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NOCTURNAL GASTRIC SECRETION: Studies on Normal Subjects and on Patients with Duodenal Ulcer, Gastric Ulcer and Gastric Carcinoma

NOCTURNAL GASTRIC SECRETION: Studies on Normal Subjects and on Patients with Duodenal Ulcer,... Abstract THE PURPOSE of this paper is to present the results of studies on the gastric secretion of normal persons and of patients with duodenal ulcer, gastric ulcer and gastric carcinoma. Henning and Norpoth,1 Winkelstein2 and Val Dez3 observed a greater free acidity in the nocturnal secretion of patients with duodenal ulcer than in that of a normal group. Sandweiss and others,4 on the other hand, concluded that male patients with uncomplicated duodenal ulcer do not secrete larger amounts of gastric juice than normal persons during the period from midnight to 7 a.m. It is difficult to compare the results obtained by these various workers inasmuch as varying methods of study were employed. Dragstedt and his co-workers5 found that the average volume of the twelve hour continuous gastric secretion in 135 unselected patients with duodenal ulcer was 1,085 cc.; the average free acidity of the total References 1. Henning, N., and Norpoth, L.: Untersuchungen über die sekretorische Funktion des Magens während des nächtlichen Schlafes , Arch. f. Verdauungskr. 53:64, 1933.Crossref 2. Winkelstein, A.: One Hundred and Sixty-Nine Studies in Gastric Secretion During the Night , Am. J. Digest. Dis. & Nutrition 1:778, 1935. 3. Val Dez, F. C.: The Night Secretion of Free Hydrochloric Acid in the Stomach , Illinois M. J. 81:149, 1942. 4. Sandweiss, D. J.; Sugarman, M. H.; Podolsky, H. M., and Friedman, M. H. F.: Nocturnal Gastric Secretion in Duodenal Ulcer: Studies on Normal Subjects and Patients with Their Bearing on Ulcer Management , J. A. M. A. 130:258 ( (Feb. 2) ) 1946. 5. Sandweiss, D. J.; Friedman, M. H. F.; Sugarman, M. H., and Podolsky, H. M.: Nocturnal Gastric Secretion: Studies on Normal Subjects and Patients with Duodenal Ulcer , Gastroenterology 7:38, 1946. 6. Dragstedt, L. R.: Personal communication to the authors. 7. Thornton, F. T., Jr.; Storer, E. H., and Dragstedt, L. R.: Supradiaphragmatic Section of the Vagus Nerves , J. A. M. A. 130:764 ( (March 23) ) 1946. 8. Levin, E.; Hamann, A., and Palmer, W. L.: The Effect of Radiation Therapy on the Nocturnal Gastric Secretion in Patients with Duodenal Ulcer , Proc. Central Soc. Clin. Research 19:32, 1946 9. Gastroenterology 8:565, 1947. 10. Herbert D. Landahl, assistant professor of mathematical biophysics, aided in the statistical analysis of the data. 11. Sippy, B. W.: Gastric and Duodenal Ulcer , J. A. M. A. 64:1625 ( (May 15) ) 1915. 12. Palmer, W. L.: Fundamental Difficulties in the Treatment of Peptic Ulcer , J. A. M. A. 101:1604 ( (Nov. 18) ) 1933. 13. Palmer, W. L., and Templeton, F. E.: The Effect of Radiation Therapy on Gastric Secretion , J. A. M. A. 112:1429 ( (April 15) ) 1939. 14. Dragstedt.5 Thornton, Storer and Dragstedt.6 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

NOCTURNAL GASTRIC SECRETION: Studies on Normal Subjects and on Patients with Duodenal Ulcer, Gastric Ulcer and Gastric Carcinoma

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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1948 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1948.01240010352005
Publisher site
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Abstract

Abstract THE PURPOSE of this paper is to present the results of studies on the gastric secretion of normal persons and of patients with duodenal ulcer, gastric ulcer and gastric carcinoma. Henning and Norpoth,1 Winkelstein2 and Val Dez3 observed a greater free acidity in the nocturnal secretion of patients with duodenal ulcer than in that of a normal group. Sandweiss and others,4 on the other hand, concluded that male patients with uncomplicated duodenal ulcer do not secrete larger amounts of gastric juice than normal persons during the period from midnight to 7 a.m. It is difficult to compare the results obtained by these various workers inasmuch as varying methods of study were employed. Dragstedt and his co-workers5 found that the average volume of the twelve hour continuous gastric secretion in 135 unselected patients with duodenal ulcer was 1,085 cc.; the average free acidity of the total References 1. Henning, N., and Norpoth, L.: Untersuchungen über die sekretorische Funktion des Magens während des nächtlichen Schlafes , Arch. f. Verdauungskr. 53:64, 1933.Crossref 2. Winkelstein, A.: One Hundred and Sixty-Nine Studies in Gastric Secretion During the Night , Am. J. Digest. Dis. & Nutrition 1:778, 1935. 3. Val Dez, F. C.: The Night Secretion of Free Hydrochloric Acid in the Stomach , Illinois M. J. 81:149, 1942. 4. Sandweiss, D. J.; Sugarman, M. H.; Podolsky, H. M., and Friedman, M. H. F.: Nocturnal Gastric Secretion in Duodenal Ulcer: Studies on Normal Subjects and Patients with Their Bearing on Ulcer Management , J. A. M. A. 130:258 ( (Feb. 2) ) 1946. 5. Sandweiss, D. J.; Friedman, M. H. F.; Sugarman, M. H., and Podolsky, H. M.: Nocturnal Gastric Secretion: Studies on Normal Subjects and Patients with Duodenal Ulcer , Gastroenterology 7:38, 1946. 6. Dragstedt, L. R.: Personal communication to the authors. 7. Thornton, F. T., Jr.; Storer, E. H., and Dragstedt, L. R.: Supradiaphragmatic Section of the Vagus Nerves , J. A. M. A. 130:764 ( (March 23) ) 1946. 8. Levin, E.; Hamann, A., and Palmer, W. L.: The Effect of Radiation Therapy on the Nocturnal Gastric Secretion in Patients with Duodenal Ulcer , Proc. Central Soc. Clin. Research 19:32, 1946 9. Gastroenterology 8:565, 1947. 10. Herbert D. Landahl, assistant professor of mathematical biophysics, aided in the statistical analysis of the data. 11. Sippy, B. W.: Gastric and Duodenal Ulcer , J. A. M. A. 64:1625 ( (May 15) ) 1915. 12. Palmer, W. L.: Fundamental Difficulties in the Treatment of Peptic Ulcer , J. A. M. A. 101:1604 ( (Nov. 18) ) 1933. 13. Palmer, W. L., and Templeton, F. E.: The Effect of Radiation Therapy on Gastric Secretion , J. A. M. A. 112:1429 ( (April 15) ) 1939. 14. Dragstedt.5 Thornton, Storer and Dragstedt.6

Journal

Archives of Surgery – American Medical Association

Published: Mar 1, 1948

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