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The Homograft Rejection Mechanism

The Homograft Rejection Mechanism Abstract Introduction The general purpose of this study was to learn more about the homograft rejection mechanism. We realized that previous studies were not clear as to the morphology and dynamics of grafting. Only by animal study can the variables be sufficiently controlled to draw reliable conclusions.We selected a small mammal because of known similarities to the human, in giving birth to living young and in the existence of species individuality.The mouse seemed ideal, since the development of inbred strains has given us individuals that are so nearly identical, genetically, that tissues may be transferred between individual isogenic mice with the same success encountered when autografting in the human. Recently, Eichwald8 has shown that certain isogenetic grafts from males onto females will not "take" as consistently as autografts, but in general these strains are comparable in genetic similarity to human identical twins. Thus the isograft in the mouse References 1. Sandison, J. G.: A New Method for the Microscopic Study of Living Tissues by the Introduction of a Transparent Chamber in the Rabbit's Ear , Anat. Rec. 28:281, 1924.Crossref 2. Clark, E. R., and others: Recent Modifications in the Method of Studying Living Cells and Tissues in Transparent Chambers in the Rabbit's Ear , Anat. Rec. 47:187, 1930.Crossref 3. Algire, G. H., and Legallais, F. V.: Recent Developments in the Transparent-Chamber Technique as Adapted to the Mouse , J. Nat. Cancer Inst. 10:225, 1949. 4. Joslin, D.: A Tissue Chamber and Splint for the Mouse , Science 115:601, 1952.Crossref 5. Edgerton, M. T., and Edgerton, P. J.: A Simplified Transparent Chamber Technique for Studies of Grafting in the Mouse, to be published. 6. Billingham, R. E., and Medawar, P. B.: The Technique of Free Skin Grafting in Mammals , J. Exper. Biol. 28:385, 1951. 7. Edgerton, M. T., and Edgerton, P. J.: Skin-Vascularization of Homografts , Transplantation Bull. 2:98, 1955. 8. Eichwald, E. J., and Silmser, C. R.: The Genetics of Skin Grafting, Presented at the Second Tissue Homotransplantation Conference, New York Academy of Sciences, February, 1956. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives Surgery American Medical Association

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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0096-6908
DOI
10.1001/archsurg.1957.01280080090014
Publisher site
See Article on Publisher Site

Abstract

Abstract Introduction The general purpose of this study was to learn more about the homograft rejection mechanism. We realized that previous studies were not clear as to the morphology and dynamics of grafting. Only by animal study can the variables be sufficiently controlled to draw reliable conclusions.We selected a small mammal because of known similarities to the human, in giving birth to living young and in the existence of species individuality.The mouse seemed ideal, since the development of inbred strains has given us individuals that are so nearly identical, genetically, that tissues may be transferred between individual isogenic mice with the same success encountered when autografting in the human. Recently, Eichwald8 has shown that certain isogenetic grafts from males onto females will not "take" as consistently as autografts, but in general these strains are comparable in genetic similarity to human identical twins. Thus the isograft in the mouse References 1. Sandison, J. G.: A New Method for the Microscopic Study of Living Tissues by the Introduction of a Transparent Chamber in the Rabbit's Ear , Anat. Rec. 28:281, 1924.Crossref 2. Clark, E. R., and others: Recent Modifications in the Method of Studying Living Cells and Tissues in Transparent Chambers in the Rabbit's Ear , Anat. Rec. 47:187, 1930.Crossref 3. Algire, G. H., and Legallais, F. V.: Recent Developments in the Transparent-Chamber Technique as Adapted to the Mouse , J. Nat. Cancer Inst. 10:225, 1949. 4. Joslin, D.: A Tissue Chamber and Splint for the Mouse , Science 115:601, 1952.Crossref 5. Edgerton, M. T., and Edgerton, P. J.: A Simplified Transparent Chamber Technique for Studies of Grafting in the Mouse, to be published. 6. Billingham, R. E., and Medawar, P. B.: The Technique of Free Skin Grafting in Mammals , J. Exper. Biol. 28:385, 1951. 7. Edgerton, M. T., and Edgerton, P. J.: Skin-Vascularization of Homografts , Transplantation Bull. 2:98, 1955. 8. Eichwald, E. J., and Silmser, C. R.: The Genetics of Skin Grafting, Presented at the Second Tissue Homotransplantation Conference, New York Academy of Sciences, February, 1956.

Journal

A.M.A. Archives SurgeryAmerican Medical Association

Published: Feb 1, 1957

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