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Effect of Antibacterial Agents on Clean Wounds

Effect of Antibacterial Agents on Clean Wounds Abstract Substances for local application to wounds continue to be offered and frequently recommended as adjuncts to epithelization, despite the known facts that chemicals applied to wounds generally retard their healing. Lister first recognized that his antiseptic agents often delayed rather than supported wound healing, and thus began the emphasis upon asepsis, rather than antisepsis. The sulfonamide drugs were widely used in wounds until clinical and experimental studies revealed them to be deleterious. Even with this, as each new antimicrobial agent is discovered, an ointment is invariably promoted for application to wound surfaces. These agents must be appraised, as they appear, in order that no harm should be done through their use. The study of the healing wound and inflammation has attracted many investigators, in an effort to understand better the physiologic processes involved. From these studies have come elaborate methods for following the wounds and discrening the processes. For the References 1. Brush, B. E., and Lam, C. R.: Effect of the Topical Application of Several Substances on the Healing of Experimental Cutaneous Wounds , Surgery 12:355, 1942. 2. Carrel, A., and Hartmann, A. J.: Cicatrization of Wounds: 1. Relation Between the Size of the Wound and the Rate of Its Cicatrization , J. Exper. Med. 24:429, 1916.Crossref 3. Harvey, S. C.: The Healing of the Wound as a Biologic Phenomenon , Surgery 25:655, 1949. 4. Ponka, J. L., and Lam, C. R.: Effect of Application of Several Antibacterial Substances on the Healing of Wounds , Arch. Surg. 59:57, 1949.Crossref 5. Tamerin, J. A.; Metzger, W. I., and Wright, L. T.: A New Aureomycin Dressing: Rationale and Use in Treatment of Surface Wounds , Am. J. Surg. 86:325, 1953.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives Surgery American Medical Association

Effect of Antibacterial Agents on Clean Wounds

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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-6908
DOI
10.1001/archsurg.1959.04320030124020
Publisher site
See Article on Publisher Site

Abstract

Abstract Substances for local application to wounds continue to be offered and frequently recommended as adjuncts to epithelization, despite the known facts that chemicals applied to wounds generally retard their healing. Lister first recognized that his antiseptic agents often delayed rather than supported wound healing, and thus began the emphasis upon asepsis, rather than antisepsis. The sulfonamide drugs were widely used in wounds until clinical and experimental studies revealed them to be deleterious. Even with this, as each new antimicrobial agent is discovered, an ointment is invariably promoted for application to wound surfaces. These agents must be appraised, as they appear, in order that no harm should be done through their use. The study of the healing wound and inflammation has attracted many investigators, in an effort to understand better the physiologic processes involved. From these studies have come elaborate methods for following the wounds and discrening the processes. For the References 1. Brush, B. E., and Lam, C. R.: Effect of the Topical Application of Several Substances on the Healing of Experimental Cutaneous Wounds , Surgery 12:355, 1942. 2. Carrel, A., and Hartmann, A. J.: Cicatrization of Wounds: 1. Relation Between the Size of the Wound and the Rate of Its Cicatrization , J. Exper. Med. 24:429, 1916.Crossref 3. Harvey, S. C.: The Healing of the Wound as a Biologic Phenomenon , Surgery 25:655, 1949. 4. Ponka, J. L., and Lam, C. R.: Effect of Application of Several Antibacterial Substances on the Healing of Wounds , Arch. Surg. 59:57, 1949.Crossref 5. Tamerin, J. A.; Metzger, W. I., and Wright, L. T.: A New Aureomycin Dressing: Rationale and Use in Treatment of Surface Wounds , Am. J. Surg. 86:325, 1953.Crossref

Journal

A.M.A. Archives SurgeryAmerican Medical Association

Published: Mar 1, 1959

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