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USE OF HUMAN FIBRIN FOAM AND THROMBIN SOLUTION AS HEMOSTATIC AGENTS IN GENERAL SURGERY

USE OF HUMAN FIBRIN FOAM AND THROMBIN SOLUTION AS HEMOSTATIC AGENTS IN GENERAL SURGERY Abstract HEMOSTASIS always presents a major problem to the surgeon. Where bleeding is brisk, as from a severed artery or large vein, it is usually stopped immediately by the application of forceps and ligatures. Much more difficult to control is the constant oozing that results from injury to small venules and capillaries. If one measures loss of blood by the increment of gain in dry sponges,1 it becomes readily apparent that most of the loss of blood during the usual major surgical procedure is from the latter, rather than from the former, source of bleeding. Bleeding from brain, kidney, liver or vascular tumors is difficult to control by the application of forceps or clips because of the friability of the tissues. In an operative field where infection is present or has subsided (as in decortication of a lung), the bleeding from the friable and tough fibrous tissue is most difficult References 1. Wangensteen, O. H.: The Controlled Administration of Fluid to Surgical Patients , Minnesota Med. 25:783-801, 1942. 2. Cushing, H.: Control of Bleeding in Operations for Brain Tumor , Ann Surg. 54:1-19, 1911.Crossref 3. Grey, E. G.: Fibrin as an Haemostatic in Cerebral Surgery , Surg., Gynec. & Obst. 21:452-454, 1915. 4. Seegers, W. H.; Smith, H. P.; Warner, E. D., and Brinkhous, K. M.: The Purification of Prothrombin , J. Biol. Chem. 123:751-754, 1938. 5. Correll, J. T.; Prentice, H. R., and Wise, E. C.: Biological Investigation of a New Absorbable Sponge , Surg., Gynec. & Obst. 81:585-589, 1945. 6. Light, R. V., and Prentice, H. R.: Gelatin Sponge: Surgical Investigation of a New Matrix Used in Conjunction with Thrombin in Hemostasis , Arch. Surg. 51:69-77 ( (Sept.) ) 1945. 7. Yockel, E. C., and Kenyon, W. O.: The Oxidation of Cellulose by Nitrogen Dioxide , J. Am. Chem. Soc. 64:121-126, 1942. 8. Unruh, C. C., and Kenyon, W. O.: Investigation of the Properties of Cellulose Oxidized by Nitrogen Dioxide , J. Am. Chem. Soc. 64:127-131, 1942. 9. Putnam, T. J.: The Use of Thrombin in Soluble Cellulose in Neurosurgery: Clinical Application , Ann. Surg. 118:127-129, 1943. 10. Seegers, W. H., and Doub, L.: Oxidized Cellulose and Thrombin , Proc. Soc. Exper. Biol. & Med. 56:72-73, 1944. 11. Uihlein, A.; Claggett, O. T., and Osterberg, A. E.: The Use of Oxidized Cellulose for Hemostasis in Surgical Procedures: Preliminary Report , Proc. Staff Meet., Mayo Clin. 20:29-32, 1945. 12. Frantz, V. K.: Absorbable Cotton, Paper and Gauze (Oxidized Cellulose) , Ann. Surg. 118:116-126, 1943. 13. Frantz, V. K.; Clarke, H. T., and Lattes, R.: Hemostasis with Absorbable Gauze , Ann. Surg. 120:181-199, 1944. 14. Frantz, V. K.: New Methods of Hemostasis , S. Clin. North America 25:338-347, 1945. 15. Cohn, E. J.; Oncley, J. L.; Strong, L. E.; Hughes, W. L., and Armstrong, S. H., Jr.: Chemical, Clinical and Immunological Studies on the Products of Human Plasma Fractionation: I. The Characterization of the Protein Fractions of Human Plasma , J. Clin. Investigation 23:412-432, 1944. 16. Edsall, J. T.; Ferry, R. M., and Armstrong, S. H., Jr.: Chemical, Clinical and Immunological Studies on the Products of Human Plasma Fractionation: XV. The Proteins Concerned in the Blood Coagulation Mechanism , J. Clin. Investigation 23:557-565, 1944. 17. Ingraham, F. D., and Bailey, O. T.: The Use of Products Prepared from Human Thrombin in Neurosurgery: Fibrin Foam as Hemostatic Agents, Fibrin Films in Repair of Dural Defects and in Prevention of Meningocerebral Adhesions , J. Neurosurg. 1:23-29, 1944. 18. Bailey, O. T.; Ingraham, F. D.; Swenson, O.; Lowrey, J. T., and Bering, E. A., Jr.: Human Fibrin Foam with Thrombin as Hemostatic Agent in General Surgery , Surgery 18:347-367, 1915. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

USE OF HUMAN FIBRIN FOAM AND THROMBIN SOLUTION AS HEMOSTATIC AGENTS IN GENERAL SURGERY

STATE, DAVID
Archives of Surgery , Volume 58 (3) – Mar 1, 1949
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References (25)

Publisher
American Medical Association
Copyright
Copyright © 1949 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1949.01240030290005
Publisher site
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Abstract

Abstract HEMOSTASIS always presents a major problem to the surgeon. Where bleeding is brisk, as from a severed artery or large vein, it is usually stopped immediately by the application of forceps and ligatures. Much more difficult to control is the constant oozing that results from injury to small venules and capillaries. If one measures loss of blood by the increment of gain in dry sponges,1 it becomes readily apparent that most of the loss of blood during the usual major surgical procedure is from the latter, rather than from the former, source of bleeding. Bleeding from brain, kidney, liver or vascular tumors is difficult to control by the application of forceps or clips because of the friability of the tissues. In an operative field where infection is present or has subsided (as in decortication of a lung), the bleeding from the friable and tough fibrous tissue is most difficult References 1. Wangensteen, O. H.: The Controlled Administration of Fluid to Surgical Patients , Minnesota Med. 25:783-801, 1942. 2. Cushing, H.: Control of Bleeding in Operations for Brain Tumor , Ann Surg. 54:1-19, 1911.Crossref 3. Grey, E. G.: Fibrin as an Haemostatic in Cerebral Surgery , Surg., Gynec. & Obst. 21:452-454, 1915. 4. Seegers, W. H.; Smith, H. P.; Warner, E. D., and Brinkhous, K. M.: The Purification of Prothrombin , J. Biol. Chem. 123:751-754, 1938. 5. Correll, J. T.; Prentice, H. R., and Wise, E. C.: Biological Investigation of a New Absorbable Sponge , Surg., Gynec. & Obst. 81:585-589, 1945. 6. Light, R. V., and Prentice, H. R.: Gelatin Sponge: Surgical Investigation of a New Matrix Used in Conjunction with Thrombin in Hemostasis , Arch. Surg. 51:69-77 ( (Sept.) ) 1945. 7. Yockel, E. C., and Kenyon, W. O.: The Oxidation of Cellulose by Nitrogen Dioxide , J. Am. Chem. Soc. 64:121-126, 1942. 8. Unruh, C. C., and Kenyon, W. O.: Investigation of the Properties of Cellulose Oxidized by Nitrogen Dioxide , J. Am. Chem. Soc. 64:127-131, 1942. 9. Putnam, T. J.: The Use of Thrombin in Soluble Cellulose in Neurosurgery: Clinical Application , Ann. Surg. 118:127-129, 1943. 10. Seegers, W. H., and Doub, L.: Oxidized Cellulose and Thrombin , Proc. Soc. Exper. Biol. & Med. 56:72-73, 1944. 11. Uihlein, A.; Claggett, O. T., and Osterberg, A. E.: The Use of Oxidized Cellulose for Hemostasis in Surgical Procedures: Preliminary Report , Proc. Staff Meet., Mayo Clin. 20:29-32, 1945. 12. Frantz, V. K.: Absorbable Cotton, Paper and Gauze (Oxidized Cellulose) , Ann. Surg. 118:116-126, 1943. 13. Frantz, V. K.; Clarke, H. T., and Lattes, R.: Hemostasis with Absorbable Gauze , Ann. Surg. 120:181-199, 1944. 14. Frantz, V. K.: New Methods of Hemostasis , S. Clin. North America 25:338-347, 1945. 15. Cohn, E. J.; Oncley, J. L.; Strong, L. E.; Hughes, W. L., and Armstrong, S. H., Jr.: Chemical, Clinical and Immunological Studies on the Products of Human Plasma Fractionation: I. The Characterization of the Protein Fractions of Human Plasma , J. Clin. Investigation 23:412-432, 1944. 16. Edsall, J. T.; Ferry, R. M., and Armstrong, S. H., Jr.: Chemical, Clinical and Immunological Studies on the Products of Human Plasma Fractionation: XV. The Proteins Concerned in the Blood Coagulation Mechanism , J. Clin. Investigation 23:557-565, 1944. 17. Ingraham, F. D., and Bailey, O. T.: The Use of Products Prepared from Human Thrombin in Neurosurgery: Fibrin Foam as Hemostatic Agents, Fibrin Films in Repair of Dural Defects and in Prevention of Meningocerebral Adhesions , J. Neurosurg. 1:23-29, 1944. 18. Bailey, O. T.; Ingraham, F. D.; Swenson, O.; Lowrey, J. T., and Bering, E. A., Jr.: Human Fibrin Foam with Thrombin as Hemostatic Agent in General Surgery , Surgery 18:347-367, 1915.

Journal

Archives of Surgery – American Medical Association

Published: Mar 1, 1949

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