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Experiences with the Extirpated Canine Lung as a Biologic Oxygenator

Experiences with the Extirpated Canine Lung as a Biologic Oxygenator Abstract One of the more interesting oxygenators which has resulted from investigative search in the realm of pump oxygenators is the extirpated dog lung. These lungs, being inexpensive and readily available, have been extensively tested in the laboratory and provide an effective means of oxygenating blood.2,4,5,7,10,11 In these experiments, the blood perfused through the "biologic" oxygenator has been homologous with it, and species difference was not considered. With homologous perfused lungs and, in some instances, perfused autogenous lobes, no deleterious effects on the organ were noticed, even after two hours of perfusion. The features of this extirpated organ adapting it to perform its exchange of oxygen and carbon dioxide have been summarized by Mustard, Chute, and Simmons, who state that it carries out good gaseous exchange without undue trauma to blood constituents, is an excellent filter for bacteria and small clots, and may perform certain detoxification functions.8 Early attempts References 1. Plavolex, provided by Wyeth Laboratories, Inc., Philadelphia. 2. Albritton, E. C., Editor: Standard Values in Blood , prepared under the direction of the Committee on Handbook of Biological Data, American Institute of Biological Sciences, National Research Council, Philadelphia, W. B. Saunders Company, 1953, p. 45. 3. Campbell, G. S.; Crisp, N. W., and Brown, E.: Maintenance of Respiratory Function with Isolated Lung Lobes During Inflow Occlusion , Proc. Soc. Exper. Biol. & Med. 88:390, 1955. 4. Campbell, G. S.; Crisp, N. W., and Brown, E. B.: Total Cardiac By-Pass in Humans Utilizing a Pump and Heterologous Lung Oxygenator (Dog Lungs) , Surgery 40:364, 1956. 5. Cohen, M., and Lillehei, L. W.: Autogenous Lung Oxygenator with Total Cardiac By-Pass for Intracardiac Surgery , S. Forum 4:34, 1953. 6. Cohen, M.; Warden, H. E., and Lillehei, C. W.: Physiologic and Metabolic Changes During Autogenous Lobe Oxygenation with Total Cardiac By-Pass Employing the Azygous Flow Principle , Surg. Gynec. & Obst. 98:523, 1954. 7. MacGregor, R. G.: Examination of the Pulmonary Circulation with the Microscope , J. Physiol. 80:65, 1933. 8. Mustard, W. T., and Chute, A. L.: Experimental Intracardiac Surgery with Extracorporeal Circulation , Surgery 30:684, 1951. 9. Mustard, W. T.; Chute, A. L., and Simmons, E. H.: Further Observations on Experimental Extracorporeal Circulation , Surgery 32:803, 1952. 10. Mustard, W. T.; Chute, A. L.; Keith, J. D.; Sirek, A.; Rowe, R. D., and Vlad, P.: A Surgical Approach to Transposition of the Great Vessels with Extracorporeal Circuit , Surgery 36:39, 1954. 11. Potts, W.; Riker, W. L.; DeBord, R., and Andrews, S. C.: Maintenance of Life by Homologous and Mechanical Circulation , Surgery 31:161, 1952. 12. Read, R. C.; George V. P.; Cohen, M., and Lillehei, C. W.: Cardiac By-Pass Using Autogenous Lung for Oxygenation , Surgery 40:840, 1956. 13. Wearn, J. T.; Einsterne, A. C.; Brown, A. W.; Ban, J. S.; German, W. J., and Zschiesche, L. J.: The Normal Behavior of the Pulmonary Blood Vessels with Observations in the Intermittence of the Flow of Blood in the Arterioles and Capillaries , Am. J. Physiol. 109:236, 1934. 14. Wesolowski, S. A.; Fisher, J. H., and Welch, C. S.: Heart-Lung By-Pass Using Pumps and Isolated Homologous Lungs , Surg. Gynec. & Obst. 95:762, 1952. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives Surgery American Medical Association

Experiences with the Extirpated Canine Lung as a Biologic Oxygenator

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References (14)

Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0096-6908
DOI
10.1001/archsurg.1957.01280130065012
Publisher site
See Article on Publisher Site

Abstract

Abstract One of the more interesting oxygenators which has resulted from investigative search in the realm of pump oxygenators is the extirpated dog lung. These lungs, being inexpensive and readily available, have been extensively tested in the laboratory and provide an effective means of oxygenating blood.2,4,5,7,10,11 In these experiments, the blood perfused through the "biologic" oxygenator has been homologous with it, and species difference was not considered. With homologous perfused lungs and, in some instances, perfused autogenous lobes, no deleterious effects on the organ were noticed, even after two hours of perfusion. The features of this extirpated organ adapting it to perform its exchange of oxygen and carbon dioxide have been summarized by Mustard, Chute, and Simmons, who state that it carries out good gaseous exchange without undue trauma to blood constituents, is an excellent filter for bacteria and small clots, and may perform certain detoxification functions.8 Early attempts References 1. Plavolex, provided by Wyeth Laboratories, Inc., Philadelphia. 2. Albritton, E. C., Editor: Standard Values in Blood , prepared under the direction of the Committee on Handbook of Biological Data, American Institute of Biological Sciences, National Research Council, Philadelphia, W. B. Saunders Company, 1953, p. 45. 3. Campbell, G. S.; Crisp, N. W., and Brown, E.: Maintenance of Respiratory Function with Isolated Lung Lobes During Inflow Occlusion , Proc. Soc. Exper. Biol. & Med. 88:390, 1955. 4. Campbell, G. S.; Crisp, N. W., and Brown, E. B.: Total Cardiac By-Pass in Humans Utilizing a Pump and Heterologous Lung Oxygenator (Dog Lungs) , Surgery 40:364, 1956. 5. Cohen, M., and Lillehei, L. W.: Autogenous Lung Oxygenator with Total Cardiac By-Pass for Intracardiac Surgery , S. Forum 4:34, 1953. 6. Cohen, M.; Warden, H. E., and Lillehei, C. W.: Physiologic and Metabolic Changes During Autogenous Lobe Oxygenation with Total Cardiac By-Pass Employing the Azygous Flow Principle , Surg. Gynec. & Obst. 98:523, 1954. 7. MacGregor, R. G.: Examination of the Pulmonary Circulation with the Microscope , J. Physiol. 80:65, 1933. 8. Mustard, W. T., and Chute, A. L.: Experimental Intracardiac Surgery with Extracorporeal Circulation , Surgery 30:684, 1951. 9. Mustard, W. T.; Chute, A. L., and Simmons, E. H.: Further Observations on Experimental Extracorporeal Circulation , Surgery 32:803, 1952. 10. Mustard, W. T.; Chute, A. L.; Keith, J. D.; Sirek, A.; Rowe, R. D., and Vlad, P.: A Surgical Approach to Transposition of the Great Vessels with Extracorporeal Circuit , Surgery 36:39, 1954. 11. Potts, W.; Riker, W. L.; DeBord, R., and Andrews, S. C.: Maintenance of Life by Homologous and Mechanical Circulation , Surgery 31:161, 1952. 12. Read, R. C.; George V. P.; Cohen, M., and Lillehei, C. W.: Cardiac By-Pass Using Autogenous Lung for Oxygenation , Surgery 40:840, 1956. 13. Wearn, J. T.; Einsterne, A. C.; Brown, A. W.; Ban, J. S.; German, W. J., and Zschiesche, L. J.: The Normal Behavior of the Pulmonary Blood Vessels with Observations in the Intermittence of the Flow of Blood in the Arterioles and Capillaries , Am. J. Physiol. 109:236, 1934. 14. Wesolowski, S. A.; Fisher, J. H., and Welch, C. S.: Heart-Lung By-Pass Using Pumps and Isolated Homologous Lungs , Surg. Gynec. & Obst. 95:762, 1952.

Journal

A.M.A. Archives SurgeryAmerican Medical Association

Published: Jul 1, 1957

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