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Pseudomembranous Enterocolitis: The Experimental Induction of the Disease with Staphylococcus Aureus and Its Enterotoxin

Pseudomembranous Enterocolitis: The Experimental Induction of the Disease with Staphylococcus... Abstract The objection to Staphylococcus var. aureus (Micrococcus pyogenes) as the etiologic agent of pseudomembranous enteritis stems from the observation that Staphylococcus has not been isolated in every case of the disease and from the assumption that the physical changes observed in the intestine are secondary to the associated shock. These objections are without foundation. S. aureus does not grow out on every culture medium. In a mixed flora it fails to grow out at all, unless the culture medium favors its growth and suppresses the competing micro-organism. Referring physicians have told me repeatedly that the stool cultures of their patients, desperately sick with pseudomembranous enterocolitis, did not grow out staphylococci. Upon culturing the stools of these patients on proper media the staphylococci grew out in dominant Proportions. The oral administration of staphylococci to monkeys, animals highly sensitive to the enterotoxin, does not make them sick and does not induce stools References 1. Prohaska, J. V.; Long, E. T., and Nelsen, T. S.: Pseudomembranous Enterocolitis; Its Etiology and the Mechanism of the Disease Process , A. M. A. Arch. Surg. 72:977-983 ( (June) ) 1956.Crossref 2. McKay, D. G.; Hardaway, R. M., III; Wahle, G. H., and Hall, R. M.: Experimental Pseudomembranous Enterocolitis: Production by Means of Thrombosis of Intestinal Mucosal Capillaries , A. M. A. Arch. Int. Med. 95:779-787 ( (June) ) 1955.Crossref 3. Bennett, I. L., Jr.; Wood, J. S., Jr., and Yardley, J. H.: Staphylococcal Pseudomembranous Enterocolitis in Chinchillas: A ClinicoPathologic Study , Tr. A. Am. Physicians , 69:116-121, 1956. 4. Surgalla, M. J.; Bergdoll, M. S., and Dack, G. M.: Some Observations on the Assay of Staphylococcal Enterotoxin by the Monkey-Feeding Test , J. Lab. & Clin. Med. 41:782-788, ( (May) ) 1953. 5. Woolpert, O. C., and Dack, G. M.: Relation of Gastro-Intestinal Poison to Other Toxic Substances Produced by Staphylococci , J. Infect. Dis. 52:6-19 ( (Jan.-Feb.) ) 1933. 6. Oudin, J.: Specific Precipitation in Gels and Its Application to Immunochemical Analysis , in Methods in Medical Research , Vol. 5, edited by A. C. Corcoran, Chicago, The Year Book Publishers, Inc., 1952. 7. Zebovitz, E.; Evans, J. B., and Niven, C. F., Jr.: Tellurite-Glycine Agar: A Selective Plating Medium for the Quantitative Detection of Coagulase-Positive Staphylococci , J. Bact. 70:686-690 ( (Dec.) ) 1955. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives Surgery American Medical Association

Pseudomembranous Enterocolitis: The Experimental Induction of the Disease with Staphylococcus Aureus and Its Enterotoxin

A.M.A. Archives Surgery , Volume 79 (2) – Aug 1, 1959

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References (9)

Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-6908
DOI
10.1001/archsurg.1959.04320080033005
Publisher site
See Article on Publisher Site

Abstract

Abstract The objection to Staphylococcus var. aureus (Micrococcus pyogenes) as the etiologic agent of pseudomembranous enteritis stems from the observation that Staphylococcus has not been isolated in every case of the disease and from the assumption that the physical changes observed in the intestine are secondary to the associated shock. These objections are without foundation. S. aureus does not grow out on every culture medium. In a mixed flora it fails to grow out at all, unless the culture medium favors its growth and suppresses the competing micro-organism. Referring physicians have told me repeatedly that the stool cultures of their patients, desperately sick with pseudomembranous enterocolitis, did not grow out staphylococci. Upon culturing the stools of these patients on proper media the staphylococci grew out in dominant Proportions. The oral administration of staphylococci to monkeys, animals highly sensitive to the enterotoxin, does not make them sick and does not induce stools References 1. Prohaska, J. V.; Long, E. T., and Nelsen, T. S.: Pseudomembranous Enterocolitis; Its Etiology and the Mechanism of the Disease Process , A. M. A. Arch. Surg. 72:977-983 ( (June) ) 1956.Crossref 2. McKay, D. G.; Hardaway, R. M., III; Wahle, G. H., and Hall, R. M.: Experimental Pseudomembranous Enterocolitis: Production by Means of Thrombosis of Intestinal Mucosal Capillaries , A. M. A. Arch. Int. Med. 95:779-787 ( (June) ) 1955.Crossref 3. Bennett, I. L., Jr.; Wood, J. S., Jr., and Yardley, J. H.: Staphylococcal Pseudomembranous Enterocolitis in Chinchillas: A ClinicoPathologic Study , Tr. A. Am. Physicians , 69:116-121, 1956. 4. Surgalla, M. J.; Bergdoll, M. S., and Dack, G. M.: Some Observations on the Assay of Staphylococcal Enterotoxin by the Monkey-Feeding Test , J. Lab. & Clin. Med. 41:782-788, ( (May) ) 1953. 5. Woolpert, O. C., and Dack, G. M.: Relation of Gastro-Intestinal Poison to Other Toxic Substances Produced by Staphylococci , J. Infect. Dis. 52:6-19 ( (Jan.-Feb.) ) 1933. 6. Oudin, J.: Specific Precipitation in Gels and Its Application to Immunochemical Analysis , in Methods in Medical Research , Vol. 5, edited by A. C. Corcoran, Chicago, The Year Book Publishers, Inc., 1952. 7. Zebovitz, E.; Evans, J. B., and Niven, C. F., Jr.: Tellurite-Glycine Agar: A Selective Plating Medium for the Quantitative Detection of Coagulase-Positive Staphylococci , J. Bact. 70:686-690 ( (Dec.) ) 1955.

Journal

A.M.A. Archives SurgeryAmerican Medical Association

Published: Aug 1, 1959

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