Access the full text.
Sign up today, get DeepDyve free for 14 days.
Orris Leo, L. Benjamin, I. Alvin, Nelson Norton, F. Schmitt (1958)
The carcinogenicity for mouse skin and the aromatic hydrocarbon content of cigarette-smoke condensates.Journal of the National Cancer Institute, 21
A. H. Roffo (1930)
Leukoplasia Tobaquica ExperimentalRev. Sud-Amer. Med. Chir., 1
H. Liang (1948)
Localized changes in methylcholanthrene-treated epidermis.Cancer research, 8 5
A. Gellhorn (1958)
The cocarcinogenic activity of cigarette tobacco tar.Cancer research, 18 5
C. Moore, A. Miller (1958)
Effect of cigarette smoke tar on the hamster pouch.A.M.A. archives of surgery, 76 5
K. Setala, L. Merenmies, L. Stjernvall, Y. Aho, P. Kajanne (1959)
Mechanism of experimental tumorigenesis. I. Epidermal hyperplasia in mouse caused by locally applied tumor initiator and dipoletype tumor promotor.Journal of the National Cancer Institute, 23
F. Bock, G. Moore (1959)
Carcinogenic activity of cigarette-smoke condensate. I. Effect of trauma and remote x irradiation.Journal of the National Cancer Institute, 22 2
E. Rockey, M. Kuschner, A. Kosak, E. Mayer (1958)
The effect of tobacco tar on the bronchial mucosa of dogsCancer, 11
R. Leuchtenberger, C. Leuchtenberger, W. Zebrun, Patricia Shaffer (1960)
A correlated histological, cytological, and cytochemical study of the tracheobronchial tree and lungs of mice exposed to cigarette smoke. III. Unaltered incidence of grossly visible adenomatous lung tumors in female CF1 mice after prolonged exposure to cigarette smokeCancer, 13
E. Wynder, D. Hoffmann (1959)
A study of tobacco carcinogenesis. VII. The role of higher polycyclic hydrocarbonsCancer, 12
V. Suntzeff, C. Carruthers, E. Cowdry (1947)
The Role of Sebaceous Glands and Hair Follicles in Epidermal CarcinogenesisCancer Research, 7
C. Leuchtenberger, R. Leuchtenberger, P. Doolin, Patricia Shaffer (1958)
A correlated histological, cytological, and cytochemical study of the tracheobronchial tree and lungs of mice exposed to cigarette smoke. I. Bronchitis with atypical epithelial changes in mice exposed to cigarette smokeCancer, 11
C. Hiebert (1959)
The carcinogenic action of methylcholanthrene on mouse skin in organ cultureCancer, 12
Van Duuren, L. Benjamin (1958)
The Polynuclear Aromatic Hydrocarbons in Cigarette-Smoke Condensate. IIJournal of the National Cancer Institute, 21
J. DiPaolo, G. Moore (1959)
Effect on mice of oral painting of cigarette-smoke condensate.Journal of the National Cancer Institute, 23
E. Peacock, B. Greenberg, B. Brawley (1960)
The effect of snuff and tobacco on the production of oral carcinoma: an experimental and epidemiological study.Annals of surgery, 151
P. Kotin, H. Falk (1960)
The role and action of environmental agents in the pathogenesis of lung cancer. II. Cigarette smokeCancer, 13
Philippe Shubik, Giuseppe Pietra, G. Porta (1960)
Studies of skin carcinogenesis in the Syrian golden hamster.Cancer research, 20
C. Leuchtenberger , R. Leuchtenberger (1958)
A Correlated Histological, Cytological and Cytochemical Study of the Tracheobronchial Tree and Lungs of Mice Exposed to Cigarette SmokeCancer, 11
E. Wynder, I. Bross, Rivkah Feldman (1957)
A study of the etiological factors in cancer of the mouthCancer, 10
L. Holsti, P. Ermala (1955)
Papillary carcinoma of the bladder in mice, obtained after peroral administration of tobacco tarCancer, 8
J. Salley (1957)
Histologic Changes in the Hamster Cheek Pouch During Early Hydrocarbon CarcinogenesisJournal of Dental Research, 36
E. Wynder, E. Graham, A. Croninger (1953)
Experimental production of carcinoma with cigarette tar.Cancer research, 13 12
E. V. Cowdry (1955)
Cancer Cells
M. Guerin (1959)
Pulmonary Tumours and Buccal Cancer in Rats Subjected to Inhalation of Cigarette-SmokeBull. Ass. Franc. Cancer, 46
I. Koprowska (1959)
A Cytopathologic Study of Tobacco Tar-Induced Lesions of the Uterine Cervix of the MouseJ. Nat. Cancer Inst., 23
V. Suntzeff, V. Suntzeff, A. Croninger, A. Croninger, E. Wynder, E. Wynder, E. Cowdry, E. Cowdry, E. Graham, E. Graham (1957)
Use of sebaceous‐gland test of primary cigarette‐tar fractions and of certain noncarcinogenic polycyclic hydrocarbonsCancer, 10
Abstract Cigarette-smoke condensate, usually combined with a solvent such as acetone, reportedly produces various changes when applied to animal tissues. These changes cover a wide range from mild hyperplasia to gross, metastasizing cancer. Tissues so far studied include skin, oral mucosa, bronchial mucosa, epithelium of bladder, and uterine cervix.3,7,8,10,24 Most studies have been in mice, a few in hamsters, rabbits, and rats. Histologic cancer from the condensate has been reported in skin, bladder, cervix, and mouth.4,7,8,24 Of the 18 or more polycyclic hydrocarbons22 identified in the condensate, 8 are reported to be carcinogenic for animals.25 While some investigators emphasize that concentrations of carcinogenic hydrocarbons in the condensate (predominately benzo[a]pyrene) are not sufficient to justify rating cigarettes as a major factor in human cancer,9 others feel that the complexity of the condensate, varying with different conditions of combustion in its production and containing multiple carcinogens References 1. Purchased from Eastman Organic Chemicals, Rochester, N.Y. 2. Bock, F. G., and Moore, G. E.: Carcinogenic Activity of Cigarette-Smoke Condensate: I. Effect of Trauma and Remote X-Irradiation , J. Nat. Cancer Inst. 22:401, 1959. 3. Cowdry, E. V.: Cancer Cells , Philadelphia, W. B. Saunders Company, 1955, p. 326. 4. Dipaolo, J. A., and Moore, G. E.: Effect on Mice of Oral Painting of Cigarette-Smoke Condensate , J. Nat. Cancer Inst. 23:529, 1959. 5. Guerin, M.: Pulmonary Tumours and Buccal Cancer in Rats Subjected to Inhalation of Cigarette-Smoke , Bull. Ass. Franc. Cancer 46: 295, 1959. 6. Gellhorn, A.: The Cocarcinogenic Activity of Cigarette Tobacco Tar , Cancer Res. 18:510, 1958. 7. Hiebert, C. A.: The Carcinogenic Action of Methylcholanthrene on Mouse Skin in Organ Culture , Cancer 12:663, 1959.Crossref 8. Holsti, L. R., and Ermala, P.: Papillary Carcinoma of the Bladder in Mice Obtained After Peroral Administration of Tobacco Tar , Cancer 8:679, 1955.Crossref 9. Koprowska, I., and Bogacz, J.: A Cytopathologic Study of Tobacco Tar-Induced Lesions of the Uterine Cervix of the Mouse , J. Nat. Cancer Inst. 23:1, 1959. 10. Kotin, P., and Falk, H. L.: The Role and Action of Environmental Agents in the Pathogenesis of Lung Cancer: II. Cigarette Smoke , Cancer 13:250, 1960.Crossref 11. Leuchtenberger, C.; Leuchtenberger, R., and Doolin, P. F.: A Correlated Histological, Cytological and Cytochemical Study of the Tracheobronchial Tree and Lungs of Mice Exposed to Cigarette Smoke , Cancer 11:490, 1958.Crossref 12. Liang, H. M.: Localized Changes in Methylcholanthrene Treated Epidermis , Cancer Res. 8: 211, 1948. 13. Moore, C., and Miller, A. J.: Effect of Cigarette Smoke Tar on the Hamster Pouch , A.M.A. Arch. Surg. 76:786, 1958.Crossref 14. Orris, L.; Van Duuren, B. L.; Kosak, A. I.; Nelson, N., and Schmitt, F. L.: The Carcinogenicity for Mouse Skin and the Aromatic Hydrocarbon Content of Cigarette-Smoke Condensates , J. Nat. Cancer Inst. 21:557, 1958. 15. Peacock, E. E., Jr.; Greenberg, B. G., and Brawley, B. W.: The Effect of Snuff and Tobacco on the Production of Oral Carcinoma: An Experimental and Epidemiological Study , Ann. Surg. 151:542, 1960.Crossref 16. Rockey, E. E.; Kuschner, M.; Kosak, A. I., and Mayer, E.: The Effect of Tobacco Tar on the Bronchial Mucosa of Dogs , Cancer 11:466, 1958.Crossref 17. Roffo, A. H.: Leukoplasia Tobaquica Experimental , Rev. Sud-Amer. Med. Chir. 1:321, 1930. 18. Salley, J. J.: Histologic Changes in the Hamster Cheek Pouch During Early Hydrocarbon Carcinogenesis , J. Dent. Res. 36:48, 1957.Crossref 19. Setala, K.; Merenmies, L.; Stjernvall, L.; Aho, Y., and Kajanne, P.: Mechanism of Experimental Tumorigenesis: I. Epidermal Hyperplasia in Mouse Caused by Locally Applied Tumor Initiator and Dipole-Type Tumor Promotor , J. Nat. Cancer Inst. 23:925, 1959. 20. Shubik, P.; Pietra, G., and Della Porta, G.: Studies of Skin Carcinogenesis in the Syrian Golden Hamster , Cancer Res. 20:100, 1960. 21. Suntzeff, V.; Carruthers, C., and Cowdry, E. V.: Role of Sebaceous Glands and Hair Follicles in Epidermal Carcinogenesis , Cancer Res. 7:439, 1947. 22. Suntzeff, V.; Croninger, A. B.; Wynder, E. L.; Cowdry, E. V., and Graham, E. A.: Use of Sebaceous-Gland Test of Primary Cigarette-Tar Fractions and of Certain Noncarcinogenic Polycyclic Hydrocarbons , Cancer 10:250, 1957.Crossref 23. Van Duuren, B. L.: The Polynuclear Aromatic Hydrocarbons in Cigarette-Smoke Condensate: II . J. Nat. Cancer Inst. 21:623, 1958. 24. Wynder, E. L.; Bross, I. J., and Feldman, R. M.: A Study of the Etiological Factors in Cancer of the Mouth , Cancer 10:1300, 1957.Crossref 25. Wynder, E. L.; Graham, E. A., and Croninger, A. B.: Experimental Production of Carcinoma with Cigarette Tar , Cancer Res. 13:855, 1953. 26. Wynder, E. L., and Hoffmann, D.: A Study of Tobacco Carcinogenesis: VII. The Role of Higher Polycyclic Hydrocarbons , Cancer 12:1079, 1959.Crossref
Archives of Surgery – American Medical Association
Published: Apr 1, 1962
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.