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CORTICOTROPIN (ACTH) IN TREATMENT OF KELOIDS

CORTICOTROPIN (ACTH) IN TREATMENT OF KELOIDS Abstract THE WELL-DOCUMENTED reports of the effect of corticotropin (ACTH) in reducing fibroplasia stimulated our study of this agent in the treatment of keloids.1 Two methods were used: First, the keloids were excised and the patient was treated with corticotropin in the postoperative period. Second, corticotropin was combined with hyaluronidase and injected directly into the keloid. 1. SURGERY AND POSTOPERATIVE ADMINISTRATION OF CORTICOTROPIN The first patient was a child 2 years old who had a large confluent keloid which fused the first, second, and third toes of the right foot into one mass of reddened, elevated scar. This keloid, which developed after surgical treatment for syndactylism at another hospital, completely obliterated the interdigital spaces. That this lesion was a true keloid rather than a hypertrophic scar was evidenced by its growth into cutaneous areas beyond the site of original surgical trauma. Keloidal tissue was excised in toto; the raw References 1. Spain, D. M.; Molomut, N., and Haber, A.: Biological Studies on Cortisone in Mice , Science 112:335, 1950.Crossref 2. Ragan, C.; Howes, E. L.; Plotz, C. M.: Meyer, K.; Blunt, J. W., and Lattes, R.: The Effect of ACTH and Cortisone on Connective Tissue , Bull. New York Acad. Med. 26:251, 1950. 3. Conference on Connective Tissues: Transactions of First of Conference, New York, April 24-25, 1950 , edited by C. Ragan, New York, Josiah Macy, Jr., Foundation, 1951. 4. Howes, E. L.; Plotz, C. M.; Blunt, J. W., and Ragan, C.: Retardation of Wound Healing by Cortisone , Surgery 28:177, 1950. 5. Cornman, I.: Selective Damage to Fibroblasts by Desoxycorticosterone in Cultures of Mixed Tissues , Science 113:37, 1951.Crossref 6. Baker, B. L., and Costor, C. W.: Cutaneous Atrophy Induced by Local Treatment with Adrenocortical Steroids , Anat. Rec. 106:173, 1950.Crossref 7. Creditor, M. C.; Bevans, M.; Mundy, W. L., and Ragan, C.: Effect of ACTH on Wound Healing in Humans , Proc. Soc. Exper. Biol. & Med. 74:245, 1950. 8. Baxter, H.; Schiller, C.; Whiteside, J., and Straith, R. E.: The Influence of Cortisone on Skin and Wound Healing in Experimental Animals , Plast. & Reconstruct. Surg. 7:24, 1951. 9. Plotz, C. M.; Howes, E. L.; Meyer, K.; Blunt, J. W.; Lattes, R., and Ragan, C.: The Effect of the Hyperadrenal State on Connective Tissue , Am. J. Path. 26:709, 1950. 10. Stinchfield, F. E.: Experimental and Clinical Use of Oxidized Cellulose and Cortisone in the Prevention of Excess Bone and Fibrous-Tissue Formation , J. Bone & Joint Surg. 32-A:739, 1950. 11. Wydase, lyophilized hyaluronidase, supplied by Wyeth, Inc., Philadelphia. 12. Hudack, S. S.; Blunt, J. W.; Higbee, P., and Kearin, G. M.: A Probable Acid Mucopolysaccharide Present in Granulation Tissue , Proc. Soc. Exper. Biol. & Med. 72:526, 1949. 13. Meyer, K.: Biological Significance of Hyaluronic Acid and Hyaluronidase , Physiol. Rev. 27:335, 1947. 14. Seifter, J.; Baeder, D. H., and Dervines, A.: Alteration in Permeability of Some Membranes by Hyaluronidase and Inhibition of this Effect by Steroids , Proc. Soc. Exper. Biol. & Med. 72:136, 1949. 15. Weinstein, L.: Further Studies on the Prophylaxis of Experimental Infections and Intoxications with Various Hormone Preparations , Yale J. Biol. & Med. 12:549, 1940. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives Surgery American Medical Association

CORTICOTROPIN (ACTH) IN TREATMENT OF KELOIDS

A.M.A. Archives Surgery , Volume 64 (1) – Jan 1, 1952

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References (14)

Publisher
American Medical Association
Copyright
Copyright © 1952 American Medical Association. All Rights Reserved.
ISSN
0096-6908
DOI
10.1001/archsurg.1952.01260010058006
Publisher site
See Article on Publisher Site

Abstract

Abstract THE WELL-DOCUMENTED reports of the effect of corticotropin (ACTH) in reducing fibroplasia stimulated our study of this agent in the treatment of keloids.1 Two methods were used: First, the keloids were excised and the patient was treated with corticotropin in the postoperative period. Second, corticotropin was combined with hyaluronidase and injected directly into the keloid. 1. SURGERY AND POSTOPERATIVE ADMINISTRATION OF CORTICOTROPIN The first patient was a child 2 years old who had a large confluent keloid which fused the first, second, and third toes of the right foot into one mass of reddened, elevated scar. This keloid, which developed after surgical treatment for syndactylism at another hospital, completely obliterated the interdigital spaces. That this lesion was a true keloid rather than a hypertrophic scar was evidenced by its growth into cutaneous areas beyond the site of original surgical trauma. Keloidal tissue was excised in toto; the raw References 1. Spain, D. M.; Molomut, N., and Haber, A.: Biological Studies on Cortisone in Mice , Science 112:335, 1950.Crossref 2. Ragan, C.; Howes, E. L.; Plotz, C. M.: Meyer, K.; Blunt, J. W., and Lattes, R.: The Effect of ACTH and Cortisone on Connective Tissue , Bull. New York Acad. Med. 26:251, 1950. 3. Conference on Connective Tissues: Transactions of First of Conference, New York, April 24-25, 1950 , edited by C. Ragan, New York, Josiah Macy, Jr., Foundation, 1951. 4. Howes, E. L.; Plotz, C. M.; Blunt, J. W., and Ragan, C.: Retardation of Wound Healing by Cortisone , Surgery 28:177, 1950. 5. Cornman, I.: Selective Damage to Fibroblasts by Desoxycorticosterone in Cultures of Mixed Tissues , Science 113:37, 1951.Crossref 6. Baker, B. L., and Costor, C. W.: Cutaneous Atrophy Induced by Local Treatment with Adrenocortical Steroids , Anat. Rec. 106:173, 1950.Crossref 7. Creditor, M. C.; Bevans, M.; Mundy, W. L., and Ragan, C.: Effect of ACTH on Wound Healing in Humans , Proc. Soc. Exper. Biol. & Med. 74:245, 1950. 8. Baxter, H.; Schiller, C.; Whiteside, J., and Straith, R. E.: The Influence of Cortisone on Skin and Wound Healing in Experimental Animals , Plast. & Reconstruct. Surg. 7:24, 1951. 9. Plotz, C. M.; Howes, E. L.; Meyer, K.; Blunt, J. W.; Lattes, R., and Ragan, C.: The Effect of the Hyperadrenal State on Connective Tissue , Am. J. Path. 26:709, 1950. 10. Stinchfield, F. E.: Experimental and Clinical Use of Oxidized Cellulose and Cortisone in the Prevention of Excess Bone and Fibrous-Tissue Formation , J. Bone & Joint Surg. 32-A:739, 1950. 11. Wydase, lyophilized hyaluronidase, supplied by Wyeth, Inc., Philadelphia. 12. Hudack, S. S.; Blunt, J. W.; Higbee, P., and Kearin, G. M.: A Probable Acid Mucopolysaccharide Present in Granulation Tissue , Proc. Soc. Exper. Biol. & Med. 72:526, 1949. 13. Meyer, K.: Biological Significance of Hyaluronic Acid and Hyaluronidase , Physiol. Rev. 27:335, 1947. 14. Seifter, J.; Baeder, D. H., and Dervines, A.: Alteration in Permeability of Some Membranes by Hyaluronidase and Inhibition of this Effect by Steroids , Proc. Soc. Exper. Biol. & Med. 72:136, 1949. 15. Weinstein, L.: Further Studies on the Prophylaxis of Experimental Infections and Intoxications with Various Hormone Preparations , Yale J. Biol. & Med. 12:549, 1940.

Journal

A.M.A. Archives SurgeryAmerican Medical Association

Published: Jan 1, 1952

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