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New Types of Cytotoxic Colloids for Cancer Therapy

New Types of Cytotoxic Colloids for Cancer Therapy Abstract Cytotoxic colloids such as radioactive gold and chromium phosphate have shown limited usefulness for clinical cancer therapy. In their favor is the fact that isotopes of suitable decay characteristics have been chosen to make their clinical use practical. Also, the transport characteristics of presently used colloids are relatively good. Thus, if radioactive gold or chromium phosphate is instilled into the peritoneal or pleural cavity, most of the colloid stays in the cavity where colloid is instilled. The localization pattern of all colloids used to date, however, has seriously hampered their usefulness. Colloids, radioactive or not, share a common distribution in the body. They concentrate in normal tissue and in the normal portions of lymph nodes. Specifically, colloids are not taken up by tumor tissue or by that part of nodes replaced by tumor.1,2 For clinical usefulness in destroying cancer a localization pattern is needed which is the exact opposite References 1. Lahr, T. N.; Olsen, R.; Gleason, G. I., and Tabern, D. L.: Animal Distribution of Colloids of Au-198, P-32 and Y-90; An Improved Method of Tissue Assay for Radioactivity , J. Lab. Clin. Med. 45:66-80, 1955. 2. Gilchrist, R. K.; Medal, R.; Shorey, W. D.; Hanselman, R. C.; Parrott, J. C., and Taylor, C. B.: Selective Inductive Heating of Lymph Nodes , Ann. Surg. 146:596-606, 1957.Crossref 3. Knock, F. E.: Perfusion of Uranium-Antibody Complexes for the Neutron Capture Therapy of Tumors , Surg. Gynec. Obstet. 109:445-449, 1959. 4. Knock, F. E.: Perfusion of Chemically Modified Antibodies for the Therapy of Cancer , Surg. Gynec. Obstet. 111:322-328, 1960. 5. Knock, F. E.: Disposable Pump Oxygenator for Perfusion in Small Animals , Arch. Surg. 81: 668-670, 1960.Crossref 6. Day, E. D.; Barnes, G. W.; Planinsek, J. A., and Pressman, D.: Improved Methods for the Purification of Tumor-Localizing Antibodies , J. Nat. Canc. Inst. 20:1123-1139, 1958. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

New Types of Cytotoxic Colloids for Cancer Therapy

KNOCK, FRANCES E.
Archives of Surgery , Volume 83 (6) – Dec 1, 1961
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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1961.01300180090017
Publisher site
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Abstract

Abstract Cytotoxic colloids such as radioactive gold and chromium phosphate have shown limited usefulness for clinical cancer therapy. In their favor is the fact that isotopes of suitable decay characteristics have been chosen to make their clinical use practical. Also, the transport characteristics of presently used colloids are relatively good. Thus, if radioactive gold or chromium phosphate is instilled into the peritoneal or pleural cavity, most of the colloid stays in the cavity where colloid is instilled. The localization pattern of all colloids used to date, however, has seriously hampered their usefulness. Colloids, radioactive or not, share a common distribution in the body. They concentrate in normal tissue and in the normal portions of lymph nodes. Specifically, colloids are not taken up by tumor tissue or by that part of nodes replaced by tumor.1,2 For clinical usefulness in destroying cancer a localization pattern is needed which is the exact opposite References 1. Lahr, T. N.; Olsen, R.; Gleason, G. I., and Tabern, D. L.: Animal Distribution of Colloids of Au-198, P-32 and Y-90; An Improved Method of Tissue Assay for Radioactivity , J. Lab. Clin. Med. 45:66-80, 1955. 2. Gilchrist, R. K.; Medal, R.; Shorey, W. D.; Hanselman, R. C.; Parrott, J. C., and Taylor, C. B.: Selective Inductive Heating of Lymph Nodes , Ann. Surg. 146:596-606, 1957.Crossref 3. Knock, F. E.: Perfusion of Uranium-Antibody Complexes for the Neutron Capture Therapy of Tumors , Surg. Gynec. Obstet. 109:445-449, 1959. 4. Knock, F. E.: Perfusion of Chemically Modified Antibodies for the Therapy of Cancer , Surg. Gynec. Obstet. 111:322-328, 1960. 5. Knock, F. E.: Disposable Pump Oxygenator for Perfusion in Small Animals , Arch. Surg. 81: 668-670, 1960.Crossref 6. Day, E. D.; Barnes, G. W.; Planinsek, J. A., and Pressman, D.: Improved Methods for the Purification of Tumor-Localizing Antibodies , J. Nat. Canc. Inst. 20:1123-1139, 1958.

Journal

Archives of Surgery – American Medical Association

Published: Dec 1, 1961

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