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Vascular Dissemination of Cancer in Children

Vascular Dissemination of Cancer in Children Abstract Although it is generally believed that malignant tumors in children are associated with a poorer prognosis than are malignancies in adults, the reasons for such an assumption, other than clinical observation, have not been made clear. Vascular dissemination of cancer in children may be of importance in this regard. This study is concerned with that aspect of the vascular dissemination dealing with the carriage of cancer cells in the circulating blood of children, and the occurrence of these cells during an operative procedure. Historical Review Since 1869, when Ashworth1 reported cells in the blood which appeared to be similar to the cells of the patient's multiple malignant skin tumors, several investigators2-4 have reported "abnormal cells" in the blood stream.In 1954 Cole, Packard, and Southwick,5 using the Papanicolaou slain, reported cancer cells in the fluid perfused through the major artery and collected from the vein of a References 1. Ashworth, T. R.: A Case of Cancer in Which Cells Similar to Those in the Tumours Were Seen in the Blood After Death , Australian M. J. 14:146, 1869. 2. Schleip, K.: Zur Diagnose von Knochenmarkstumoren aus dem Blutbefunde , Ztschr. klin. Med. 59:261, 1906. 3. Aschoff, L.: Ein Fall von Myelom , München. med. Wchnschr. 53:337, 1906. 4. Ward, G. R.: The Blood in Cancer with Bone Metastases , Lancet 1:676, 1913.Crossref 5. Cole, W. H.; Packard, D., and Southwick, H. W.: Carcinoma of the Colon with Special Reference to Prevention of Recurrence , J. A. M. A. 155:1549, 1954.Crossref 6. Fisher, E. R., and Turnbull, R. B., Jr.: The Cytologic Demonstration and Significance of Tumor Cells in the Mesenteric Venous Blood in Patients with Colorectal Carcinoma , Surg. Gynec, & Obst. 100:102, 1955. 7. Engell, H. C.: Cancer Cells in the Circulating Blood , Acta chir. scandinav. , (Supp. 201) , 1955. 8. Moore, G. E.; Sandberg, A., and Schubarg, J. R.: Clinical and Experimental Observations of the Occurrence and Fate of Tumor Cells in the Blood Stream , Ann. Surg. 146:580, 1957. 9. Roberts, S.; Watne, A.; McGrath, R.; McGrew, E., and Cole, W. H.: Technique and Results of Isolation of Cancer Cells from the Circulating Blood , A. M. A. Arch. Surg. 76:334, 1958. 10. Roberts, S. S.; Watne, A.; McGrath, R.; McGrew, E., and Cole, W. H.: The Response of Cancer Cells in the Circulating Blood to Surgical Stress and Chemotherapy, S. Forum, to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives Surgery American Medical Association

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References (9)

Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-6908
DOI
10.1001/archsurg.1959.04320050030004
Publisher site
See Article on Publisher Site

Abstract

Abstract Although it is generally believed that malignant tumors in children are associated with a poorer prognosis than are malignancies in adults, the reasons for such an assumption, other than clinical observation, have not been made clear. Vascular dissemination of cancer in children may be of importance in this regard. This study is concerned with that aspect of the vascular dissemination dealing with the carriage of cancer cells in the circulating blood of children, and the occurrence of these cells during an operative procedure. Historical Review Since 1869, when Ashworth1 reported cells in the blood which appeared to be similar to the cells of the patient's multiple malignant skin tumors, several investigators2-4 have reported "abnormal cells" in the blood stream.In 1954 Cole, Packard, and Southwick,5 using the Papanicolaou slain, reported cancer cells in the fluid perfused through the major artery and collected from the vein of a References 1. Ashworth, T. R.: A Case of Cancer in Which Cells Similar to Those in the Tumours Were Seen in the Blood After Death , Australian M. J. 14:146, 1869. 2. Schleip, K.: Zur Diagnose von Knochenmarkstumoren aus dem Blutbefunde , Ztschr. klin. Med. 59:261, 1906. 3. Aschoff, L.: Ein Fall von Myelom , München. med. Wchnschr. 53:337, 1906. 4. Ward, G. R.: The Blood in Cancer with Bone Metastases , Lancet 1:676, 1913.Crossref 5. Cole, W. H.; Packard, D., and Southwick, H. W.: Carcinoma of the Colon with Special Reference to Prevention of Recurrence , J. A. M. A. 155:1549, 1954.Crossref 6. Fisher, E. R., and Turnbull, R. B., Jr.: The Cytologic Demonstration and Significance of Tumor Cells in the Mesenteric Venous Blood in Patients with Colorectal Carcinoma , Surg. Gynec, & Obst. 100:102, 1955. 7. Engell, H. C.: Cancer Cells in the Circulating Blood , Acta chir. scandinav. , (Supp. 201) , 1955. 8. Moore, G. E.; Sandberg, A., and Schubarg, J. R.: Clinical and Experimental Observations of the Occurrence and Fate of Tumor Cells in the Blood Stream , Ann. Surg. 146:580, 1957. 9. Roberts, S.; Watne, A.; McGrath, R.; McGrew, E., and Cole, W. H.: Technique and Results of Isolation of Cancer Cells from the Circulating Blood , A. M. A. Arch. Surg. 76:334, 1958. 10. Roberts, S. S.; Watne, A.; McGrath, R.; McGrew, E., and Cole, W. H.: The Response of Cancer Cells in the Circulating Blood to Surgical Stress and Chemotherapy, S. Forum, to be published.

Journal

A.M.A. Archives SurgeryAmerican Medical Association

Published: May 1, 1959

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