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K. Nagano, A. Johnson, I. Dragstedtlr, H. Oberhelman, A. Cobo, L. Dragstedt (1960)
The pathogenesis of the Exalto-Mann-Williamson ulcer. 1. The significance of the neutralizing and buffering effect of the duodenal secretions.Gastroenterology, 39
A. Okinaka, F. Moody, J. Dineen, J. Beal, K. Martin (1959)
Experimental production of peptic ulcers without increased secretion of acid.Surgery, 46 1
W. B. Matthews (1932)
The Etiology of Gastric and Duodenal Ulcer: Experimental StudiesSurg. Gynec. Obstet., 15
Keefe Eb, Martinez Ka, F. Glenn (1953)
A new method of producing duodenal and gastric ulcers in dogs.Surgical forum, 4
E. Keefer, Hays Dm, Martinez Ka, J. Beal, F. Glenn (1955)
Further studies of experimental gastric and duodenal ulcers in dogs.Surgical forum, 5
Abstract The occurrence of duodenal and gastric ulceration in dogs when a segment of duodenum containing the bile and pancreatic ducts was transplanted to the terminal ileum was reported in 1953. The interposition of the duodenal segment in the midportion of the small intestine was not associated with the development of ulceration.1,2 Later studies indicated that acid secretion, as measured by Heidenhain pouches, was similar in the 2 preparations.5 Dragstedt and his associates4 who studied the mechanism of the development of the Exalto-Mann-Williamson ulcer suggested that the failure of the development of ulcerations in the preparation in which the duodenal segment was interposed in the jejunum was due to the protective action of regurgitated duodenal juices. Our study was undertaken to test this hypothesis. Methods Adult mongrel dogs were used. The initial stage of the experiment was the isolation of a segment of the duodenum which contained the References 1. Keefer, E. B. C.; Martin, K. A., and Glenn, F.: A New Method of Producing Duodenal and Gastric Ulcers in Dogs , Surg. Forum 4:330, 1953. 2. Keefer, E. B. C.; Hays, D. M.; Martin, K. A.; Beal, J. M., and Glenn, F.: Further Studies of Experimental Gastric and Duodenal Ulcers in Dogs , Surg. Forum 5:288, 1954. 3. Matthews, W. B., and Dragstedt, L. R.: The Etiology of Gastric and Duodenal Ulcer: Experimental Studies , Surg. Gynec. Obstet. 15:265, 1932. 4. Nagano, K.; Johnson, A. N., Jr.; Dragstedt, L. R., II; Oberhelman, H. A., Jr.; Cobo, A., and Dragstedt, L. R.: The Pathogenesis of the Exalto-Mann-Williamson Ulcer: I. The Significance of the Neutralizing and Buffering Effect of the Duodenal Secretions , Gastroenterology 39:319, 1960. 5. Okinaka, A.; Moody, F.; Dineen, J.; Beal, J. M., and Martin, K. A.: Experimental Production of Peptic Ulcers Without Increased Secretion of Acid , Surgery 46:70, 1959.
Archives of Surgery – American Medical Association
Published: Dec 1, 1962
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