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M. Trede, B. Chir., A. Foote, J. Maloney (1961)
Pathophysiologic aspects of profound hypothermia with extracorporeal circulation.Annals of surgery, 154
Taylor Dg, Cavanagh Jb (1958)
Cerebral complications following experimental extracorporeal circulation.Guy's Hospital reports, 107
J. L. Ehrenhaft , M. A. Claman, J. M. Layton (1961)
Cerebral Complications of Open-Heart Surgery: Further ObservationsJ Thor. Cardiov. Surg., 42
W. Overbeck , G. Richter, K. Wiemers, E. G. Kaniak, G. Feifel, C. H. Schweikert (1961)
Tierexperimentelle Untersuchungen zur Kombination des extrakorporalen Kreislaufs mit tiefer Hypothermie, LangenbeckArch. Klin. Chir., 297
D. Lindberg, F. Lucas, J. Sheagren, J. Malm (1961)
Silicone embolization during clinical and experimental heart surgery employing a bubble oxygenator.The American journal of pathology, 39
W. Smith (1960)
Cerebral lesions due to emboli of silicone anti-foam in dogs subjected to cardiopulmonary bypass.The Journal of pathology and bacteriology, 80
V. O. Bjork (1961)
The Oxygen Consumption in Man Under Deep Hypothermia and the Safe Period of Circulatory ArrestJ. Thor. Cardiov. Surg., 42
A. Juvenelle, J. Lind, C. Wegelius (1954)
A new method of extracorporeal circulation: deep hypothermia combined with artificial circulation.American heart journal, 47 5
G. Melcher, W. Walcott (1951)
Myocardial changes following shock.The American journal of physiology, 164 3
Abstract The large numbers of patients who have successfully undergone surgery utilizing various combinations of extracorporeal circulation and hypothermia testify to the efficacy of the combination of these techniques. The addition of hypothermia has led to lowered tissue metabolic demands, and thus, perfusion at relatively low flows or circulatory arrest has seemed practical. However, recent clinical reports1,2 and experimental studies3-5 suggest that hypothermia may not provide as large a margin of safety in preventing tissue damage when low-flow perfusion or circulatory arrest are used as had been previously hoped. Recently Brown et al. reported their experience with combined deep hypothermia and extracorporeal circulation in dogs. These authors were particularly interested in the neurologic status and pathologic findings in dogs surviving perfusion. It was noted that a majority of dogs who survived low-flow perfusion with deep hypothermia developed a characteristic neurologic syndrome. The major features were hind leg weakness or References 1. Electronics for Medicine, Inc., White Plains, N.J. 2. Angio-CONRAY or Ditriokon was kindly supplied by Mr. James A. Peterson of the Mallinckrodt Chemical Works, St. Louis. 3. Fluorescite, C. F. Kirk Company, New York. 4. Bjork, V. O., and Holmdahl, M. H.: The Oxygen Consumption in Man Under Deep Hypothermia and the Safe Period of Circulatory Arrest , J. Thor. Cardiov. Surg. 42:392, 1961. 5. Ehrenhaft, J. L.; Claman, M. A.; Layton, J. M., and Zimmerman, G. R.: Cerebral Complications of Open-Heart Surgery: Further Observations , J Thor. Cardiov. Surg. 42:514, 1961. 6. Brown, I. W., Jr.; Yerasimedes, T. G.; Smith, W. W.; Margolis, G.; Robbins, T. W., Jr., and Ewy, H. G.: The Pathology of Experimental Extracorporeal Circulation and Perfusion Hypothermia, presented at the International Cardiovascular Society, Dublin, Ireland, September, 1961, to be published. 7. Overbeck, W.; Richter, G.; Wiemers, K.; Kaniak, E. G.; Feifel, G.; Schweikert, C. H., and Sickinger, K.: Tierexperimentelle Untersuchungen zur Kombination des extrakorporalen Kreislaufs mit tiefer Hypothermie, Langenbeck , Arch. Klin. Chir. 297:378, 1961. 8. Trede, M.; Chir., B.; Foote, A. V., and Maloney, J. V., Jr.: Pathophysiologic Aspects of Profound Hypothermia with Extracorporeal Circulation , Ann. Surg. 154:210, 1961.Crossref 9. Melcher, G. W., Jr., and Walcott, W. W.: Myocardial Changes Following Shock , Amer. J. Physiol , 164:832, 1951. 10. Taylor, D. G., and Cavanagh, J. B.: Cerebral Complications Following Experimental Extracorporeal Circulation , Guy. Hosp. Rep. 107:207, 1958. 11. Smith, W. T.: Cerebral Lesions Due to Emboli of Silicone Anti-Foam in Dogs Subjected to Cardiopulmonary Bypass , J. Path. Bact. 80: 9, 1960.Crossref 12. Lindberg, D. A. B.; Lucas, F. V.; Sheagren, J., and Malm, J. R.: Silicone Embolization During Clinical and Experimental Heart Surgery Employing a Bubble Oxygenator , Amer. J. Path. 39:129, 1961. 13. Juvenelle, A. A.; Lind, T., and Wegelius, C.: A New Method of Extracorporeal Circulation: Deep Hypothermia Combined with Artificial Circulation , Amer. Heart J. 47:692, 1954.Crossref
Archives of Surgery – American Medical Association
Published: Jan 1, 1963
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