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POTASSIUM METABOLISM IN THE IMMEDIATE POSTOPERATIVE PERIOD

POTASSIUM METABOLISM IN THE IMMEDIATE POSTOPERATIVE PERIOD Abstract MANY studies on the behavior of body fluids have led to an increasing interest in the subject of cellular electrolytes and the transfer of cations across the cell barrier. Losses of the main cellular cation, potassium, in "excess" of nitrogen have been reported in fasting,1 dehydration,2 diabetic coma3 and diarrhea.4 Furthermore, partial replacement of deficits of cell potassium by extracellular sodium have been effected in animals5 on low potassium-high sodium diets, in animals treated with desoxycorticosterone6 and in patients with alkalosis7 and infants with diarrhea.8 The administration of potassium as well as sodium has beenfound to have therapeutic value in some of these conditions. In this paper data of potassium and nitrogen losses have been analyzed from a large number of infusion studies in control subjects and patients undergoing mild and traumatizing operations (herniorrhaphies and combined abdominoperineal resections for carcinoma of the References 1. Benedict, F. G.: A Study of Prolonged Fasting , Publication 203, Carnegie Institute of Washington, 1915. 2. Elkinton, J. R., and Winkler, A. W.: Transfers of Intracellular Potassium in Experimental Dehydration , J. Clin. Investigation 23:93-101 ( (Jan.) ) 1944.Crossref 3. Atchley, D. W.; Loeb, R. F.; Richards, D. W., Jr.; Benedict, E. M., and Driscol, M. E.: On Diabetic Acidosis: A Detailed Study of Electrolyte Balances Following the Withdrawal and Reestablishment of Insulin Therapy , J. Clin. Investigation 12:297-326 ( (March) ) 1933.Crossref 4. Butler, A. M.; McKhann, C. F., and Gamble, J. L.: Intracellular Fluid Loss in Diarrheal Disease , J. Pediat. 3:84-92 ( (July) ) 1933.Crossref 5. Miller, H. C., and Darrow, D. C.: Relation of Muscle Electrolyte to Alterations in Serum Potassium and to the Toxic Effects of Injected Potassium Chloride , Am. J. Physiol. 130:747-758 ( (Oct.) ) 1940. 6. Ferrebee, J. N.; Parker, D.; Carnes, W. H.; Gerity, M. K.; Atchley, D. W., and Loeb, R. F.: Certain Effects of Desoxycorticosterone: The Development of "Diabetes Insipidus" and the Replacement of Muscle Potassium by Sodium in Normal Dog , Am. J. Physiol. 135:230-237 ( (Dec.) ) 1941. 7. Gamble, J. L.; Fahey, K. R.; Appleton, J. E., and MacLachlan, E. A.: Congenital Alkalosis with Diarrhea , J. Pediat. 26:509-518 ( (June) ) 1945.Crossref 8. Darrow, D. C.: Congenital Alkalosis with Diarrhea , J. Pediat. 26:519-532 ( (June) ) 1945.Crossref 9. Darrow, D. C.: The Retention of Electrolyte During Recovery from Severe Dehydration Due to Diarrhea , J. Pediat. 28:515-540 ( (May) ) 1946.Crossref 10. Coller, F. A.; lob, V.; Kalder, N. B.; Vaugan, H. H., and Moyer, C. A.: Translocation of Fluid Produced by Intravenous Administration of Isotonic Salt Solutions in Man Postoperatively , Ann. Surg. 122:663-677 ( (Oct.) ) 1945.Crossref 11. lob, V., and Swanson, W. W.: Mineral Growth in the Fetus , Am. J. Dis. Child. 47:302-306 [ (Feb.) ] 1934 12. Gamble, J. L.; Ross, G. S., and Tisdall, F. F.: The Metabolism of Fixed Base During Fasting , J. Biol. Chem. 57:633-695 ( (Oct.) ) 1923. 13. Byrom, F. B.: The Effect of a Diet of Pure Glucose on the Fluid Balance of the Body , Clin. Sc. 1:245-250 ( (Nov.) ) 1934. 14. Stewart, J. D., and Rourke, G. M.: The Effects of Large Intravenous Infusions on Body Fluid , J. Clin. Investigation 21:197-205 ( (March) ) 1942.Crossref 15. Thaler, J. I.: Evidence of Permeability of Tissue to Potassium , Proc. Soc. Exper. Biol. & Med. 33:368-371 ( (Dec.) ) 1935. 16. Darrow, D. C., and Yannet, H.: Changes in Distribution of Body Water Accompanying Increase and Decrease in Extracellular Electrolyte , J. Clin. Investigation 14:266-275 ( (March) ) 1935. 17. Reifenstein, E. C., Jr.: Read before the Conference on Metabolic Aspects of Convalesence, Oct. 15, 1945. 18. Moyer, C. A.: Fluid and Electrolyte Balance , Surg., Gynec. & Obst. 84: 586-599 ( (April) ) 1947. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

POTASSIUM METABOLISM IN THE IMMEDIATE POSTOPERATIVE PERIOD

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References (17)

Publisher
American Medical Association
Copyright
Copyright © 1948 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1948.01240020477004
Publisher site
See Article on Publisher Site

Abstract

Abstract MANY studies on the behavior of body fluids have led to an increasing interest in the subject of cellular electrolytes and the transfer of cations across the cell barrier. Losses of the main cellular cation, potassium, in "excess" of nitrogen have been reported in fasting,1 dehydration,2 diabetic coma3 and diarrhea.4 Furthermore, partial replacement of deficits of cell potassium by extracellular sodium have been effected in animals5 on low potassium-high sodium diets, in animals treated with desoxycorticosterone6 and in patients with alkalosis7 and infants with diarrhea.8 The administration of potassium as well as sodium has beenfound to have therapeutic value in some of these conditions. In this paper data of potassium and nitrogen losses have been analyzed from a large number of infusion studies in control subjects and patients undergoing mild and traumatizing operations (herniorrhaphies and combined abdominoperineal resections for carcinoma of the References 1. Benedict, F. G.: A Study of Prolonged Fasting , Publication 203, Carnegie Institute of Washington, 1915. 2. Elkinton, J. R., and Winkler, A. W.: Transfers of Intracellular Potassium in Experimental Dehydration , J. Clin. Investigation 23:93-101 ( (Jan.) ) 1944.Crossref 3. Atchley, D. W.; Loeb, R. F.; Richards, D. W., Jr.; Benedict, E. M., and Driscol, M. E.: On Diabetic Acidosis: A Detailed Study of Electrolyte Balances Following the Withdrawal and Reestablishment of Insulin Therapy , J. Clin. Investigation 12:297-326 ( (March) ) 1933.Crossref 4. Butler, A. M.; McKhann, C. F., and Gamble, J. L.: Intracellular Fluid Loss in Diarrheal Disease , J. Pediat. 3:84-92 ( (July) ) 1933.Crossref 5. Miller, H. C., and Darrow, D. C.: Relation of Muscle Electrolyte to Alterations in Serum Potassium and to the Toxic Effects of Injected Potassium Chloride , Am. J. Physiol. 130:747-758 ( (Oct.) ) 1940. 6. Ferrebee, J. N.; Parker, D.; Carnes, W. H.; Gerity, M. K.; Atchley, D. W., and Loeb, R. F.: Certain Effects of Desoxycorticosterone: The Development of "Diabetes Insipidus" and the Replacement of Muscle Potassium by Sodium in Normal Dog , Am. J. Physiol. 135:230-237 ( (Dec.) ) 1941. 7. Gamble, J. L.; Fahey, K. R.; Appleton, J. E., and MacLachlan, E. A.: Congenital Alkalosis with Diarrhea , J. Pediat. 26:509-518 ( (June) ) 1945.Crossref 8. Darrow, D. C.: Congenital Alkalosis with Diarrhea , J. Pediat. 26:519-532 ( (June) ) 1945.Crossref 9. Darrow, D. C.: The Retention of Electrolyte During Recovery from Severe Dehydration Due to Diarrhea , J. Pediat. 28:515-540 ( (May) ) 1946.Crossref 10. Coller, F. A.; lob, V.; Kalder, N. B.; Vaugan, H. H., and Moyer, C. A.: Translocation of Fluid Produced by Intravenous Administration of Isotonic Salt Solutions in Man Postoperatively , Ann. Surg. 122:663-677 ( (Oct.) ) 1945.Crossref 11. lob, V., and Swanson, W. W.: Mineral Growth in the Fetus , Am. J. Dis. Child. 47:302-306 [ (Feb.) ] 1934 12. Gamble, J. L.; Ross, G. S., and Tisdall, F. F.: The Metabolism of Fixed Base During Fasting , J. Biol. Chem. 57:633-695 ( (Oct.) ) 1923. 13. Byrom, F. B.: The Effect of a Diet of Pure Glucose on the Fluid Balance of the Body , Clin. Sc. 1:245-250 ( (Nov.) ) 1934. 14. Stewart, J. D., and Rourke, G. M.: The Effects of Large Intravenous Infusions on Body Fluid , J. Clin. Investigation 21:197-205 ( (March) ) 1942.Crossref 15. Thaler, J. I.: Evidence of Permeability of Tissue to Potassium , Proc. Soc. Exper. Biol. & Med. 33:368-371 ( (Dec.) ) 1935. 16. Darrow, D. C., and Yannet, H.: Changes in Distribution of Body Water Accompanying Increase and Decrease in Extracellular Electrolyte , J. Clin. Investigation 14:266-275 ( (March) ) 1935. 17. Reifenstein, E. C., Jr.: Read before the Conference on Metabolic Aspects of Convalesence, Oct. 15, 1945. 18. Moyer, C. A.: Fluid and Electrolyte Balance , Surg., Gynec. & Obst. 84: 586-599 ( (April) ) 1947.

Journal

Archives of SurgeryAmerican Medical Association

Published: Oct 1, 1948

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