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Ulcer Formation After Duodenal Transplantation: Experimental Studies

Ulcer Formation After Duodenal Transplantation: Experimental Studies Abstract The occurrence of duodenal and gastric ulceration in dogs when a segment of duodenum containing the bile and pancreatic ducts was transplanted to the terminal ileum was reported in 1953. The interposition of the duodenal segment in the midportion of the small intestine was not associated with the development of ulceration.1,2 Later studies indicated that acid secretion, as measured by Heidenhain pouches, was similar in the 2 preparations.5 Dragstedt and his associates4 who studied the mechanism of the development of the Exalto-Mann-Williamson ulcer suggested that the failure of the development of ulcerations in the preparation in which the duodenal segment was interposed in the jejunum was due to the protective action of regurgitated duodenal juices. Our study was undertaken to test this hypothesis. Methods Adult mongrel dogs were used. The initial stage of the experiment was the isolation of a segment of the duodenum which contained the References 1. Keefer, E. B. C.; Martin, K. A., and Glenn, F.: A New Method of Producing Duodenal and Gastric Ulcers in Dogs , Surg. Forum 4:330, 1953. 2. Keefer, E. B. C.; Hays, D. M.; Martin, K. A.; Beal, J. M., and Glenn, F.: Further Studies of Experimental Gastric and Duodenal Ulcers in Dogs , Surg. Forum 5:288, 1954. 3. Matthews, W. B., and Dragstedt, L. R.: The Etiology of Gastric and Duodenal Ulcer: Experimental Studies , Surg. Gynec. Obstet. 15:265, 1932. 4. Nagano, K.; Johnson, A. N., Jr.; Dragstedt, L. R., II; Oberhelman, H. A., Jr.; Cobo, A., and Dragstedt, L. R.: The Pathogenesis of the Exalto-Mann-Williamson Ulcer: I. The Significance of the Neutralizing and Buffering Effect of the Duodenal Secretions , Gastroenterology 39:319, 1960. 5. Okinaka, A.; Moody, F.; Dineen, J.; Beal, J. M., and Martin, K. A.: Experimental Production of Peptic Ulcers Without Increased Secretion of Acid , Surgery 46:70, 1959. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Ulcer Formation After Duodenal Transplantation: Experimental Studies

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References (5)

Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1962.01310060164031
Publisher site
See Article on Publisher Site

Abstract

Abstract The occurrence of duodenal and gastric ulceration in dogs when a segment of duodenum containing the bile and pancreatic ducts was transplanted to the terminal ileum was reported in 1953. The interposition of the duodenal segment in the midportion of the small intestine was not associated with the development of ulceration.1,2 Later studies indicated that acid secretion, as measured by Heidenhain pouches, was similar in the 2 preparations.5 Dragstedt and his associates4 who studied the mechanism of the development of the Exalto-Mann-Williamson ulcer suggested that the failure of the development of ulcerations in the preparation in which the duodenal segment was interposed in the jejunum was due to the protective action of regurgitated duodenal juices. Our study was undertaken to test this hypothesis. Methods Adult mongrel dogs were used. The initial stage of the experiment was the isolation of a segment of the duodenum which contained the References 1. Keefer, E. B. C.; Martin, K. A., and Glenn, F.: A New Method of Producing Duodenal and Gastric Ulcers in Dogs , Surg. Forum 4:330, 1953. 2. Keefer, E. B. C.; Hays, D. M.; Martin, K. A.; Beal, J. M., and Glenn, F.: Further Studies of Experimental Gastric and Duodenal Ulcers in Dogs , Surg. Forum 5:288, 1954. 3. Matthews, W. B., and Dragstedt, L. R.: The Etiology of Gastric and Duodenal Ulcer: Experimental Studies , Surg. Gynec. Obstet. 15:265, 1932. 4. Nagano, K.; Johnson, A. N., Jr.; Dragstedt, L. R., II; Oberhelman, H. A., Jr.; Cobo, A., and Dragstedt, L. R.: The Pathogenesis of the Exalto-Mann-Williamson Ulcer: I. The Significance of the Neutralizing and Buffering Effect of the Duodenal Secretions , Gastroenterology 39:319, 1960. 5. Okinaka, A.; Moody, F.; Dineen, J.; Beal, J. M., and Martin, K. A.: Experimental Production of Peptic Ulcers Without Increased Secretion of Acid , Surgery 46:70, 1959.

Journal

Archives of SurgeryAmerican Medical Association

Published: Dec 1, 1962

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