamine , Brit J Pharmacol 8:406, 1953. 8. Gaddum, J. H.; Hebb, C. O.; Silver, A.; and Swan, A. A. B.: 5-Hydroxytryptamine: Pharmacologic Action and Destruction in Perfused Lungs , Quart J Exp Physiol 38:255, 1953. 9. Higginbotham, R. D., and Dougherty, T. F.: Mechanism of Heparin Protection Against a Histamine Releaser (48/80) , Proc Soc Exp Biol Med 92:493, 1956.Crossref 10. Johnson, L. P.; Sloop, R. D.; Jesseph, J. E.; and Harkins, H. N.: Serotonin Antagonists in Experimental and Clinical "Dumping," Ann Surg 156: 537, 1962.Crossref 11. Kahlson, G.: New Approaches to the Physiology of Histamine , Perspect Biol Med 5:179, 1962. 12. Lindell, S. E., and Viske, K.: A Note on the Distribution of C14 Histamine Added to Blood , Brit J Pharmacol 17:131, 1961. 13. MacIntosh, F. C., and Paton, W. D. M.: The Liberation of Histamine by Certain Inorganic Bases , J Physiol 109:190, 1949. 14. O'Hara, R. S.; Fox, R. D.; and Cole, J. W.: Serotonin Release Mediated by Intraluminal Sucrose Solutions , Surg Forum 10:215, 1959. 15. Page, I. H., and McCubbin, J. W.: Arterial Pressure Response to Infused Serotonin in Normotensive Dogs, Cats, Hypertensive Dogs and Man , Amer J Physiol 184:265, 1956. 16. Paton, W. D. M.: The Release of Histamine , Progr Allerg 5:79, 1958. 17. Pernow, B., and Waldenström, J.: Determination of 5-Hydroxytryptamine, 5-Hydroxyindole Acetic Acid and Histamine in 33 Cases of Carcinoid Tumor (Argentaffinoma) , Amer J Med 23:16, 1957.Crossref 18. Peskin, G. W., and Miller, L. D.: The Role of Serotonin in the "Dumping Syndrome," AMA Arch Surg 85:701, 1962.Crossref 19. Rothschild, A. M.: Effect of Metabolic Inhibitors on the Release of Histamine by Anaphylatoxin and by Antigen in Vitro , Experientia 17:555, 1961.Crossref 20. Rothschild, A. M.; Vugman, I.; and Rocha e Silva, M.: Metabolic Studies on the Release of Histamine by Compound 48/80 in the Rat Diaphragm , Biochem Pharmacol 7:248, 1961.Crossref 21. Shore, P. A.; Burkhalter, A.; and Cohn, V. H., Jr.: A Method for the Fluorometric Assay of Histamine in Tissues , J Pharmacol Exp Ther 127:182, 1959. 22. Starling, E. H., and Verney, E. B.: The Secretion of Urine as Studied on the Isolated Kidney , Proc Royal Soc [Biol] 97:321, 1925.Crossref 23. Toh, C. C.: Release of 5-Hydroxytryptamine From the Dog's Gastrointestinal Tract , J Physiol 126:248, 1954. 24. Uvnäs, B.: Mechanism of Histamine Release From Mast Cells , Chemotherapia (Basel) 3:137, 1961.Crossref 25. Verney, E. B., and Starling, E. H.: Secretion by the Isolated Kidney , J Physiol 56:353, 1922. 26. Westerholm, B.: The Influence of Anoxia on 48/80-Induced Histamine Release From Rat Skin , Acta Physiol Scand 50:300, 1960.Crossref
Archives of Surgery – American Medical Association
Published: Jul 1, 1963
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